Cognitive Dimensions of Depression: Assessment, Neurobiology, and Treatment
Cognitive impairment in patients with depression has great clinical relevance, as depressed patients with cognitive impairment have more physical diseases, greater reduced social functionality, and, eventually, higher mortality. Although cognitive decline may simply be a symptom of depression, accurate assessment and treatment of cognitive impairment is crucial, as it is considered a key risk factor for the prognosis of possible neurocognitive disorders, such as Alzheimer’s disease. In this review, we investigated psychological and biological mechanisms of cognitive impairment in patients with depression and briefly discuss the methods to assess neurocognitive function in depression. Furthermore, we presented some issues about which to be cautious in the therapeutic setting.
KeywordsCognition Cognitive impairment Neurocognitive function Amyloid positron emission tomography
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