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Kaposi’s Sarcoma-Associated Herpesvirus: Epidemiology and Molecular Biology

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Book cover Infectious Agents Associated Cancers: Epidemiology and Molecular Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1018))

Abstract

Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as Human herpesvirus 8 (HHV-8), is a member of the lymphotropic gammaherpesvirus subfamily and a human oncogenic virus. Since its discovery in AIDS-associated KS tissues by Drs. Yuan Chang and Patrick Moore, much progress has been made in the past two decades. There are four types of KS including classic KS, endemic KS, immunosuppressive therapy-related KS, and AIDS-associated KS. In addition to KS, KSHV is also involved in the development of primary effusion lymphoma (PEL) and certain types of multicentric Castleman’s disease. KSHV manipulates numerous viral proteins to promote the progression of angiogenesis and tumorigenesis. In this chapter, we review the epidemiology and molecular biology of KSHV and the mechanisms underlying KSHV-induced diseases.

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Acknowledgments

This work was supported by grants from the Natural Science Foundation for Distinguished Young Scholar (81425017), the Ministry of Science and Technology of China (2016YFA0502100), the Key Project of the National Natural Science Foundation of China (81230037), and the National Institutes of Health (1R01AI116442) to Ke Lan.

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  1. State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, People’s Republic of China

    Shasha Li & Ke Lan

  2. Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, People’s Republic of China

    Lei Bai, Jiazhen Dong & Rui Sun

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  1. Shasha Li
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  2. Lei Bai
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  3. Jiazhen Dong
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Correspondence to Ke Lan .

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  1. Key Laboratory of Medical Molecular Virology (Ministries of Education and Health), School of Basic Medical Science Fudan University, Shanghai, China

    Qiliang Cai

  2. Key Laboratory of Medical Molecular Virology (Ministries of Education and Health), School of Basic Medical Science Fudan University, Shanghai, China

    Zhenghong Yuan

  3. State Key Laboratory of Virology, College of Life Science, Wuhan University, Wuhan, China

    Ke Lan

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Li, S., Bai, L., Dong, J., Sun, R., Lan, K. (2017). Kaposi’s Sarcoma-Associated Herpesvirus: Epidemiology and Molecular Biology. In: Cai, Q., Yuan, Z., Lan, K. (eds) Infectious Agents Associated Cancers: Epidemiology and Molecular Biology. Advances in Experimental Medicine and Biology, vol 1018. Springer, Singapore. https://doi.org/10.1007/978-981-10-5765-6_7

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