Preeclampsia pp 113-124 | Cite as

Obesity, Adipokines, and Lipokines

  • Katsuhiko NaruseEmail author
Part of the Comprehensive Gynecology and Obstetrics book series (CGO)


Obesity during pregnancy is increasing in frequency worldwide. Similar to other complications, obesity is a strong risk factor for hypertensive disorders in pregnancy (HDP). The mechanisms of this vicious cycle, unclear up to the last century, have recently been elucidated in the field of internal medicine, where adipose tissue was found to be an important endocrine organ in the human body that releases several immunoactive molecules in high concentrations. In addition to circulating lipids and lipids subjected to oxidative stress, novel cytokines derived from adipocytes or other cells of the adipose tissue (adipokines and lipokines) enhance the pathological effects of HDP. Some adipokines behave in HDP in the same way as in hypertension or metabolic syndrome in nonpregnant subjects, but a few adipokines in pregnancy or HDP act differently from insulin-resistant syndromes. In addition, during normal pregnancy, insulin resistance is an important process for fetal growth, labor, and breastfeeding, and molecules produced by adipose tissue seem to act an immunologically critical role in HDP.


Adipokine Adipose tissue Fatty acids Lipokine Obesity 


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.St. Barnabas’ HospitalOsaka CityJapan

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