Abstract
Malaysia hosts a diverse range of medicinal plants having therapeutic values including anticancer properties. Over the years, a group of microorganisms called endophytes producing bioactive compounds similar to their host plants has been discovered. These endophytes, producing important compounds such as Taxol, L-asparaginase, and sclerotiorin, can be isolated and cultured in large scale to produce valuable compounds. This alternative approach of producing bioactive compounds is more sustainable than plants, as endophytes are renewable sources. In this chapter, endophytes from Malaysian medicinal plants have been discussed, highlighting the diversity of endophytes, the valuable compounds produced, the current methods used in biosourcing of endophytes, and the future prospects of anticancer agents derived from endophytes of Malaysian medicinal plants.
Keywords
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Abbreviations
- A549:
-
Human Caucasian lung carcinoma
- B16-F10:
-
Mouse skin melanoma
- CDK:
-
Cyclin-dependent kinase
- CEMss:
-
Human T4-lymphoblastoid cell line
- CPT:
-
Camptothecin
- D551:
-
Human normal skin cells
- DLD-1:
-
Human colorectal adenocarcinoma
- DNA:
-
Deoxyribonucleic acid
- ELISA:
-
Enzyme-linked immunosorbent assay
- HCT116:
-
Human colon carcinoma
- HeLa:
-
Human cervix carcinoma
- HepG2:
-
Human Caucasian hepatocyte carcinoma
- HPLC:
-
High-performance liquid chromatography
- K562:
-
Human chronic myeloid leukemia
- Kb:
-
Oral carcinoma cells
- LLC:
-
Lewis lung carcinoma
- M059J:
-
Human brain malignant glioma
- MCF-7:
-
Human breast adenocarcinoma
- MCM-B2:
-
Canine mammary carcinoma
- MDAMB231:
-
Human breast adenocarcinoma
- MG63:
-
Human bone osteosarcoma
- MS:
-
Mass spectrometry
- MTT:
-
3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
- NCI-H1299:
-
Human lung carcinoma
- NMR:
-
Magnetic resonance spectroscopy
- NPAA:
-
Nonprotein amino acids
- P388:
-
Murine leukemia cells
- PBLs:
-
Primary blood lymphocytes
- PC12:
-
Rat adrenal pheochromocytoma
- PC3:
-
Human prostate adenocarcinoma
- SkO-3:
-
Human Caucasian ovary adenocarcinoma
- T-47D:
-
Human breast ductal carcinoma
- TCM:
-
Traditional Chinese medicine
- WEHI-3:
-
Mouse leukemia cells
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Yap, LS., Lee, WL., Ting, ASY. (2017). Endophytes from Malaysian Medicinal Plants as Sources for Discovering Anticancer Agents. In: Agrawal, D., Tsay, HS., Shyur, LF., Wu, YC., Wang, SY. (eds) Medicinal Plants and Fungi: Recent Advances in Research and Development. Medicinal and Aromatic Plants of the World, vol 4. Springer, Singapore. https://doi.org/10.1007/978-981-10-5978-0_10
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