Metabolic Regulation in Mitochondria and Drug Resistance

  • Yue Pan
  • Min Cao
  • Jianzhou Liu
  • Qing Yang
  • Xiaoyu Miao
  • Vay Liang W. Go
  • Paul W. N. Lee
  • Gary Guishan XiaoEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1038)


Mitochondria are generally considered as a powerhouse in a cell where the majority of the cellular ATP and metabolite productions occur. Metabolic rewiring and reprogramming may be initiated and regulated by mitochondrial enzymes. The hypothesis that cellular metabolic rewiring and reprogramming processes may occur as cellular microenvironment is disturbed, resulting in alteration of cell phenotype, such as cancer cells resistant to therapeutics seems to be now acceptable. Cancer metabolic reprogramming regulated by mitochondrial enzymes is now one of the hallmarks of cancer. This chapter provides an overview of cancer metabolism and summarizes progress made in mitochondria-mediated metabolic regulation in cancer drug resistance.


Mitochondrial Metabolism Drug resistance Signaling pathway 



The work was supported by the Dalian University of Technology Distinguished Professor Grant (Gary Guishan Xiao), the National Natural Science Foundation of China (81770846, 81642006, 81272430), Agi Hirshberg international pancreatic disease center funds (H2015PC01), talent introduction funds of Dalian University of Technology (852004), and major research projects of Dalian University of Technology (DUT17ZD308).


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Copyright information

© The Editor(s) (if applicable) and The Author(s) 2018 2017

Authors and Affiliations

  • Yue Pan
    • 1
  • Min Cao
    • 1
  • Jianzhou Liu
    • 1
  • Qing Yang
    • 1
  • Xiaoyu Miao
    • 1
  • Vay Liang W. Go
    • 2
  • Paul W. N. Lee
    • 3
  • Gary Guishan Xiao
    • 1
    • 2
    • 3
    • 4
    Email author
  1. 1.School of Pharmaceutical Science and TechnologyDalian University of TechnologyDalianChina
  2. 2.Agi Hirshberg UCLA Center for Pancreas Diseases, University of CaliforniaLos AngelesUSA
  3. 3.Harbor University of California Los Angeles Medical CenterTorranceUSA
  4. 4.Functional Genomics and Proteomics LaboratoriesCreighton University Medical CenterOmahaUSA

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