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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1018))

Abstract

Bacterial infections were traditionally not considered as major causes of cancer. However, increasing evidence in the past decades has suggested that several cancers are highly associated with bacterial infection. The bacterial infections have evolved some unique strategies including lateral gene transfer, biofilm and microbiome to induce genome instability and chronic inflammation, as well as escape of immune surveillance for carcinogenesis. Here we summarize and highlight the recent progress on understanding of how bacterial infection plays a role in tumor formation and malignancy.

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References

  1. Kuper H, Adami HO, Trichopoulos D (2000) Infections as a major preventable cause of human cancer. J Intern Med 248:171–183

    Article  CAS  PubMed  Google Scholar 

  2. Ness RB, Cauley JA (2004) Antibiotics and breast cancer – what’s the meaning of this? JAMA 291:880–881

    Article  CAS  PubMed  Google Scholar 

  3. Harris RE, Beebe-Donk J, Doss H, Burr DD (2005) Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review). Oncol Rep 13:559–583

    CAS  PubMed  Google Scholar 

  4. Onuigbo WI (1975) Some nineteenth century ideas on links between tuberculous and cancerous diseases of the lung. Br J Dis Chest 69:207–210

    Article  CAS  PubMed  Google Scholar 

  5. Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK (1991) Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 325:1127–1131

    Article  CAS  PubMed  Google Scholar 

  6. Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, Isaacson PG (1991) Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 338:1175–1176

    Article  CAS  PubMed  Google Scholar 

  7. Mikulska M, Viscoli C, Orasch C, Livermore DM, Averbuch D, Cordonnier C, Akova M, Fourth European Conference on Infections in Leukemia Group ajvoEEIELN, Esgich/Escmid (2014) Aetiology and resistance in bacteraemias among adult and paediatric haematology and cancer patients. J Infect 68:321–331

    Article  PubMed  Google Scholar 

  8. Mentis A, Lehours P, Megraud F (2015) Epidemiology and diagnosis of helicobacter pylori infection. Helicobacter 20(Suppl 1):1–7

    Article  PubMed  Google Scholar 

  9. Ding Z, Zhao S, Gong S, Li Z, Mao M, Xu X, Zhou L (2015) Prevalence and risk factors of helicobacter pylori infection in asymptomatic Chinese children: a prospective, cross-sectional, population-based study. Aliment Pharmacol Ther 42:1019–1026

    Article  CAS  PubMed  Google Scholar 

  10. Marshall BJ, Warren JR (1984) Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1:1311–1315

    Article  CAS  PubMed  Google Scholar 

  11. Weeks DL, Eskandari S, Scott DR, Sachs G (2000) A H+−gated urea channel: the link between helicobacter pylori urease and gastric colonization. Science 287:482–485

    Article  CAS  PubMed  Google Scholar 

  12. Peek RM Jr, Blaser MJ (2002) Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nature reviews. Cancer 2:28–37

    CAS  PubMed  Google Scholar 

  13. Peek RM Jr, Crabtree JE (2006) Helicobacter infection and gastric neoplasia. J Pathol 208:233–248

    Article  CAS  PubMed  Google Scholar 

  14. Sena Teixeira Mendes L, DA A, CW A (2014) Helicobacter pylori infection in gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma: a re-evaluation. Gut 63:1526–1527

    Article  PubMed  Google Scholar 

  15. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, Taniyama K, Sasaki N, Schlemper RJ (2001) Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 345:784–789

    Article  CAS  PubMed  Google Scholar 

  16. Mera R, Fontham ET, Bravo LE, Bravo JC, Piazuelo MB, Camargo MC, Correa P (2005) Long term follow up of patients treated for helicobacter pylori infection. Gut 54:1536–1540

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Wong BC, Lam SK, Wong WM, Chen JS, Zheng TT, Feng RE, Lai KC, Hu WH, Yuen ST, Leung SY, Fong DY, Ho J, Ching CK, Chen JS, China Gastric Cancer Study G (2004) Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA 291:187–194

    Article  CAS  PubMed  Google Scholar 

  18. Huret JL, Ahmad M, Arsaban M, Bernheim A, Cigna J, Desangles F, Guignard JC, Jacquemot-Perbal MC, Labarussias M, Leberre V, Malo A, Morel-Pair C, Mossafa H, Potier JC, Texier G, Viguie F, Yau Chun Wan-Senon S, Zasadzinski A, Dessen P (2013) Atlas of genetics and cytogenetics in oncology and haematology in 2013. Nucleic Acids Res 41:D920–D924

