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Medicinal Mushrooms with Antiallergic Activities

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Medicinal Plants and Fungi: Recent Advances in Research and Development

Part of the book series: Medicinal and Aromatic Plants of the World ((MAPW,volume 4))

Abstract

Allergies are an increasing problem worldwide, and new strategies for prophylaxis and therapy are urgently needed. Medicinal mushrooms present such an opportunity. Antiallergic activities have been found for Agaricus subrufescens, Armillaria ostoyae, Flammulina velutipes, Ganoderma lucidum and G. tsugae, Inonotus obliquus, Phellinus linteus, Pleurotus ostreatus and P. pulmonarius, Tricholoma populinum, and some further mushroom species. Nevertheless, most effects have been detected only in vitro and/or in animal assays, and responsible bioactive compounds have not yet been identified. Besides, only a limited number of mushroom species has been investigated for antiallergic activities until now. The chapter gives an overview about mushrooms with antiallergic activities and describes the challenges for the exploration of the antiallergic potential of mushrooms.

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Abbreviations

ACE:

Angiotensin-converting enzyme

cAMP:

Cyclic adenosine monophosphate

CD:

Cluster of differentiation

ConA:

Concanavalin A

DNP:

Dinitrophenyl

ED50 :

Median effective dose

ERK:

Extracellular-signal regulated kinase

FIP-fve :

Fungal immunomodulatory protein fve

i.p.:

Intraperitoneal

IC50 :

Half maximal inhibitory concentration

IFN:

Interferon

Ig:

Immunoglobulin

IL:

Interleukin

JNK:

C-Jun N-terminal kinase

MAPK:

Mitogen-activated protein kinase

OVA:

Ovalbumin

p.e.:

Parenteral

p.o.:

Per os (oral administration)

p38:

Protein 38

PMA:

Phorbol-12-myristate-13-acetate

RPMC:

Rat peritoneal mast cells

RRTI:

Recurrent respiratory tract infections SLIGRL-NH2

Agonist peptide derived from the N-terminus of protease-activated receptor 2

Syk:

Spleen tyrosine kinase

Th1/2 cells:

T helper cell subpopulations

TNFα:

Tumor necrosis factor α

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Authors and Affiliations

  1. Institute of Pharmacy, Pharmaceutical Biology, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17487, Greifswald, Germany

    Simon Merdivan & Ulrike Lindequist

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  1. Simon Merdivan
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  2. Ulrike Lindequist
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Correspondence to Simon Merdivan .

Editor information

Editors and Affiliations

  1. Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan

    Dinesh Chandra Agrawal

  2. Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan

    Hsin-Sheng Tsay

  3. Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan

    Lie-Fen Shyur

  4. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan

    Yang-Chang Wu

  5. Department of Forestry, National Chung Hsing University, Taichung, Taiwan

    Sheng-Yang Wang

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Merdivan, S., Lindequist, U. (2017). Medicinal Mushrooms with Antiallergic Activities. In: Agrawal, D., Tsay, HS., Shyur, LF., Wu, YC., Wang, SY. (eds) Medicinal Plants and Fungi: Recent Advances in Research and Development. Medicinal and Aromatic Plants of the World, vol 4. Springer, Singapore. https://doi.org/10.1007/978-981-10-5978-0_4

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