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Importance of Biomaterials In Vivo Microenvironment pH (μe-pH) in the Regeneration Process of Osteoporotic Bone Defects

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Developments and Applications of Calcium Phosphate Bone Cements

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 9))

Abstract

In scenario of osteoporotic fracture, significantly higher activity of osteoclasts than osteoblasts may lead to continuous loss of bone in fracture/defect site. Impaired bone regeneration efficiency is the major barrier that influences endosseous implants to get a better performance, and this substantially increases the risk of a second fracture, nonunion, and aseptic implant loosening. Although great effects have been made, there are still no clinically approved biomaterials specifically tailored for applications in osteoporotic bones. The key issue for developing such biomaterials is to reestablish normal bone regeneration at the fracture site. Acid-base property could directly influence the behavior of bone cells, thus making it an important factor to modulate the unbalanced activity between osteoclast and osteoblast in osteoporotic conditions. More importantly, it is adjustable through implant biodegradation. Therefore, a rational strategy to reconstruct the regeneration balance in the fracture site is to regulate the microenvironmental pH (μe-pH) through the application of biodegradable materials. The present chapter provides an overview on how pH change influences bone cells behaviors as well as recent development on revealing the role of μe-pH in guiding the localized bone regeneration. We proposed that the μe-pH is an important and accessible factor which should be taken into consideration in the development of orthopedic biomaterials, in particular for repair of osteoporotic bone fracture/defect.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (No. 81672227; 51372170), Shenzhen Peacock Program (No. 110811003586331), Highlight research of frontier science, Chinese academy of sciences (No. QYZDB-SSW-JSC030), Shenzhen Science and Technology Research funding (No. CXZZ20150401152251209; JSGG2015103014032514; JSGG20150331154931068, CXZZ20140417113430716, JCYJ20170413162104773) and Youth Innovation Promotion Association CAS.

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  1. Research Center for Human Tissue and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

    Wenlong Liu & Haobo Pan

  2. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

    Xiuli Dan

  3. Department of Orthopaedics and Traumatology, Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

    William Weijia Lu

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  1. Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China

    Changsheng Liu

  2. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China

    Hongyan He

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Liu, W., Dan, X., Lu, W.W., Pan, H. (2018). Importance of Biomaterials In Vivo Microenvironment pH (μe-pH) in the Regeneration Process of Osteoporotic Bone Defects. In: Liu, C., He, H. (eds) Developments and Applications of Calcium Phosphate Bone Cements. Springer Series in Biomaterials Science and Engineering, vol 9. Springer, Singapore. https://doi.org/10.1007/978-981-10-5975-9_11

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