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Regulation of Inflammatory Signaling in Health and Disease pp 63–90Cite as

Emerging Roles for Epigenetic Programming in the Control of Inflammatory Signaling Integration in Heath and Disease

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1024))

Abstract

Macrophages and dendritic cells initiate the innate immune response to infection and injury and contribute to inflammatory signaling to maintain the homeostasis of various tissues, which includes resident macrophages for the elimination of invading microorganisms and tissue damage. Inappropriate inflammatory signaling can lead to persistent inflammation and further develop into autoimmune and inflammation-associated diseases. Inflammatory signaling pathways have been well characterized, but how these signaling pathways are converted into sustained and diverse patterns of expression of cytokines, chemokines, and other genes in response to environmental challenges is unclear. Emerging evidence suggests the important role of epigenetic mechanisms in finely tuning the outcome of the host innate immune response. An understanding of epigenetic regulation of innate immune cell identity and function will enable the identification of the mechanism between gene-specific host defenses and inflammatory disease and will also allow for exploration of the program of innate immune memory in health and disease. This information could be used to develop therapeutic agents to enhance the host response, preventing chronic inflammation through preserving tissues and signaling integrity.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (81273247, 81472655 and 31670905) and the Shanghai Municipal Education Commission key discipline support project 2015-10101001-1.

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Authors and Affiliations

  1. Faculty of Medical Laboratory Science, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Yiqun Hu, Feng Yan, Le Ying & Dakang Xu

  2. Institute of Ageing Research, Hangzhou Normal University School of Medicine, Hangzhou, China

    Feng Yan

  3. Department of Tea Science, Zhejiang University, Hangzhou, China

    Le Ying

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  1. Yiqun Hu
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  4. Dakang Xu
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Correspondence to Dakang Xu .

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  1. Faculty of Medical Laboratory Science, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Dakang Xu

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Hu, Y., Yan, F., Ying, L., Xu, D. (2017). Emerging Roles for Epigenetic Programming in the Control of Inflammatory Signaling Integration in Heath and Disease. In: Xu, D. (eds) Regulation of Inflammatory Signaling in Health and Disease. Advances in Experimental Medicine and Biology, vol 1024. Springer, Singapore. https://doi.org/10.1007/978-981-10-5987-2_3

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