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Targeting Stemness: Implications for Precision Medicine in Breast Cancer

  • Zhi-Mei Liang
  • Yang Chen
  • Man-Li Luo
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1026)

Abstract

The genomic landscape of breast cancer has been delineated in recent years. Advances in molecular characterization and targeting strategies are making it feasible to integrate clinical, genome-based and phenotype-based diagnostic and therapeutic methods and apply them to individual patient in the era of precision medicine. Cancer stem cells (CSCs) are a subpopulation in the tumor which have the capability of self-renewal and differentiation. Breast CSCs have important clinical implications as they account for tumor initiation, maintenance, metastasis, therapy resistance, and relapse. In this chapter, we will introduce approaches used to characterize breast CSCs, crucial pathways involved in regulating cancer stemness, and implications of breast CSCs in the precision diagnosis and treatment of breast cancer. We will also discuss novel compounds and therapeutic strategies that selectively target breast CSCs. Integration of breast CSC-related molecular diagnosis and targeted therapy into the clinical workflow of precision medicine has the potential to deliver more effective treatment to breast cancer patients.

Keywords

Breast cancer Cancer stem cell Precision medicine 

Notes

Acknowledgments

We would like to thank the support from the Natural Science Foundation of China (81572890 to Luo ML), Guangdong Science and Technology Department (2015B050501004), Grant [2013] 163 from Key Laboratory of Malignant Tumor Molecular Mechanism and Translational Medicine of Guangzhou Bureau of Science and Information Technology, and Grant KLB09001 from the Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Zhi-Mei Liang
    • 1
  • Yang Chen
    • 2
  • Man-Li Luo
    • 1
  1. 1.Medical Research Center, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina
  2. 2.Department of Laboratory, Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina

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