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Malignancies in HIV-Infected and AIDS Patients

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Infectious Agents Associated Cancers: Epidemiology and Molecular Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1018))

Abstract

Currently, HIV infection and AIDS are still one of the most important epidemic diseases around the world. As early in the initial stage of HIV epidemic, the high incidence of ADCs including Kaposi sarcoma and non-Hodgkin’s lymphoma was the substantial amount of disease burden of HIV infection and AIDS. With the increasing accessibility of HAART and improving medical care for HIV infection and AIDS, AIDS-related illness including ADCs has dramatically decreased. Meanwhile, the incidence of NADCs rises in PLWH. Compared with the general population, most of cancers are more likely to attack PLWH, and NADCs in PLWH were characterized as earlier onset and more aggressive. However, the understanding for cancer development in PLWH is still dimness. Herein, we reviewed the current knowledge of epidemiology and pathogenesis for malignancies in PLWH summarized from recent studies. On the basis of that, we discussed the special considerations for cancer treatment in PLWH. As those malignancies could be the major issue for HIV infection or AIDS in the future, we expect enhanced investigations, surveillances, and clinical trial for improving the understanding and management for cancers developed in PLWH.

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Authors and Affiliations

  1. Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, People’s Republic of China

    Yongjia Ji & Hongzhou Lu

  2. Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China

    Hongzhou Lu

  3. Department of Internal Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, People’s Republic of China

    Hongzhou Lu

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  1. Yongjia Ji
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Correspondence to Hongzhou Lu .

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Editors and Affiliations

  1. Key Laboratory of Medical Molecular Virology (Ministries of Education and Health), School of Basic Medical Science Fudan University, Shanghai, China

    Qiliang Cai

  2. Key Laboratory of Medical Molecular Virology (Ministries of Education and Health), School of Basic Medical Science Fudan University, Shanghai, China

    Zhenghong Yuan

  3. State Key Laboratory of Virology, College of Life Science, Wuhan University, Wuhan, China

    Ke Lan

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Ji, Y., Lu, H. (2017). Malignancies in HIV-Infected and AIDS Patients. In: Cai, Q., Yuan, Z., Lan, K. (eds) Infectious Agents Associated Cancers: Epidemiology and Molecular Biology. Advances in Experimental Medicine and Biology, vol 1018. Springer, Singapore. https://doi.org/10.1007/978-981-10-5765-6_10

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