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Polymer Gels pp 127–140Cite as

Silica-Based Polymeric Gels as Platforms for Delivery of Phosphonate Pharmaceutics

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Part of the book series: Gels Horizons: From Science to Smart Materials ((GHFSSM))

Abstract

This chapter focuses on polymeric gel drug delivery systems used for initial immobilization and subsequent controlled release of active pharmaceutical ingredients. The primary focus is on phosphonate-based drugs, which are extensively used for a variety of medicinal applications and pathological conditions. Their most recognizable use is for osteoporosis drugs with the common names: medronate, chlodronate, etidronate, alendronate, zoledronate, obadronate, ibandronate, neridronate, etc. Herein, we present a concise literature overview of this research field, presenting research results on immobilization of phosphonates onto silica-based polymeric gels, with the goal to achieve controlled release of these ingredients into biological fluids.

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Acknowledgements

K. E. Papathanasiou thanks the Onassis Foundation for a doctoral scholarship. K. D. Demadis thanks the EU for funding the Research Program SILICAMPS-153, under the ERA.NET-RUS Pilot Joint Call for Collaborative S&T projects.

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Authors and Affiliations

  1. Crystal Engineering, Growth and Design Laboratory, Department of Chemistry, University of Crete, Voutes Campus, 71003, Heraklion, Crete, Greece

    Konstantinos E. Papathanasiou, Maria Vassaki, Argyro Spinthaki, Argyri Moschona & Konstantinos D. Demadis

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  1. Konstantinos E. Papathanasiou
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  2. Maria Vassaki
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  3. Argyro Spinthaki
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Correspondence to Konstantinos D. Demadis .

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  1. Faculty in Manufacturing, Enhanced Composites and Structures Centre, School of Aerospace, Transport and Manufacturing, Cranfield University, Cranfield, United Kingdom

    Vijay Kumar Thakur

  2. Division of Chemistry, Government Degree College Bhoranj, Himachal Pradesh University, Shimla, Himachal Pradesh, India

    Manju Kumari Thakur

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Papathanasiou, K.E., Vassaki, M., Spinthaki, A., Moschona, A., Demadis, K.D. (2018). Silica-Based Polymeric Gels as Platforms for Delivery of Phosphonate Pharmaceutics. In: Thakur, V., Thakur, M. (eds) Polymer Gels. Gels Horizons: From Science to Smart Materials. Springer, Singapore. https://doi.org/10.1007/978-981-10-6083-0_5

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