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Hypertension and Stroke

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Book cover Translational Research in Stroke

Part of the book series: Translational Medicine Research ((TRAMERE))

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Abstract

Hypertension is considered as the most important contributor to stroke patients among all the risk factors. Over 70% of stroke patients accompany with chronic hypertension. Hypertension could induce the brain vascular system change, and these changes likely impair brain blood flow autoregulation and contribute to the increased infarct size after vessel occlusion. As the preclinical researches developed, a better understanding is emerging of how hypertension induces damage of the cerebrovascular dysfunction, raising the possibility of protecting the brain from the ravages of hypertension. The mechanisms that high blood pressure increased incidence and severity of stroke in hypertensive patients remain poorly understand. The appropriate blood control will promote function and potentially repair ischemia damaged of stroke patients. By examining hypertension and antihypertensive treatments in hypertensive animal stroke models, we may develop a better understanding of how to manage hypertension in the acute stroke setting. And with our constantly broaden understanding of hypertensive mechanisms, scientist now have the opportunity to develop new strategies to control blood pressure in the acute stroke therapy or chronic blood pressure management after stroke, which could help recovery or prevent stroke recurrence.

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Abbreviations

AHA:

American Heart Association

AngII:

Angiotensin II

AS:

Arterial stiffening

BBB:

Blood-brain barrier

BP:

Blood pressure

DBP:

Diastolic blood pressure

EPCs:

Endothelial progenitor cells

L-NAME:

L-nitroarginine methyl ester

MCAO:

Middle cerebral artery occlusion

MSCs:

Mesenchymal stem cells

RHRSP:

Stroke-prone renovascular hypertensive rats

SBP:

Systolic blood pressure

SHRs:

Spontaneously hypertensive rats

SHRSP:

Stroke-prone spontaneously hypertensive rats

WKY:

Wistar-Kyoto rat

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Authors and Affiliations

  1. State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Vascular Biology, Department of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, People’s Republic of China

    Jun Huang & Pingjin Gao

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  1. Jun Huang
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  2. Pingjin Gao
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Correspondence to Pingjin Gao .

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Editors and Affiliations

  1. Department of Neurology & Neurosurgery, Cedars-Sinai Medical Center, Advanced Health Sciences Pavilion, Los Angeles, California, USA

    Paul A. Lapchak

  2. Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

    Guo-Yuan Yang

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Huang, J., Gao, P. (2017). Hypertension and Stroke. In: Lapchak, P., Yang, GY. (eds) Translational Research in Stroke. Translational Medicine Research. Springer, Singapore. https://doi.org/10.1007/978-981-10-5804-2_8

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