    Article  CAS  PubMed  Google Scholar 

  19. Song H, Ekheden IG, Zheng Z, Ericsson J, Nyren O, Ye W (2015) Incidence of gastric cancer among patients with gastric precancerous lesions: observational cohort study in a low risk western population. BMJ 351:h3867

    Article  PubMed  PubMed Central  Google Scholar 

  20. Zackular JP, Baxter NT, Iverson KD, Sadler WD, Petrosino JF, Chen GY, Schloss PD (2013) The gut microbiome modulates colon tumorigenesis. MBio 4:e00692–e00613

    Article  PubMed  PubMed Central  Google Scholar 

  21. Sears CL, Garrett WS (2014) Microbes, microbiota, and colon cancer. Cell Host Microbe 15:317–328

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Flynn KJ, Baxter NT, Schloss PD (2016) Metabolic and community synergy of oral bacteria in colorectal cancer. mSphere 1

    Google Scholar 

  23. Binder Gallimidi A, Fischman S, Revach B, Bulvik R, Maliutina A, Rubinstein AM, Nussbaum G, Elkin M (2015) Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget 6:22613–22623

    Article  PubMed  Google Scholar 

  24. Yu J, Feng Q, Wong SH, Zhang D, Liang QY, Qin Y, Tang L, Zhao H, Stenvang J, Li Y, Wang X, Xu X, Chen N, Wu WK, Al-Aama J, Nielsen HJ, Kiilerich P, Jensen BA, Yau TO, Lan Z, Jia H, Li J, Xiao L, Lam TY, Ng SC, Cheng AS, Wong VW, Chan FK, Xu X, Yang H, Madsen L, Datz C, Tilg H, Wang J, Brunner N, Kristiansen K, Arumugam M, Sung JJ, Wang J (2017) Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer. Gut 66:70–78

    Article  PubMed  Google Scholar 

  25. Zeller G, Tap J, Voigt AY, Sunagawa S, Kultima JR, Costea PI, Amiot A, Bohm J, Brunetti F, Habermann N, Hercog R, Koch M, Luciani A, Mende DR, Schneider MA, Schrotz-King P, Tournigand C, Tran Van Nhieu J, Yamada T, Zimmermann J, Benes V, Kloor M, Ulrich CM, von Knebel DM, Sobhani I, Bork P (2014) Potential of fecal microbiota for early-stage detection of colorectal cancer. Mol Syst Biol 10:766

    Article  PubMed  PubMed Central  Google Scholar 

  26. Whitmore SE, Lamont RJ (2014) Oral bacteria and cancer. PLoS Pathog 10:e1003933

    Article  PubMed  PubMed Central  Google Scholar 

  27. Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL, Rossetti BJ, Peterson SN, Snesrud EC, Borisy GG, Lazarev M, Stein E, Vadivelu J, Roslani AC, Malik AA, Wanyiri JW, Goh KL, Thevambiga I, Fu K, Wan F, Llosa N, Housseau F, Romans K, Wu X, McAllister FM, Wu S, Vogelstein B, Kinzler KW, Pardoll DM, Sears CL (2014) Microbiota organization is a distinct feature of proximal colorectal cancers. Proc Natl Acad Sci U S A 111:18321–18326

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Warren RL, Freeman DJ, Pleasance S, Watson P, Moore RA, Cochrane K, Allen-Vercoe E, Holt RA (2013) Co-occurrence of anaerobic bacteria in colorectal carcinomas. Microbiome 1:16

    Article  PubMed  PubMed Central  Google Scholar 

  29. Hajishengallis G (2015) Periodontitis: from microbial immune subversion to systemic inflammation. Nature reviews. Immunology 15:30–44

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Donaldson GP, Lee SM, Mazmanian SK (2016) Gut biogeography of the bacterial microbiota. Nature reviews. Microbiology 14:20–32

    CAS  PubMed  Google Scholar 

  31. Rubinstein MR, Wang X, Liu W, Hao Y, Cai G, Han YW (2013) Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin. Cell Host Microbe 14:195–206

