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Developments and Applications of Calcium Phosphate Bone Cements pp 257–298Cite as

Bioactivation of Calcium Phosphate Cement by Growth Factors and Their Applications

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Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 9))

Abstract

Calcium phosphate cement (CPC) scaffold has been widely used as bone graft substitutes. In order to deal with formidable defects in clinic, such as critical-sized bone defects or elderly patients with low regeneration capacity, a recombinant human bone morphogenetic protein-2 (rhBMP-2) was further loaded into CPC scaffold currently. In this chapter, effects of the surface properties, microstructure, and chemical composition on the bioactivity of rhBMP-2 were carried out. The osteogenic activity of CPC/rhBMP-2 in vitro and in vivo and the underlying mechanism were reported. Additionally, the clinical application of this active CPC/rhBMP-2 scaffold was also presented. These findings will provide insightful guide for the design and fabrication of rhBMP-2-based scaffolds/implants and further promote the clinical translation of growth factor-loaded porous scaffolds for bone regeneration.

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Acknowledgments

This work was supported by grants from the National Basic Research Program of China (973 Program, No. 2012CB933600), the 111 Project (B14018), and the National Natural Science Foundation of China (Nos. 31100679, 31330028, and 31470924).

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Authors and Affiliations

  1. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China

    Yifan Ma, Baolin Huang, Dan Lin & Yuan Yuan

  2. Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China

    Changsheng Liu

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  1. Yifan Ma
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  2. Baolin Huang
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  3. Dan Lin
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  4. Yuan Yuan
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Correspondence to Yuan Yuan .

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Editors and Affiliations

  1. Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China

    Changsheng Liu

  2. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China

    Hongyan He

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Ma, Y., Huang, B., Lin, D., Yuan, Y., Liu, C. (2018). Bioactivation of Calcium Phosphate Cement by Growth Factors and Their Applications. In: Liu, C., He, H. (eds) Developments and Applications of Calcium Phosphate Bone Cements. Springer Series in Biomaterials Science and Engineering, vol 9. Springer, Singapore. https://doi.org/10.1007/978-981-10-5975-9_6

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