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Gene Therapy for Stroke

  • Chapter
  • First Online:
Translational Research in Stroke

Part of the book series: Translational Medicine Research ((TRAMERE))

  • 1145 Accesses

Abstract

Ischemic stroke is one of the leading causes of death in the world. Current treatment option is limited by therapeutic time window. Gene transfer might be a potential strategy to decrease neurologic dysfunction after stroke. In this chapter, we discussed status of gene therapy for ischemic stroke, available vectors, potential targets, therapeutic genes, and delivery methods.

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Abbreviations

AAV:

Adeno-associated virus

Ad:

Adenoviral virus

ANG:

Angiopoietins

BBB:

Blood-brain barrier

BDNF:

Brain-derived neurotrophic factor

CNS:

Central nerve system

EGF:

Epidermal growth factor

eNOS:

Endothelial nitric oxide synthase

EPO:

Erythropoietin

FGF:

Fibroblast growth factors

G-CSF:

Granulocyte colony-stimulating factor

GPE:

Glycine-proline-glutamate

GSH peroxidase:

Glutathione peroxidase

HO-1:

Heme oxygenase-1

HREs:

Hypoxia response elements

Hsp70:

Heat-shock protein 70

HSV:

Herpes simplex virus

IA:

Intra-arterial

IGF-1:

Insulin-like growth factor-1

iPSCs:

Induced pluripotent stem cells

IV:

Intravenous

MCAO:

Middle cerebral artery occlusion

MHPs:

Microglial healing peptides

miRNAs:

MicroRNAs

MMLV:

Melony murine leukemia virus

MMP:

Matrix metalloproteinase

MSCs:

Bone marrow mesenchymal stromal cells

NMDA:

N-methyl-D-aspartate

Nox1:

Nitrogen oxides

NSC:

Neural stem cell

NT3:

Neurotrophin-3

ODNs:

Antisense oligodeoxynucleotides

PEG:

Polyethylene glycol

PPE-EA:

Polyaminoethyl propylene phosphate

RA-NP:

Retinoic acid-loaded nanoparticles

ROS:

Reactive oxygen species

RTL1000:

T-cell receptor ligand 1000

rtPA:

Recombinant tissue plasminogen activator

SGZ:

Subgranular zone

SHR-SP:

Stroke-prone spontaneously hypertensive rat

siRNAs:

Small interference RNAs

SOD:

Superoxide dismutase

SVZ:

Subventricular zone

TAT:

Transactivating transcriptional activator

TGF:

Transforming growth factors

Th:

Type-2 helper T cells

TJs:

Tight junctions

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Department of Neurology & Institute of Neurology, Rui Jin and Rui Jin North Hospital, Shanghai Jiao Tong University, Shanghai, 200025, China

    Fanxia Shen

  2. Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, 1001 Potrero Avenue, Box 1363, San Francisco, CA, 94143, USA

    Hua Su

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  1. Fanxia Shen
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Correspondence to Hua Su .

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Editors and Affiliations

  1. Department of Neurology & Neurosurgery, Cedars-Sinai Medical Center, Advanced Health Sciences Pavilion, Los Angeles, California, USA

    Paul A. Lapchak

  2. Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

    Guo-Yuan Yang

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Shen, F., Su, H. (2017). Gene Therapy for Stroke. In: Lapchak, P., Yang, GY. (eds) Translational Research in Stroke. Translational Medicine Research. Springer, Singapore. https://doi.org/10.1007/978-981-10-5804-2_20

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