Preeclampsia pp 209-224 | Cite as


  • Toshihiro TakizawaEmail author
  • Akihide Ohkuchi
  • Shigeki Matsubara
  • Toshiyuki Takeshita
  • Shigeru Saito
Part of the Comprehensive Gynecology and Obstetrics book series (CGO)


Aberrant expression of microRNAs (miRNAs) occurs in the preeclamptic placenta, where it causes dysregulation of functional molecules. The human placenta expresses a unique set of miRNAs (e.g., chromosome 19 miRNA cluster miRNAs). miRNAs, including placenta-specific miRNAs, are released from the placental villous trophoblast into the maternal circulation via exosomes. Because placenta-specific miRNAs are detectable in maternal blood, information about the placenta can be obtained during routine pregnancy screening via minimally invasive tests such as blood sampling, rather than highly invasive tests such as tissue biopsy. Radical treatment for preeclampsia (PE) is termination of the pregnancy, but in cases of early-onset PE, the pregnancy should be prolonged as long as possible to improve the infant’s prognosis. Prediction of PE in the first trimester could make it possible to prevent PE and develop novel therapeutic strategies to treat PE. This chapter explores the predictive utility of plasma placenta-specific miRNAs.


Placenta-specific microRNA Exosome Maternal plasma Early-onset preeclampsia 



This work was supported by Grants-in-Aids for Scientific Research and Private University Strategic Research Foundation Support Program (2013–2017) from the Ministry of Education, Culture, Sports, Science and Technology/Japan Society for the Promotion of Science, Japan.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Toshihiro Takizawa
    • 1
    Email author
  • Akihide Ohkuchi
    • 2
  • Shigeki Matsubara
    • 2
  • Toshiyuki Takeshita
    • 3
  • Shigeru Saito
    • 4
  1. 1.Department of Molecular Medicine and AnatomyNippon Medical SchoolTokyoJapan
  2. 2.Department of Obstetrics and GynecologyJichi Medical UniversityTochigiJapan
  3. 3.Department of Obstetrics and GynecologyNippon Medical SchoolTokyoJapan
  4. 4.Department of Obstetrics and Gynecology, Faculty of MedicineUniversity of ToyamaToyamaJapan

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