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, El-Omar EM, Brenner D, Fuchs CS, Meyerson M, Garrett WS (2013) Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 14:207–215

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Johnson CH, Dejea CM, Edler D, Hoang LT, Santidrian AF, Felding BH, Ivanisevic J, Cho K, Wick EC, Hechenbleikner EM, Uritboonthai W, Goetz L, Casero RA Jr, Pardoll DM, White JR, Patti GJ, Sears CL, Siuzdak G (2015) Metabolism links bacterial biofilms and colon carcinogenesis. Cell Metab 21:891–897

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Nagy KN, Sonkodi I, Szoke I, Nagy E, Newman HN (1998) The microflora associated with human oral carcinomas. Oral Oncol 34:304–308

    Article  CAS  PubMed  Google Scholar 

  35. Michaud DS (2013) Role of bacterial infections in pancreatic cancer. Carcinogenesis 34:2193–2197

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Groeger S, Domann E, Gonzales JR, Chakraborty T, Meyle J (2011) B7-H1 and B7-DC receptors of oral squamous carcinoma cells are upregulated by Porphyromonas gingivalis. Immunobiology 216:1302–1310

    Article  CAS  PubMed  Google Scholar 

  37. Inaba H, Sugita H, Kuboniwa M, Iwai S, Hamada M, Noda T, Morisaki I, Lamont RJ, Amano A (2014) Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation. Cell Microbiol 16:131–145

    Article  CAS  PubMed  Google Scholar 

  38. Uitto VJ, Baillie D, Wu Q, Gendron R, Grenier D, Putnins EE, Kanervo A, Firth JD (2005) Fusobacterium nucleatum increases collagenase 3 production and migration of epithelial cells. Infect Immun 73:1171–1179

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Bodro M, Gudiol C, Garcia-Vidal C, Tubau F, Contra A, Boix L, Domingo-Domenech E, Calvo M, Carratala J (2014) Epidemiology, antibiotic therapy and outcomes of bacteremia caused by drug-resistant ESKAPE pathogens in cancer patients. Support Care Cancer: Off J Multinatl Assoc Support Care Cancer 22:603–610

    Article  Google Scholar 

  40. Rolston KV, Besece D, Lamp KC, Yoon M, McConnell SA, White P (2014) Daptomycin use in neutropenic patients with documented gram-positive infections. Support Care Cancer: Off J Multinatl Assoc Support Care Cancer 22:7–14

    Article  Google Scholar 

  41. Dix D, Cellot S, Price V, Gillmeister B, Ethier MC, Johnston DL, Lewis V, Michon B, Mitchell D, Stobart K, Yanofsky R, Portwine C, Silva M, Bowes L, Zelcer S, Brossard J, Traubici J, Allen U, Beyene J, Sung L (2012) Association between corticosteroids and infection, sepsis, and infectious death in pediatric acute myeloid leukemia (AML): results from the Canadian infections in AML research group. Clin Infect Dis: Off Publ Infect Dis Soc Am 55:1608–1614

    Article  CAS  Google Scholar 

  42. Lewis V, Yanofsky R, Mitchell D, Dix D, Ethier MC, Gillmeister B, Johnston D, Michon B, Stobart K, Portwine C, Silva M, Cellot S, Price V, Bowes L, Zelcer S, Brossard J, Beyene J, Sung L (2014) Predictors and outcomes of viridans group streptococcal infections in pediatric acute myeloid leukemia: from the Canadian infections in AML research group. Pediatr Infect Dis J 33:126–129

    Article  PubMed  Google Scholar 

  43. Shelburne SA 3rd, Tarrand J, Rolston KV (2013) Review of streptococcal bloodstream infections at a comprehensive cancer care center, 2000–2011. J Infect 66:136–146

    Article  PubMed  Google Scholar 

  44. Domenech A, Ardanuy C, Grau I, Calatayud L, Pallares R, Fenoll A, Brueggemann AB, Linares J (2014) Evolution and genetic diversity of the Spain23F-ST81 clone causing adult invasive pneumococcal disease in Barcelona (1990–2012). J Antimicrob Chemother 69:924–931

