Abstract
Mitochondrial DNA (mtDNA) plays an important role in immune responses during the evolution. The present chapter systemically describes its role on immune-related diseases and its interaction on immune responses. It is important to explore the main function and mechanisms of mtDNA in immune responses by which mtDNA regulates the signaling pathways of Toll-like receptor 9, autophagy, and STING. There are potentials to discover therapeutic targets of mtDNA in immune diseases and inflammation. It will be more exciting if the CRISPR-Cas9 method can be applied for mtDNA gene editing to cure diseases and provide a novel insight of mtDNA in immune responses as well as new therapies.
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Abbreviations
- ALI:
-
Acute lung injury
- CPB:
-
Cardiopulmonary bypass
- CRISPR-Cas9:
-
Prokaryotic type II clustered regularly interspaced short palindromic repeats-CRISPR-associated 9
- DAMPs:
-
Damage-associated molecular patterns
- HMGB1:
-
High-mobility group protein B1
- IRF7:
-
Interferon regulatory factor 7
- IRP:
-
Immune-related pancytopenia
- ISG:
-
Interferon-stimulated genes
- LC3B:
-
Microtubule-associated protein1 light chain 3B
- MAPKs:
-
Mitogen-activated protein kinases
- MELAS:
-
Stroke-like episodes
- MPT:
-
Mitochondrial permeability transition
- mtDNA:
-
Mitochondrial DNA
- MYD88:
-
Response protein 88
- NAFLD:
-
Nonalcoholic fatty liver disease
- nDNA:
-
Nuclear DNA
- NET:
-
Neutrophil extracellular traps
- NF-κB:
-
Nuclear factor-κB
- OXPHOS:
-
Oxidative phosphorylation
- PMN:
-
Polymorphonuclear neutrophils
- RA:
-
Rheumatoid arthritis
- ROS:
-
Reactive oxygen species
- SHR:
-
Spontaneously hypertensive rats
- TLR9:
-
Toll-like receptor 9
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Acknowledgments
The work was supported by Zhongshan Distinguished Professor Grant (XDW), the National Nature Science Foundation of China (91230204, 81270099, 81320108001, 81270131, 81300010), the Shanghai Committee of Science and Technology (12JC1402200, 12431900207, 11410708600, 14431905100), Operation funding of Shanghai Institute of Clinical Bioinformatics, Ministry of Education for Academic Special Science and Research Foundation for PhD Education (20130071110043), and National Key Research and Development Program (2016YFC0902400, 2017YFSF090207).
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Wang, L., Liebmen, M.N., Wang, X. (2017). Roles of Mitochondrial DNA Signaling in Immune Responses. In: Sun, H., Wang, X. (eds) Mitochondrial DNA and Diseases. Advances in Experimental Medicine and Biology, vol 1038. Springer, Singapore. https://doi.org/10.1007/978-981-10-6674-0_4
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