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Developments and Applications of Calcium Phosphate Bone Cements pp 497–516Cite as

3D Printing of Calcium Phosphate Bio-scaffolds for Bone Therapy and Regeneration

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Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 9))

Abstract

Bone cancer brings patients great sufferings and puts an end to normal activities in life. In clinic, the most common treatment for bone cancer is the combination of surgery and chemo-/radiotherapy. However, surgery is difficult to eliminate tumor cells completely and results in large bone defect. Chemo-/radiotherapy is associated with chemo-/radioresistance and evident short-/long-term toxic effects. Therefore, the development of a novel bio-scaffold for local treatment of residual tumor cells and regeneration of bone defect induced by surgery has become a very urgent need. Some progress has been made in the development of scaffolds with the ability of both tumor therapy and bone regeneration. These scaffolds function as local agents and selectively kill the tumor cells via photothermal/magnetothermal therapy or local chemotherapy. Compared with traditional treatment, they have no side effects. In addition, scaffolds possess satisfactory biocompatibility, stimulating the migration, adhesion, proliferation, and differentiation of bone marrow stroma cells. Furthermore, they can promote gene expression of BMSCs and formation of new bone. Therefore, to bone tumor-suffering patients, it is a very meaningful progress in the biomedical application. Hopefully, more efforts and progress will be made in the development of scaffolds for the treatment of tumor-induced bone defects, and more research will continue to inform and guide this field.

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Acknowledgments

Funding for this study was provided by the Recruitment Program of Global Young Talent, China (Dr. Wu), National Key Research and Development Program of China (2016YFB0700803), the National High Technology Research and Development Program of China (863 Program, SS2015AA020302), Natural Science Foundation of China (Grant 81430012, 31370963), Key Research Program of Frontier Sciences, CAS (QYZDB-SSW-SYS027), and Program of Shanghai Outstanding Academic Leaders (15XD1503900).

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Authors and Affiliations

  1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China

    Hongshi Ma, Jiang Chang & Chengtie Wu

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  1. Hongshi Ma
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  2. Jiang Chang
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  3. Chengtie Wu
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Correspondence to Chengtie Wu .

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Editors and Affiliations

  1. Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China

    Changsheng Liu

  2. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China

    Hongyan He

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Ma, H., Chang, J., Wu, C. (2018). 3D Printing of Calcium Phosphate Bio-scaffolds for Bone Therapy and Regeneration. In: Liu, C., He, H. (eds) Developments and Applications of Calcium Phosphate Bone Cements. Springer Series in Biomaterials Science and Engineering, vol 9. Springer, Singapore. https://doi.org/10.1007/978-981-10-5975-9_12

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