    Article  CAS  PubMed  Google Scholar 

  45. Han SB, Bae EY, Lee JW, Lee DG, Chung NG, Jeong DC, Cho B, Kang JH, Kim HK (2013) Clinical characteristics and antimicrobial susceptibilities of viridans streptococcal bacteremia during febrile neutropenia in patients with hematologic malignancies: a comparison between adults and children. BMC Infect Dis 13:273

    Article  PubMed  PubMed Central  Google Scholar 

  46. Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, Craig AS, Schaffner W, Zansky SM, Gershman K, Stefonek KR, Albanese BA, Zell ER, Schuchat A, Schrag SJ, Active Bacterial Core surveillance/Emerging Infections Program N (2008) Epidemiology of invasive group B streptococcal disease in the United States, 1999–2005. JAMA 299:2056–2065

    Article  CAS  PubMed  Google Scholar 

  47. Richter SS, Heilmann KP, Dohrn CL, Riahi F, Diekema DJ, Doern GV (2013) Pneumococcal serotypes before and after introduction of conjugate vaccines, United States, 1999–2011(1.) Emerg Infect Dis 19:1074–1083

    Article  PubMed  PubMed Central  Google Scholar 

  48. Noble CJ (1978) Carriage of group D streptococci in the human bowel. J Clin Pathol 31:1182–1186

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Kupferwasser I, Darius H, Muller AM, Mohr-Kahaly S, Westermeier T, Oelert H, Erbel R, Meyer J (1998) Clinical and morphological characteristics in Streptococcus bovis endocarditis: a comparison with other causative microorganisms in 177 cases. Heart 80:276–280

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Mc CW, Mason JM 3rd (1951) Enterococcal endocarditis associated with carcinoma of the sigmoid; report of a case. J Med Assoc State Ala 21:162–166

    Google Scholar 

  51. Tjalsma H, Scholler-Guinard M, Lasonder E, Ruers TJ, Willems HL, Swinkels DW (2006) Profiling the humoral immune response in colon cancer patients: diagnostic antigens from Streptococcus bovis. Int J Cancer 119:2127–2135

    Article  CAS  PubMed  Google Scholar 

  52. Zhou X, Arends JP, Span LF, Friedrich AW (2013) Algorithm for pre-emptive glycopeptide treatment in patients with haematologic malignancies and an Enterococcus faecium bloodstream infection. Antimicrob Resist Infect Control 2:24

    Article  PubMed  PubMed Central  Google Scholar 

  53. Welton JC, Marr JS, Friedman SM (1979) Association between hepatobiliary cancer and typhoid carrier state. Lancet 1:791–794

    Article  CAS  PubMed  Google Scholar 

  54. Tewari M, Mishra RR, Shukla HS (2010) Salmonella typhi and gallbladder cancer: report from an endemic region. Hepatobiliary Pancreat Dis Int: HBPD INT 9:524–530

    CAS  PubMed  Google Scholar 

  55. Robinson KM, Sieber KB, Dunning Hotopp JC (2013) A review of bacteria-animal lateral gene transfer may inform our understanding of diseases like cancer. PLoS Genet 9:e1003877

    Article  PubMed  PubMed Central  Google Scholar 

  56. Koehler JE, Sanchez MA, Garrido CS, Whitfeld MJ, Chen FM, Berger TG, Rodriguez-Barradas MC, LeBoit PE, Tappero JW (1997) Molecular epidemiology of bartonella infections in patients with bacillary angiomatosis-peliosis. N Engl J Med 337:1876–1883

    Article  CAS  PubMed  Google Scholar 

  57. Schroder G, Schuelein R, Quebatte M, Dehio C (2011) Conjugative DNA transfer into human cells by the VirB/VirD4 type IV secretion system of the bacterial pathogen Bartonella henselae. Proc Natl Acad Sci U S A 108:14643–14648

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Riley DR, Sieber KB, Robinson KM, White JR, Ganesan A, Nourbakhsh S, Dunning Hotopp JC (2013) Bacteria-human somatic cell lateral gene transfer is enriched in cancer samples. PLoS Comput Biol 9:e1003107

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Handa O, Naito Y, Yoshikawa T (2011) Redox biology and gastric carcinogenesis: the role of Helicobacter pylori. Redox Rep: Commun Free Radic Res 16:1–7

    Article  CAS  Google Scholar 

  60. El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, Herrera J, Lissowska J, Yuan CC, Rothman N, Lanyon G, Martin M, Fraumeni JF Jr, Rabkin CS (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 404:398–402

