Skip to main content
SpringerLink
Log in

How Far Can Mitochondrial DNA Drive the Disease?

  • Chapter
  • First Online:
Mitochondrial DNA and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1038))

Abstract

Mitochondria are one of the dominant drivers for producing cellular energy to meet a large number of biological functions, of which the mitochondrial DNA (mtDNA) is the control center of energetic driving force and the dominant driver of mitochondrial molecular diversification. mtDNA transcription generates the necessary RNAs to regulate the extent and nature of mtRNA post-transcriptional modifications and the activity of nucleus-encoded enzymes. With a special focus on mtDNA, the current volume aims to overview the biology and structures of mtDNA, regulatory roles of mtDNA in lung diseases, or involvement of mtDNA in metabolism. We explore the significance of mtDNA sequencing, methylation, stability, and mutation in the pathogenesis of the diseases. Molecular mechanisms by which mtDNA contribute to the regulation of mitochondrial homeostasis and drug resistance are also discussed. We also point out the importance of mitochondrial ribosome, single cell biology, and gene editing in the understanding of the development of mitochondrial dysfunction in lung disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Xu MM, Pu Y, Han D, Shi Y, Cao X, Liang H, et al. Dendritic cells but not macrophages sense tumor mitochondrial DNA for cross-priming through signal regulatory protein α signaling. Immunity. 2017;47(2):363–73. https://doi.org/10.1016/j.immuni.2017.07.016. PMID: 28801234

    Article  CAS  PubMed  Google Scholar 

  2. Gao S, Tian X, Chang H, Sun Y, Wu Z, Cheng Z, et al. Two novel lncRNAs discovered in human mitochondrial DNA using PacBio full-length transcriptome data. Mitochondrion. 2017. https://doi.org/10.1016/j.mito.2017.08.002. PMID: 28802668

  3. Pearce SF, Rebelo-Guiomar P, D’Souza AR, Powell CA, Van Haute L, Minczuk M. Regulation of mammalian mitochondrial gene expression: recent advances. Trends Biochem Sci. 2017;42(8):625–39. PMID: 28285835

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Fang XC, Wang XD, Danderson M, Bai CX. Chronic obstructive pulmonary disease in China: the burden and the importance of proper management. Chest. 2011;139(4):920–9. PMID: 21467059

    Article  PubMed  Google Scholar 

  5. Chen C, Shi L, Li Y, Wang X, Yang S. Disease-specific dynamic biomarkers selected by integrating inflammatory mediators with clinical informatics in ARDS patients with severe pneumonia. Cell Biol Toxicol. 2016;32(3):169–84. PMID: 27095254

    Article  PubMed  PubMed Central  Google Scholar 

  6. Shi L, Zhu B, Xu M, Wang X. Selection of AECOPD-specific immunomodulatory biomarkers by integrating genomics and proteomics with clinical informatics. Cell Biol Toxicol. 2017. https://doi.org/10.1007/s10565-017-9405-x. PMID: 28779230

  7. Liu F, Sanin DE, Wang X. Mitochondrial DNA in lung cancer. Adv Exp Med Biol. 2017;1038:2

    Google Scholar 

  8. Wang X. New biomarkers and therapeutics can be discovered during COPD-lung cancer transition. Cell Biol Toxicol. 2016;32(5):359–61. PMID: 27405768

    Article  PubMed  Google Scholar 

  9. Gu J, Wang X. New future of cell biology and toxicology: thinking deeper. Cell Biol Toxicol. 2016;32(1):1–3. PMID: 26874518

    Article  PubMed  Google Scholar 

  10. Wang X. CBT profiles of cabozantinib approved for advanced renal cell carcinomas. Cell Biol Toxicol. 2016;32:259–61. PMID:27383755

    Article  CAS  PubMed  Google Scholar 

  11. Qian M, Spada C, Wang X. Approach, application and bioethics of mtDNA sequencing in cancer. Adv Exp Med Biol. 2017;1038:3

