Curcumin: Its Role in Regulation of HIF-1α in Gastric Cancer

Chapter

Abstract

Gastric cancer is a malignancy and is the fourth most common cause of cancer globally. An oxygen-deficient microenvironment is a common state of gastric cancer, associated with tumor invasion and metastasis. Under hypoxic conditions, cancer cells start their own adaptive pathways to have a facilitated oxygen and energy supply for survival. In this condition, hypoxia-inducible factors (HIF) such as HIF-1α have a vital role particularly in cellular response to hypoxia and stimulate the major hallmark processes of tumor development, for example, angiogenesis, glucose transport, and metabolism by activating the transcriptional factors of various targeted gene involved in tumor development. Curcumin, a major phytochemical extracted from roots of Curcuma longa, inhibits proliferation of many types of solid cancer cells. Earlier, curcumin shows strong therapeutic potential against gastric cancer cell lines by downregulating the levels of the oncogene c-Myc expression and thereby hindering the expression of the targeted gene. Curcumin also exhibits antitumor effects under hypoxic conditions by significantly decreasing levels of hypoxia-induced HIF-1α protein, in cancer cells. Furthermore, curcumin eliminates cell proliferation, migration, and invasiveness generated by a hypoxic microenvironment and associated with HIF-1α accumulation.

Keywords

Gastric cancer Curcumin HIF-1α 

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Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  1. 1.P.G. Department of ZoologyBerhampur UniversityBerhampurIndia

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