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DJ-1/PARK7 Protein pp 1–4Cite as

Introduction/Overview

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1037))

Abstract

The DJ-1 gene is an oncogene and also causative gene for a familial form of Parkinson disease. Although exits of cancer and neurodegenerative diseases, including Parkinson disease, are completely opposite, there are some common points of view between both diseases, including growth and death signaling pathways, and oxidative stresses affect the onset and pathogenesis of both cancer and neurodegenerative diseases. DJ-1 has versatile functions and plays a role in protection against oxidative stress. Inactivation and/or excess activation of DJ-1 functions, therefore, leads to onsets of oxidative stress-related diseases such as type 2 diabetes and male infertility in addition to cancer and neurodegenerative diseases, and studies about DJ-1 will give rise to the common mechanism among these diseases. Furthermore, secreted DJ-1 levels in serum and DJ-1-binding compounds will be a diagnostic biomarker and therapeutic drug for neurodegenerative diseases, respectively.

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Author information

Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan

    Hiroyoshi Ariga

  2. Faculty of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita-ku, Sapporo, 060-8589, Japan

    Sanae M. M. Iguchi-Ariga

Authors
  1. Hiroyoshi Ariga
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  2. Sanae M. M. Iguchi-Ariga
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Correspondence to Hiroyoshi Ariga .

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Editors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

    Hiroyoshi Ariga

  2. Faculty of Agriculture, Hokkaido University, Sapporo, Japan

    Sanae M. M. Iguchi-Ariga

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© 2017 Springer Nature Singapore Pte Ltd.

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Ariga, H., Iguchi-Ariga, S.M.M. (2017). Introduction/Overview. In: Ariga, H., Iguchi-Ariga, S. (eds) DJ-1/PARK7 Protein. Advances in Experimental Medicine and Biology, vol 1037. Springer, Singapore. https://doi.org/10.1007/978-981-10-6583-5_1

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