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Intraoperative Radiotherapy

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Basics of Planning and Management of Patients during Radiation Therapy

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Abstract

Intraoperative irradiation therapy (IORT) refers to the delivery of irradiation at the time of an operation. This can involve the use of electrons (IOERT), high-dose-rate brachytherapy (HDR-IORT) or orthovoltage during or immediately after surgical exploration and resection with or without external beam irradiation therapy (EBRT) and chemotherapy. IORT tries to achieve higher effective doses of irradiation when dose-limiting structures are surgically displaced away from the tumour bed. If both electrons (IOERT) and brachytherapy are feasible, electrons are chosen because of shorter set-up and treatment times, better depth dose and more homogeneous dose distribution. Most abdominal sites are usually easily treated with IOERT approaches using either flat or 15° bevel applicators. The biologic effectiveness of single-dose IORT is considered equivalent to 1.5–2.5 times the same total dose of fractionated EBRT.

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Authors and Affiliations

  1. Department of Radiotherapy, Regional Cancer Centre, JIPMER Department of Radiotherapy, Puducherry, India

    Ashutosh Mukherji

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  1. Ashutosh Mukherji
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Mukherji, A. (2018). Intraoperative Radiotherapy. In: Basics of Planning and Management of Patients during Radiation Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-10-6659-7_17

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  • DOI: https://doi.org/10.1007/978-981-10-6659-7_17

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-6658-0

  • Online ISBN: 978-981-10-6659-7

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