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Nanomaterials in Cancer Theranostics

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Bioactivity of Engineered Nanoparticles

Part of the book series: Nanomedicine and Nanotoxicology ((NANOMED))

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Abstract

Recent advances in the development of novel nanomaterials and evaluation of their biomedical applications have shown promises of those multifunctional nanomaterials in the development of new approaches for cancer detection and therapy. The unique physicochemical properties of nanomaterials, small size, and large surface-area-to-volume ratio endow them with novel multifunctional capabilities for cancer imaging, drug delivery, and cancer therapy, referred to as theranostics, which are different from the traditional diagnosis and therapy approaches. To facilitate the translation of nanomaterials as imaging agents and drug delivery carriers into clinical applications, great efforts have been made on designing and improving biocompatibility, stability, safety, drug loading ability, targeted delivery, imaging signals, and thermal- or photodynamic responses. With the development of companion new imaging techniques and therapeutic approaches, several nanomaterials have demonstrated great theranostic potential in image-guided therapy of diseases, especially in cancer therapy. In this review, the current status and perspective of nanoparticles in the development of cancer theranostic agents will be discussed with a focus on several representative nanomaterials, including magnetic iron oxide nanoparticles, gold nanoparticles, silica nanoparticles, polymeric nanoparticles, and carbon nanomaterials.

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Authors and Affiliations

  1. Department of Surgery, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Lei Zhu & Lily Yang

  2. Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China

    Zhiyang Zhou

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  1. Lei Zhu
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  2. Lily Yang
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Correspondence to Lei Zhu or Lily Yang .

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Editors and Affiliations

  1. School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China

    Bing Yan

  2. School of Environment, Jinan University, Guangzhou, Guangdong, China

    Hongyu Zhou

  3. Department of Chemistry, University of Texas at El Paso, El Paso, Texas, USA

    Jorge L. Gardea-Torresdey

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Zhu, L., Yang, L., Zhou, Z. (2017). Nanomaterials in Cancer Theranostics. In: Yan, B., Zhou, H., Gardea-Torresdey, J. (eds) Bioactivity of Engineered Nanoparticles. Nanomedicine and Nanotoxicology. Springer, Singapore. https://doi.org/10.1007/978-981-10-5864-6_8

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