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Microwave Chemistry in Liquid Media

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Microwave Chemical and Materials Processing

Abstract

This chapter summarizes the features and caveats in microwave-assisted chemistry. Since many samples of chemical reactions are liquids, the handling of liquid samples in microwave heating is illustrated. Also noted are problems such as accidents, temperature distribution, heat insulation, and impurities. The chapter also introduces a method of microwave chemical synthesis while cooling. Finally, it reports on existing commercial bench-scale microwave chemical synthesis equipment and scaled-up equipment. The coffee break introduces a unique hybrid cooking system.

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References

  1. S. Horikoshi, N. Serpone, Chapter 3, in Microwaves in nanoparticle synthesis: fundamentals and applications, ed. by S. Horikoshi, N. Serpone (Wiley-VCH Verlag GmbH, Weinheim, Germany, 2013)

    Chapter  Google Scholar 

  2. http://www.jeh-center.org/mw_de.html

  3. J.-S. Schanche, Microwave synthesis solutions from personal chemistry. Mol. Divers. 7, 293–300 (2003)

    Article  CAS  Google Scholar 

  4. M.A. Herrero, J.M. Kremsner, C.O. Kappe, Nonthermal microwave effects revisited: on the importance of internal temperature monitoring and agitation in microwave chemistry. J. Org. Chem. 73, 36–47 (2008)

    Article  CAS  Google Scholar 

  5. T. Sumi, R. Dillert, S. Horikoshi, A novel microwave thermodynamic model for alcohol with clustering structure in non-polar solution. J. Phys. Chem. B 119, 14479–14485 (2015)

    Article  CAS  Google Scholar 

  6. S. Horikoshi, M. Kamata, N. Serpone, Energy savings through microwave selective heating of Pd/AC catalyst particulates in a fixed-bed reactor using a vacuum-filled Dewar-like double-walled microwave continuous flow reactor. Chem. Eng. Technol. 39, 1575–1577 (2016)

    Article  CAS  Google Scholar 

  7. S. Horikoshi, A. Osawa, Y. Suttisawat, M. Abe, N. Serpone, A novel Dewar-like reactor for maintaining constant heat and enhancing product yields during microwave-assisted organic syntheses. Org. Process Res. Dev. 14, 1453–1456 (2010)

    Article  CAS  Google Scholar 

  8. http://web.mit.edu/16.unified/www/FALL/thermodynamics/notes/node123.html

  9. T.L. Bergman, A.S. Lavine, F.P. Incropera, D.P. DeWitt in Introduction to Heat Transfer, 6th edn. (Wiley–VCH Verlag, Weinheim, USA, 2011)

    Google Scholar 

  10. S. Horikoshi, M. Kamata, N. Serpone, Energy savings through microwave selective heating of Pd/AC catalyst particulates in a fixed-bed reactor using a vacuum-filled Dewar-like double-walled microwave continuous flow reactor. Chem. Eng. Technol. 39, 1575–1577 (2016)

    Article  CAS  Google Scholar 

  11. H.M. Kingston, S.J. Haswell, Microwave enhanced chemistry (American Chemical Society, Washington DC, USA, 1997), p. 12

    Google Scholar 

  12. D. Stuerga, M. Delmotte, in Microwaves in Organic Synthesis, 2nd edn. ed. by A. Loupy (Wiley–VCH Verlag, Weinheim, Germany, 2006) Chapter 1, p. 27

    Google Scholar 

  13. S. Horikoshi, N. Serpone, in Microwaves in Organic Synthesis, 3rd edn. eds. A. de la Hoz, A. Loupy (Wiley-VCH Verlag GmbH, Weinheim, Germany, 2012)

    Google Scholar 

  14. S. Horikoshi, T. Sumi, N. Serpone, Unusual effect of the magnetic field component of the microwave radiation on aqueous electrolyte solutions. J. Microw. Power Electromagn. Energy 46, 215–228 (2012)

    Article  Google Scholar 

  15. S. Horikoshi, T. Sumi, N. Serpone, Unusual effect of the magnetic field component of the microwave radiation on aqueous electrolyte solutions. J. Microw. Power Electromagn. Energy 46, 215–228 (2012)