    Article  CAS  PubMed  Google Scholar 

  61. Martin C, Thevenot G, Danel S, Chapron J, Tazi A, Macey J, Dusser DJ, Fajac I, Burgel PR (2011) Pseudomonas aeruginosa induces vascular endothelial growth factor synthesis in airway epithelium in vitro and in vivo. Eur Respir J 38:939–946

    Article  CAS  PubMed  Google Scholar 

  62. Takayama S, Takahashi H, Matsuo Y, Okada Y, Takeyama H (2010) Effect of Helicobacter bilis infection on human bile duct cancer cells. Dig Dis Sci 55:1905–1910

    Article  PubMed  Google Scholar 

  63. Mori N, Wada A, Hirayama T, Parks TP, Stratowa C, Yamamoto N (2000) Activation of intercellular adhesion molecule 1 expression by Helicobacter pylori is regulated by NF-kappaB in gastric epithelial cancer cells. Infect Immun 68:1806–1814

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Isomoto H, Mizuta Y, Miyazaki M, Takeshima F, Omagari K, Murase K, Nishiyama T, Inoue K, Murata I, Kohno S (2000) Implication of NF-kappaB in Helicobacter pylori-associated gastritis. Am J Gastroenterol 95:2768–2776

    CAS  PubMed  Google Scholar 

  65. Hold GL, Rabkin CS, Chow WH, Smith MG, Gammon MD, Risch HA, Vaughan TL, McColl KE, Lissowska J, Zatonski W, Schoenberg JB, Blot WJ, Mowat NA, Fraumeni JF Jr, El-Omar EM (2007) A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gastroenterology 132:905–912

    Article  CAS  PubMed  Google Scholar 

  66. Coschi CH, Dick FA (2012) Chromosome instability and deregulated proliferation: an unavoidable duo. Cell Mol Life Sci: CMLS 69:2009–2024

    Article  CAS  PubMed  Google Scholar 

  67. Lax AJ (2005) Opinion: bacterial toxins and cancer – a case to answer? Nature reviews. Microbiology 3:343–349

    CAS  PubMed  Google Scholar 

  68. Patyar S, Joshi R, Byrav DS, Prakash A, Medhi B, Das BK (2010) Bacteria in cancer therapy: a novel experimental strategy. J Biomed Sci 17:21

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Oswald E, Sugai M, Labigne A, Wu HC, Fiorentini C, Boquet P, O’Brien AD (1994) Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin stress fibers. Proc Natl Acad Sci U S A 91:3814–3818

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Lax AJ, Thomas W (2002) How bacteria could cause cancer: one step at a time. Trends Microbiol 10:293–299

    Article  CAS  PubMed  Google Scholar 

  71. Finlay BB, McFadden G (2006) Anti-immunology: evasion of the host immune system by bacterial and viral pathogens. Cell 124:767–782

    Article  CAS  PubMed  Google Scholar 

  72. Sarantis H, Grinstein S (2012) Subversion of phagocytosis for pathogen survival. Cell Host Microbe 12:419–431

    Article  CAS  PubMed  Google Scholar 

  73. Nitsche-Schmitz DP, Johansson HM, Sastalla I, Reissmann S, Frick IM, Chhatwal GS (2007) Group G streptococcal IgG binding molecules FOG and protein G have different impacts on opsonization by C1q. J Biol Chem 282:17530–17536

    Article  CAS  PubMed  Google Scholar 

  74. Torres VJ, VanCompernolle SE, Sundrud MS, Unutmaz D, Cover TL (2007) Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets. J Immunol 179:5433–5440

    Article  CAS  PubMed  Google Scholar 

  75. Gebert B, Fischer W, Weiss E, Hoffmann R, Haas R (2003) Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science 301:1099–1102

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Qiliang Cai .

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Zhu, C., Wang, Y., Cai, C., Cai, Q. (2017). Bacterial Infection and Associated Cancers. In: Cai, Q., Yuan, Z., Lan, K. (eds) Infectious Agents Associated Cancers: Epidemiology and Molecular Biology. Advances in Experimental Medicine and Biology, vol 1018. Springer, Singapore. https://doi.org/10.1007/978-981-10-5765-6_11

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