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Debates in Dacryology: The Mitomycin C Dilemma

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Principles and Practice of Lacrimal Surgery

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Abstract

The most common reason for the failure of dacryocystorhinostomy (DCR) surgery is the formation of scar or granulation tissue over the osteotomy site. From the literature, it is clear that fibrous tissue growth, scarring, and granulation tissue formation during the healing process will decrease or compromise the created surface area of the osteotomy site, leading to surgical failure. Also, the healing process has the potential to promote adhesion of the middle turbinate and septum to the osteotomy site or induce an obstruction of the common canaliculus. Thus, if we can inhibit fibrous tissue growth and scarring by applying antiproliferative agents over the anastomosed flaps and osteotomy site, the failure rate may be minimized. This chapter will examine these aspects in the light of current literature.

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Authors and Affiliations

  1. Department of Ophthalmology, Zhongshan Hospital and Fudan University, Shanghai, China

    Yi-Fan Feng M.D., Ph.D.

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  1. Yi-Fan Feng M.D., Ph.D.
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Correspondence to Yi-Fan Feng M.D., Ph.D. .

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Editors and Affiliations

  1. Govindram Seksaria Insitute of Dacryology, L.V.Prasad Eye Institute, Hyderabad, India

    Mohammad Javed Ali

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Feng, YF. (2018). Debates in Dacryology: The Mitomycin C Dilemma. In: Ali, M. (eds) Principles and Practice of Lacrimal Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-10-5442-6_44

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  • DOI: https://doi.org/10.1007/978-981-10-5442-6_44

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  • Online ISBN: 978-981-10-5442-6

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