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Is Mitochondrial Cell Fragility a Cell Weakness?

  • William WangEmail author
  • Jiayuan Hou
  • Zhenghua Zhu
  • Hao FangEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1038)

Abstract

Mitochondrial dysfunction has historically been linked to the cessation of cell function and ageing. Downstream effects such as reduced calcium buffering capacity, elevated levels of reactive oxygen species, and alterations in adenosine-5′-triphosphate are linked to a wide variety of pathological diseases. The importance of the mitochondria has increasingly been highlighted due to its potential as a therapeutic target for drug intervention and cell elimination in cancer. In addition, due to its origin, drugs targeting bacteria are required to be thoroughly tested prior to administration to prevent toxicity for the mitochondria. In this chapter, we will discuss a variety of factors that could influence mitochondrial dysfunction and highlight potential solutions to these. A comprehensive understanding regarding the mechanisms underlying mitochondrial dysfunction could aid in developing future therapeutic targets in multiple pathologies such as cancer and liver diseases.

Keywords

Mitochondria Dysfunction Therapy Fragility Cancer 

Notes

Acknowledgements

The work was supported by Zhongshan Distinguished Professor Grant (XDW), National Nature Science Foundation of China (91230204, 81270099, 81320108001, 81270131, 81300010), Shanghai Committee of Science and Technology (12JC1402200, 12431900207, 11410708600, 14431905100), Operation funding of Shanghai Institute of Clinical Bioinformatics, Ministry of Education for Academic Special Science and Research Foundation for PhD Education (20130071110043), and National Key Research and Development Program (2016YFC0902400, 2017YFSF090207).

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Copyright information

© The Editor(s) (if applicable) and The Author(s) 2018 2017

Authors and Affiliations

  1. 1.Department of Anaesthesiology, Jinshan HospitalFudan UniversityShanghaiChina
  2. 2.Department of Anaesthesiology, Zhongshan HospitalFudan UniversityShanghaiChina
  3. 3.Zhongshan Hospital Institute of Clinical ScienceFudan UniversityShanghaiChina

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