Abstract
Maturity onset diabetes of the young (MODY), a monogenic form of diabetes is caused by mutation in a single gene. This is caused due to the improper functioning of beta cells present in the pancreas. MODY accounts for about 1–5% of all cases of diabetes. In this paper gene mapping, sequence analysis, phylogenetics, protein network design and pathway analysis of eleven subtypes of MODY is done. The molecular interactions of three prevalent types of MODY genes HNF4A, GCK and HNF1A are analyzed. This study has used latest tools of bioinformatics such as VarioWatch, MUSCLE, Jalview, Phylogeny.fr, STRING, KEGG Pathway and Mechismo to perform comprehensive analysis of MODY proteins.
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Nihitha, Y., Lavanya Devi, G., Vani, V.J. (2018). A Study on Proteins Associated with MODY Using Computational Biology. In: Cognitive Science and Health Bioinformatics. SpringerBriefs in Applied Sciences and Technology(). Springer, Singapore. https://doi.org/10.1007/978-981-10-6653-5_3
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DOI: https://doi.org/10.1007/978-981-10-6653-5_3
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