Novel Combinatorial Probiotics in Therapy and Prophylaxis



The microorganisms that are beneficial to health on consumption are known as probiotics, provided that they remain alive on consumption. The dosage and the administration regimen should be done considering the viability and survival of the microorganism in the acidic conditions prevailing in the stomach and intestinal region. Study of probiotics mainly involves the interaction of healthy microbiota and their associated interaction with host for health benefits. Studies implicated the effectiveness of live formulation of some lyophilized microorganisms such as Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei and Streptococcus thermophilus in small clinical trials. This chapter mainly highlights the use of probiotics in the inflammatory bowel disease (IBD). IBD includes two types of diseases: (i) Ulcerative colitis and (ii) Crohn’s disease. The common symptom of both the diseases involves severe diarrhoea, pain and weight loss. In ulcerative colitis, the patient develops ulcers in the innermost lining of the large intestine, colon and rectum and the resulting inflammation which sustains for longer duration of time. In Crohn’s disease, inflammation spreads out from the intestinal region and can affect entire gastrointestinal tract, i.e. from mouth to anus. As the rate of the prevalence of IBD is high in India and China, the novel approaches such as use of eco-compatible drugs are needed to combat the problems of antibiotic resistance.


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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Department of ZoologyUniversity of CalcuttaKolkataIndia

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