Activator Protein-1 Transcription Factors in Pathological Cancers

  • Siva Krishna Prasad Konduru
  • Ganji Lakshmi Vara Prasad
  • Neha Merchant
  • Santoshi MuppalaEmail author


Activator protein-1 transcription factors play a critical role in the development of many cancers. Although many studies indicated the role of transcription factors driving the progression of cancer, there is still a knowledge gap in the process of better understanding the molecular mechanisms controlled by AP-1 transcription factors during cancer advancement. In conclusion, we have evaluated the role of transcription factors which provides new insights into mechanisms of regulation of colorectal cancer by AP-1 family transcription factors.


AP-1 transcription factors Colorectal cancer Metastasis Oncogenes 





Activator protein-1


Activating transcription factor


Colorectal cancer


Musculoaponeurotic liposarcoma




TPA-response element


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© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  • Siva Krishna Prasad Konduru
    • 1
  • Ganji Lakshmi Vara Prasad
    • 2
  • Neha Merchant
    • 3
  • Santoshi Muppala
    • 4
    Email author
  1. 1.Department of Medical ImagingSangre Grande General HospitalSangre GrandeTrinidad and Tobago
  2. 2.Dr. LV Prasad Diagnostics and Research LaboratoryHyderabadIndia
  3. 3.Department of Hematology and Medical Oncology, Winship Cancer InstituteEmory UniversityAtlantaUSA
  4. 4.Department of Molecular CardiologyCleveland ClinicClevelandUSA

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