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Membrane Lipid-Protein Interactions

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The Biophysics of Cell Membranes

Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 19))

Abstract

In this review we describe how the properties of cellular membranes govern protein structure and activity. Lipids can modulate protein functional states through general bilayer properties, or by specific binding and acting as allosteric regulators. Hydrophobic matching by solvation of the protein surface entails short-range interactions of the lipids, and cellular water affects bilayer structure through hydrating the lipid polar head groups and protein hydrophilic domains. Biomembranes have important analogies to supercritical fluids leading to raft-like nanostructures with cholesterol. Additional long-range interactions of the lipids and proteins involve the curvature stress field, where a flexible surface model (FSM) describes how collective properties of the lipids affect the conformational energetics of membrane proteins. Curvature elasticity and hydrophobicity of native lipid mixtures play key roles in functional proteolipid couplings and give insights into protein activation mechanisms in cellular membranes.

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Acknowledgments

We thank B. Kobilka, G. Lindblom, K. Palczewski, A. Parsegian, T. Huber, G. Voth, and H. Wennerström for discussions. Thanks are due to J. Kinnun for assisting with the figures, and to past and present members of our research group for contributing to this work. Research from our laboratory is supported by the U.S. National Institutes of Health.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA

    Michael F. Brown, Udeep Chawla & Suchithranga M. D. C. Perera

  2. Department of Physics, University of Arizona, Tucson, AZ, 85721, USA

    Michael F. Brown

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  1. Michael F. Brown
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  2. Udeep Chawla
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Correspondence to Michael F. Brown .

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Editors and Affiliations

  1. Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

    Richard M. Epand

  2. Sciences Faculty, Université Libre de Bruxelles, Bruxelles, Belgium

    Jean-Marie Ruysschaert

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Brown, M.F., Chawla, U., Perera, S.M.D.C. (2017). Membrane Lipid-Protein Interactions. In: Epand, R., Ruysschaert, JM. (eds) The Biophysics of Cell Membranes. Springer Series in Biophysics, vol 19. Springer, Singapore. https://doi.org/10.1007/978-981-10-6244-5_3

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