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Pseudomonas aeruginosa and Its Arsenal of Proteases: Weapons to Battle the Host

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Pathophysiological Aspects of Proteases

Abstract

Pseudomonas aeruginosa is a ubiquitous and opportunistic human pathogen that represents a critical problem to the clinician due to the increased number of resistant strains isolated from hospital settings. In addition, there is a great variety of pathologies associated with this versatile Gram-negative bacterium. P. aeruginosa cells are able to produce an incredible arsenal of virulence factors, especially secreted molecules that act singly or together to ensure the establishment, maintenance, and persistence of a successful infection in susceptible hosts. In this context, pseudomonal proteases’ roles are highlighted due to their ability to cleave key host proteinaceous substrates as well as to modulate several biological processes, for example, escaping and modulating the host immune responses in the bacterial own favor. Proteases secreted by P. aeruginosa include elastase A (LasA), elastase B (LasB), alkaline protease (AP), protease IV (PIV), Pseudomonas small protease (PASP), large protease A (LepA), MucD, and P. aeruginosa aminopeptidase (PAAP). In the present review, we discuss the role of each of these relevant proteases produced by P. aeruginosa taking into consideration their main biological functions in the bacterium–host interaction that favors the establishment of the infectious process.

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Acknowledgements

This study was supported by grants from the following Brazilian Agencies: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Fundação de Amparo à Pesquisa no Estado do Rio de Janeiro (FAPERJ).

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Authors and Affiliations

  1. Programa de Pós-Graduação em Bioquímica (PPGBq), Instituto de Química (IQ), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil

    Anna Clara M. Galdino & André L. S. Santos

  2. Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes (IMPG), Centro de Ciências da Saúde (CCS), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Anna Clara M. Galdino, Marta H. Branquinha, André L. S. Santos & Lívia Viganor

  3. The Centre for Biomimetic & Therapeutic Research, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Dublin, Ireland

    Lívia Viganor

Authors
  1. Anna Clara M. Galdino
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  2. Marta H. Branquinha
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  3. André L. S. Santos
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  4. Lívia Viganor
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Correspondence to André L. S. Santos or Lívia Viganor .

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  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Sciences, University of Manitoba, Manitoba, Canada

    Naranjan S. Dhalla

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Galdino, A.C.M., Branquinha, M.H., Santos, A.L.S., Viganor, L. (2017). Pseudomonas aeruginosa and Its Arsenal of Proteases: Weapons to Battle the Host. In: Chakraborti, S., Dhalla, N. (eds) Pathophysiological Aspects of Proteases. Springer, Singapore. https://doi.org/10.1007/978-981-10-6141-7_16

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