Clinical, Biological, and Therapeutic Characteristics Between Depression with and Without Medical Illness
Comorbid medical illness with depression is quite a challenge to the successful treatment for both clinician and patient. First, chronic medical illness can make clinician confused to recognize and treat depression, by overlapped symptoms. Second, individuals having both depression and medical illness respond poorer with lower recovery rates, more impaired function, and higher relapse of depressive episodes than individuals with only depression. This poor therapeutic response often comes from poor adherence, comorbid somatic symptoms, and pain as stress which is hidden in other comorbidities. Decreased quality of life and increased costs accompany to this burdensome. Careful evaluation with MDD and comorbid medical illness followed by appropriate collaborative care can lead individuals to better prognosis in the future.
KeywordsComorbidity Medical illness Endocrine Immune Pain
- Kantorova E, et al. Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue. Neurol Res. 2017:1–8.Google Scholar
- Orgeta V, Qazi A, Spector AE, Orrell M. Psychological treatments for depression and anxiety in dementia and mild cognitive impairment. Cochrane Database Syst Rev. 2014:CD009125.Google Scholar
- Qaseem A, Barry MJ, Kansagara D, Clinical Guidelines Committee of the American College of P. Nonpharmacologic versus pharmacologic treatment of adult patients with major depressive disorder: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2016;164:350–9.CrossRefGoogle Scholar
- Woltmann E, Grogan-Kaylor A, Perron B, Georges H, Kilbourne AM, Bauer MS. Comparative effectiveness of collaborative chronic care models for mental health conditions across primary, specialty, and behavioral health care settings: systematic review and meta-analysis. Am J Psychiatry. 2012;169:790–804.CrossRefGoogle Scholar