Clinical, Biological, and Therapeutic Characteristics Between Depression with and Without Medical Illness

  • Kiwon Kim
  • Hong Jin Jeon


Comorbid medical illness with depression is quite a challenge to the successful treatment for both clinician and patient. First, chronic medical illness can make clinician confused to recognize and treat depression, by overlapped symptoms. Second, individuals having both depression and medical illness respond poorer with lower recovery rates, more impaired function, and higher relapse of depressive episodes than individuals with only depression. This poor therapeutic response often comes from poor adherence, comorbid somatic symptoms, and pain as stress which is hidden in other comorbidities. Decreased quality of life and increased costs accompany to this burdensome. Careful evaluation with MDD and comorbid medical illness followed by appropriate collaborative care can lead individuals to better prognosis in the future.


Comorbidity Medical illness Endocrine Immune Pain 


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of NeuropsychiatrySeoul National University Bundang HospitalSeongnamSouth Korea
  2. 2.Department of Psychiatry, Depression Center, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea

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