Abstract
The third most malignant disease diagnosed worldwide is colorectal cancer (CRC). CRC treatment by chemo- and radiotherapy is challenging due to the cancer’s ability to activate major transcription factors such as NF-κB. Curcumin, a phytochemical, is known to downregulate NF-κB signaling in CRC cell lines and to exhibit anticarcinogenic properties. Therefore, curcumin and its analogues are novel therapeutic agents that could be used in the treatment of CRC growth and metastasis.
The original version of this chapter was revised. The book was inadvertently published without Abstracts and Keywords, which are now included in all the chapters. An erratum to this chapter can be found at https://doi.org/10.1007/978-981-10-6728-0_39
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Nagaraju, G.P., Pattnaik, S. (2017). Curcumin Suppresses Colorectal Cancer Growth and Metastasis by Inhibiting NF-κB Activity. In: Nagaraju, G., Bramhachari, P. (eds) Role of Transcription Factors in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-10-6728-0_18
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DOI: https://doi.org/10.1007/978-981-10-6728-0_18
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