Abstract
The eye like any other organ in the body can harbor tumors of different types. Given the diverse anatomy of the eye, each distinct structure within the eye can be the site for primary tumors; that is, those tumors arising from the native tissue or metastatic tumors: those that arise from a distant site in the body. With reference to the eye and adnexa, metastatic tumors have been documented in the orbit, the extraocular muscles, conjunctiva, subconjunctival tissue, iris, and the retina with the most common site being the choroid [1]. This chapter presents in detail the clinical presentation, diagnosis, imaging findings, and treatment of retinal and choroidal metastases.
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References
Avram AM, Gielczyk R, Su L, Vine AK, Sisson JC. Choroidal and skin metastases from papillary thyroid cancer: case and a review of the literature. J Clin Endocrinol Metab. 2004;89(11):5303–7.
Shields CL, Shields JA, Gross NE, Schwartz GP, Lally SE. Survey of 520 eyes with uveal metastases. Ophthalmology. 1997;104(8):1265–76.
Shields CL. Plaque radiotherapy for the management of uveal metastasis. Curr Opin Ophthalmol. 1998;9(3):31–7.
Albert DM, Rubenstein RA, Scheie HG. Tumor metastasis to the eye. I. Incidence in 213 adult patients with generalized malignancy. Am J Ophthalmol. 1967;63(4):723–6.
Bloch RS, Gartner S. The incidence of ocular metastatic carcinoma. Arch Ophthalmol. 1971;85(6):673–5.
Eliassi-Rad B, Albert DM, Green WR. Frequency of ocular metastases in patients dying of cancer in eye bank populations. Br J Ophthalmol. 1996;80(2):125–8.
Kreusel K-M, Wiegel T, Stange M, Bornfeld N, Hinkelbein W, Foerster MH. Choroidal metastasis in disseminated lung cancer: frequency and risk factors. Am J Ophthalmol. 2002;134(3):445–7.
Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery lecture, part 1. Ophthalmology. 2004;111(5):997–1008.
Ferry AP, Font RL. Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases. Arch Ophthalmol. 1974;92(4):276–86.
Freedman MI, Folk JC. Metastatic tumors to the eye and orbit. Patient survival and clinical characteristics. Arch Ophthalmol. 1987;105(9):1215–9.
Stephens RF, Shields JA. Diagnosis and management of cancer metastatic to the uvea: a study of 70 cases. Ophthalmology. 1979;86(7):1336–49.
Shah SU, Mashayekhi A, Shields CL, et al. Uveal metastasis from lung cancer: clinical features, treatment, and outcome in 194 patients. Ophthalmology. 2014;121(1):352–7.
Mack HG, Jakobiec FA. Isolated metastases to the retina or optic nerve. Int Ophthalmol Clin. 1997;37(4):251–60.
Klein R, Nicholson DH, Luxenberg MN. Retinal metastasis from squamous cell carcinoma of the lung. Am J Ophthalmol. 1977;83(3):358–61.
Letson AD, Davidorf FH. Bilateral retinal metastases from cutaneous malignant melanoma. Arch Ophthalmol. 1982;100(4):605–7.
Schmidt D, Ness T, Geissler M. Cotton-wool spots associated with pancreatic carcinoma. Eur J Med Res. 2001;6(3):101–4.
Demirci H, Shields CL, Chao A-N, Shields JA. Uveal metastasis from breast cancer in 264 patients. Am J Ophthalmol. 2003;136(2):264–71.
Shields CL, McMahon JF, Atalay HT, Hasanreisoglu M, Shields JA. Retinal metastasis from systemic cancer in 8 cases. JAMA Ophthalmol. 2014;132(11):1303–8.
Lizzi FL, Coleman DJ. History of ophthalmic ultrasound. J Ultrasound Med. 2004;23(10):1255–66.
Sobottka B, Schlote T, Krumpaszky HG, Kreissig I. Choroidal metastases and choroidal melanomas: comparison of ultrasonographic findings. Br J Ophthalmol. 1998;82:159–61.
Witkin AJ, Fischer DH, Shields CL, Reichstein D, Shields JA. Enhanced depth imaging spectral-domain optical coherence tomography of a subtle choroidal metastasis. Eye. 2012;26(12):1598–9.
Shields CL, Pellegrini M, Ferenczy S. Enhanced depth imaging optical coherence tomography of intraocular tumors: from placid to seasick to rock and rolling topography – the 2013 Francesco Orzalesi Lecture. Retina. 2014;34:1495–512.
Arevalo JF, Fernandez CF, Reinaldo GA. Optical coherence tomography characteristics of choroidal metastasis. Ophthalmology. 2005;112(9):1612–9.
Arepalli S, Kaliki S, Shields CL. Choroidal metastases: origin, features, and therapy. Indian J Ophthalmol. 2015;63(2):122–7.
Demirci H, Cullen A, Sundstrom JM. Enhanced depth imaging optical coherence tomography of choroidal metastasis. Retina. 2014;34(7):1354–9.
Shields CL, Manalac J, Chandana D, Saktanaste D. Review of spectral domain enhanced depth imaging optical coherence tomography of tumors of the choroid. Indian J Ophthalmol. 2015;63(2):117–22.
Al-Dahmash SA, Shields CL, Kaliki S, Johnson T, Shields JA. Enhanced depth imaging optical coherence tomography of choroidal metastasis in 14 eyes. Retina. 2014;34:1588–93.
Li L, Wang WJ, Chen RJ, Qian J, Luo CQ. Fundus fluorescein angiography in metastatic choroidal carcinomas and differentiating metastatic choroidal carcinomas from primary choroidal melanomas. Zhonghua Yan Ke Za Zhi. 2011;47(1):27–34.
Ditmar S, Holtz FG. Choroidal metastases. In: Fluorescence angiography in ophthalmology. Berlin: Springer; 2008. p. 214–5.
Jia Y, Bailey ST, Wilson DJ, Tan O. Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration. Ophthalmology. 2014;121(7):1435–44.
Ishibazawa A, Nagaoka T, Takahashi A, Omae T. Optical coherence tomography angiography in diabetic retinopathy: a prospective pilot study. Am J Ophthalmol. 2015;160(1):35–44.
Singh P, Singh A. Choroidal melanoma. Oman J Ophthalmol. 2012;5(1):3–9.
Natesh S, Chin K, Finger PT. Choroidal metastases fundus autofluorescence imaging: correlation to clinical, OCT, and fluorescein angiographic findings. Ophthalmic Surg Lasers Imaging. 2010;41(4):406–12.
Collet LC, Pulido JS, Gunduz K, Diago T. Fundus autofluorescence in choroidal metastatic lesions: a pilot study. Retina. 2008;28(9):1251–6.
Almeida A, Kaliki S, Shields CL. Autofluorescence of intraocular tumors. Curr Opin Ophthalmol. 2013;24(3):222–32.
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Nair, A.G., Fell, D., Raouf, S., Kaliki, S. (2018). Imaging of Retinal and Choroidal Metastases. In: Chhablani, J., Majumder, P., Arevalo, J. (eds) Retinal and Choroidal Imaging in Systemic Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-10-5461-7_10
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