    Google Scholar 

  12. Matilainen O, Quirós PM, Auwerx J. Mitochondria and epigenetics – crosstalk in homeostasis and stress. Trends Cell Biol. 2017;27(6):453–63. PMID: 28274652

    Article  CAS  PubMed  Google Scholar 

  13. Wang L, Liebmen M, Wang X. Roles of mitochondrial DNA signaling in immune responses. Adv Exp Med Biol. 2017;1038:4

    Google Scholar 

  14. Hou J, Eldeeb MA, Wang X. Beyond deubiquitylation: USP30-mediated regulation of mitochondrial homeostasis. Adv Exp Med Biol. 2017;1038:5

    Google Scholar 

  15. Lv J, Bhatia M, Wang X. Roles of mitochondrial DNA in energy metabolism. Adv Exp Med Biol. 2017;1038:6

    Google Scholar 

  16. Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, et al. DNA-PK promotes the mitochondrial, metabolic, and physical decline that occurs during aging. Cell Metab. 2017;25(5):1135–1146.e7. PMID: 28467930

    Article  CAS  PubMed  Google Scholar 

  17. Kikuchi S, Ninomiya T, Kohno T, Kojima T, Tatsumi H. Cobalt inhibits motility of axonal mitochondria and induces axonal degeneration in cultured dorsal root ganglion cells of rat. Cell Biol Toxicol. 2017. https://doi.org/10.1007/s10565-017-9402-0. PMID: 28656345

  18. Zerin T, Kim JS, Gil HW, Song HY, Hong SY. Effects of formaldehyde on mitochondrial dysfunction and apoptosis in SK-N-SH neuroblastoma cells. Cell Biol Toxicol. 2015;31(6):261–72. PMID: 26728267

    Article  CAS  PubMed  Google Scholar 

  19. Vedi M, Sabina EP. Assessment of hepatoprotective and nephroprotective potential of withaferin a on bromobenzene-induced injury in Swiss albino mice: possible involvement of mitochondrial dysfunction and inflammation. Cell Biol Toxicol. 2016;32(5):373–90. PMID: 27250656

    Article  CAS  PubMed  Google Scholar 

  20. Song D, Cretoiu D, Wang X. Mitochondrial DNA in telocytes. Adv Exp Med Biol. 2017;1038:7

    Google Scholar 

  21. Pan Y, Cao M, Yang Q, Go VG, Lee PWN, Xiao GG. Metabolic regulation in mitochondria and drug resistance. Adv Exp Med Biol. 2017;1038:8

    Google Scholar 

  22. Lu B. Mitochondrial Lon protease and cancer. Adv Exp Med Biol. 2017;1038:9

    Google Scholar 

  23. Guney Eskiler G, Cecener G, Tunca B, Egeli U. An in vitro model for the development of acquired tamoxifen resistance. Cell Biol Toxicol. 2016;32(6):563–81. PMID: 27585693

    Article  CAS  PubMed  Google Scholar 

  24. Peng WX, Han X, Zhang CL, Ge L, FY D, Jin J, Gong AH. FoxM1-mediated RFC5 expression promotes temozolomide resistance. Cell Biol Toxicol. 2017. https://doi.org/10.1007/s10565-017-9381-1. PMID: 28185110

  25. Gu W, Dong N, Wang P, Shi C, Yang J, Wang J. Tamoxifen resistance and metastasis of human breast cancer cells were mediated by the membrane-associated estrogen receptor ER-α36 signaling in vitro. Cell Biol Toxicol. 2017;33(2):183–95. PMID: 27837347

    Article  CAS  PubMed  Google Scholar 

  26. Sidor-Kaczmarek J, Cichorek M, Spodnik JH, Wójcik S, Moryś J. Proteasome inhibitors against amelanotic melanoma. Cell Biol Toxicol. 2017. https://doi.org/10.1007/s10565-017-9390-0. PMID: 28281027

  27. Ge S, Li T, Yao Q, Yan H, Huiyun Z, Zheng Y, Zhang B, He S. Expression of proteinase-activated receptor (PAR)-2 in monocytes from allergic patients and potential molecular mechanism. Cell Biol Toxicol. 2016;32(6):529–42. PMID: 27423452

