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The Role of DNA Repair in Maintaining Mitochondrial DNA Stability

  • Linlin ZhangEmail author
  • Aurelio ReyesEmail author
  • Xiangdong WangEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1038)

Abstract

Mitochondria are vital double-membrane organelles that act as a “powerhouse” inside the cell and have essential roles to maintain cellular functions, e.g., ATP production, iron-sulfur synthesis metabolism, and steroid synthesis. An important difference with other organelles is that they contain their own mitochondrial DNA (mtDNA). Such powerful organelles are also sensitive to both endogenous and exogenous factors that can cause lesions to their structural components and their mtDNA, resulting in gene mutations and eventually leading to diseases. In this review, we will mainly focus on mammalian mitochondrial DNA repair pathways that safeguard mitochondrial DNA integrity and several important factors involved in the repair process, especially on an essential pathway, base excision repair. We eagerly anticipate to explore more methods to treat related diseases by constantly groping for these complexes and precise repair mechanisms.

Keywords

Mitochondrial DNA Lesions DNA repair BER Major pathway 

Notes

Acknowledgments

The work was supported by the Zhongshan Distinguished Professor Grant (XDW), the National Natural Science Foundation of China (91230204, 81270099, 81320108001, 81270131, 81300010), the Shanghai Committee of Science and Technology (12JC1402200, 12431900207, 11410708600, 14431905100), the operation funding of the Shanghai Institute of Clinical Bioinformatics, the Ministry of Education for Academic Special Science and Research Foundation for PhD Education (20130071110043), the National Key Research and Development Program (2016YFC0902400, 2017YFSF090207), and the Medical Research Council core funding (2015–2020).

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Copyright information

© The Editor(s) (if applicable) and The Author(s) 2018 2017

Authors and Affiliations

  1. 1.Zhongshan Hospital Institute of Clinical ScienceFudan University, Shanghai Medical CollegeShanghaiChina
  2. 2.MRC Mitochondrial Biology UnitUniversity of CambridgeCambridgeUK

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