    Article  Google Scholar 

  16. K.D. Raner, C.R. Strauss, R.W. Trainor, A new microwave reactor for batch-wise organic synthesis. J. Org. Chem. 60, 2456–2460 (1995)

    Article  CAS  Google Scholar 

  17. B.K. Singh, P. Appukkuttan, S. Claerhout, V.S. Parmar, E. V. d. Eycken, Copper(II)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling. Org. Lett. 8, 1863–1866 (2006)

    Article  CAS  Google Scholar 

  18. J. Kurfürstova, M. Hájek, Microwave-induced catalytic transformation of 2-tert-butylphenol at low temperatures. Res. Chem. Intermed. 30, 673–681 (2004)

    Article  Google Scholar 

  19. R.K. Arvela, N.E. Leadbeater, Suzuki coupling of aryl chlorides with phenylboronic acid in water, using microwave heating with simultaneous cooling. Org. Lett. 7, 2101–2104 (2005)

    Article  CAS  Google Scholar 

  20. S. Horikoshi, N. Ohmori, M. Kajitani, N. Serpone, Microwave-enhanced bromination of a terminal alkyne in short time at ambient temperature: Synthesis of phenylacetylene bromide. J. Photochem. Photobiol. A Chem. 189, 374–379 (2007)

    Article  CAS  Google Scholar 

  21. N.E. Leadbeater, S.J. Pillsbury, E. Shanahan, V.A. Williams, An assessment of the technique of simultaneous cooling in conjunction with microwave heating for organic synthesis. Tetrahedron 61, 3565–3585 (2005)

    Article  CAS  Google Scholar 

  22. S. Horikoshi, M. Kajitani, N. Serpone, The microwave-/photo-assisted degradation of bisphenol-A in aqueous TiO2 dispersions revisited Re-assessment of the microwave non-thermal effect. J. Photochem. Photobiol. A Chem. 188, 1–4 (2007)

    Article  CAS  Google Scholar 

  23. M. Lamberto, D.F. Corbettb, J.D. Kilburna, Microwave assisted free radical cyclisation of alkenyl and alkynyl isocyanides with thiols. Tetrahedron Lett. 44, 1347–1349 (2003)

    Article  CAS  Google Scholar 

  24. C. Wetter, A. Studer, Microwave-assisted free radical chemistry using the persistent radical effect, Chem. Commun. 174–175 (2004)

    Google Scholar 

  25. C. Ericsson, L. Engman, Microwave-Assisted Group-transfer cyclization of organotellurium compounds. J. Org. Chem. 69, 5143–5146 (2004)

    Article  CAS  Google Scholar 

  26. C. Holtze, K. Tauer, Surviving radicals: promises of a microwave effect on miniemulsion polymerization for technical processes. Macromol. Rapid Commun. 28, 428–436 (2007)

    Article  CAS  Google Scholar 

  27. S. Horikoshi, J. Tsuzuki, M. Kajitani, M. Abe, N. Serpone, Microwave-enhanced radical reactions at ambient temperature. 3. Highly selective radical synthesis of 3-cyclohexyl-1-phenyl-1-butanone in a microwave double cylindrical cooled reactor. New J. Chem. 32, 2257–2262 (2008)

    Article  CAS  Google Scholar 

  28. A. Loupy, L. Perreux, M. Liagre, K. Burle, M. Moneuse, Reactivity and selectivity under microwaves in organic chemistry. Relation with medium effects and reaction mechanisms. Pure Appl. Chem. 73, 161–166 (2001)

    Article  CAS  Google Scholar 

  29. C.O. Kappe, A. Stadler, Microwaves in Organic and Medicinal Chemistry (Wiley-VCH, Weinhiem, 2005), pp. 9–28

    Book  Google Scholar 

  30. S. Horikoshi, N. Shinohara, H. Takizawa, J. Fukushima, Microwave Chemistry (Sankyo Publishing Co. Ltd., 2013)

    Google Scholar 

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Correspondence to Satoshi Horikoshi .

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Horikoshi, S., Schiffmann, R.F., Fukushima, J., Serpone, N. (2018). Microwave Chemistry in Liquid Media. In: Microwave Chemical and Materials Processing. Springer, Singapore. https://doi.org/10.1007/978-981-10-6466-1_7

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