    Article  CAS  PubMed  Google Scholar 

  28. Zhang L, Reyes A, Wang X. The role of base excision repair in maintaining mitochondrial DNA stability. Adv Exp Med Biol. 2017;1038:10

    Google Scholar 

  29. Zhang L, Wang W, Zhu B, Wang X. Regulatory roles of mitochondrial ribosome in lung diseases and single cell biology. Adv Exp Med Biol. 2017;1038:11

    Google Scholar 

  30. Zhang L, Wang W, Zhu B, Wang X. Epithelial mitochondrial dysfunction in lung disease. Adv Exp Med Biol. 2017; 1038: 12

    Google Scholar 

  31. Gao D, Zhu B, Sun H, Wang X. Mitochondrial DNA methylation and related disease. Adv Exp Med Biol. 2017;1038:13

    Google Scholar 

  32. Chu MP, Kriangkum J, Venner CP, Sandhu I, Hewitt J, Belch AR, Pilarski LM. Addressing heterogeneity of individual blood cancers: the need for single cell analysis. Cell Biol Toxicol. 2017;33(2):83–97. PMID: 27761761

    Article  CAS  PubMed  Google Scholar 

  33. Wang W, Gao D, Wang X. Can single-cell RNA sequencing crack the mystery of cells? Cell Biol Toxicol. 2017. https://doi.org/10.1007/s10565-017-9404-y. PMID: 28733864

  34. Wang W, Zhu B, Wang X. Dynamic phenotypes: illustrating a single-cell odyssey. Cell Biol Toxicol. 2017.; PMID: 28638956

    Google Scholar 

  35. Wang W, Wang X. Single-cell CRISPR screening in drug resistance. Cell Biol Toxicol. 2017;33(3):207–10. https://doi.org/10.1007/s10565-017-9396-7. PMID: 28474250

    Article  CAS  PubMed  Google Scholar 

  36. Wang W, Hou J, Zhu Z, Fang H. Is mitochondrial cell fragility a cell weakness? Adv Exp Med Biol. 2017;1038:14

    Google Scholar 

Download references

Acknowledgments

The work was supported by Zhongshan Distinguished Professor Grant (XDW), the National Nature Science Foundation of China (91230204, 81270099, 81320108001, 81270131, 81300010), the Shanghai Committee of Science and Technology (12JC1402200, 12431900207, 11410708600, 14431905100), Operation funding of Shanghai Institute of Clinical Bioinformatics, Ministry of Education for Academic Special Science and Research Foundation for PhD Education (20130071110043), and National Key Research and Development Program (2016YFC0902400, 2017YFSF090207).

Author information

Authors and Affiliations

  1. Liaoning Province Key Laboratory of Cancer Metabolomics, Jinzhou Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China

    Hongzhi Sun

  2. Medical Examination Center of Zhongshan Hospital, Fudan University, Shanghai, China

    Weibin Shi

  3. Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Medical College, Shanghai, China

    Xiangdong Wang

Authors
  1. Hongzhi Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Weibin Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiangdong Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Hongzhi Sun , Weibin Shi or Xiangdong Wang .

Editor information

Editors and Affiliations

  1. Liaoning Province Key Laboratory of Cancer Metabolomics, Jinzhou Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China

    Hongzhi Sun

  2. Zhongshan Hospital Institute of Clinical Science, Fudan University, Shanghai Medical College, Shanghai, China

    Xiangdong Wang

Rights and permissions

Reprints and permissions

Copyright information

© 2017 The Editor(s) (if applicable) and The Author(s) 2018

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Sun, H., Shi, W., Wang, X. (2017). How Far Can Mitochondrial DNA Drive the Disease?. In: Sun, H., Wang, X. (eds) Mitochondrial DNA and Diseases. Advances in Experimental Medicine and Biology, vol 1038. Springer, Singapore. https://doi.org/10.1007/978-981-10-6674-0_1

Download citation

Publish with us

Policies and ethics

Search

Navigation