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Electron Microscopy of the Lacrimal System

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Abstract

Ultrastructural studies help in understanding the tissue functions and aberrations at a cellular and subcellular level. It is carried out using electron microscopy: scanning electron microscopy or transmission electron microscopy. Very few studies have looked at the ultrastructural features for lacrimal drainage system. The current chapter would provide an overview of recent works in the lacrimal drainage system and the vast potential to do more in this area.

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References

  1. Radnot M. Ultrastructure of the lacrimal sac. Ann Ophthalmol. 1972;4:1050–7.

    CAS  PubMed  Google Scholar 

  2. Radnot M. The cilia of the lacrimal sac epithelium – SEM studies. Klin Monatsbl Augenheilkd. 1977;170:428–30.

    CAS  PubMed  Google Scholar 

  3. Adenis JP, Loubet A, Leboutet MJ, et al. Ultrastructural aspect of different levels of the lacrimal system. J Fr Ophthalmol. 1980;3:343–8.

    CAS  Google Scholar 

  4. Adenis JP, Loubet A, Leboutet MJ, et al. Ultrastructural morphology at the different levels of the lacrimal passage mucosa. Arch Anat Cytol Pathol. 1980;28:371–5.

    CAS  PubMed  Google Scholar 

  5. Radnot M. The fine structure of the oncocytes of the lacrimal sac. Klin Monatsbl Augenheilkd. 1981;179:249–50.

    Article  CAS  PubMed  Google Scholar 

  6. Thale A, Paulsen F, Rochels R, et al. Functional anatomy of the human efferent tear ducts: a new theory of tear outflow mechanism. Graefes Arch Clin Exp Ophthalmol. 1998;236:674–8.

    Article  CAS  PubMed  Google Scholar 

  7. Paulsen FP, Thale A, Hallmann UJ, et al. The cavernous body of human efferent tear ducts: function in tear outflow mechanism. Invest Ophthalmol Vis Sci. 2000;41:965–70.

    CAS  PubMed  Google Scholar 

  8. Paulsen F. The human nasolacrimal ducts. Adv Anat Embryol Cell Biol. 2003;170:1–106.

    Article  Google Scholar 

  9. Ali MJ, Baig F, Lakshman M, et al. Scanning electron microscopic features of the external and internal surfaces of normal adult lacrimal drainage system. Ophthal Plast Reconstr Surg. 2015;31:414–7.

    Google Scholar 

  10. Ali MJ, Mishra DK, Baig F, et al. Punctal stenosis: histopathology, immunology and electron microscopic features – a step towards unraveling the mysterious etiopathogenesis. Ophthal Plast Reconstr Surg. 2015;31:98–102.

    Google Scholar 

  11. Dave TV, Mohammed FA, Ali MJ, et al. Etiologic analysis of 100 failed anatomical dacryocystorhinostomies. Clin Ophthalmol. 2016;10:1419–22.

    Google Scholar 

  12. Ali MJ, Psaltis AJ, Wormald PJ. Long-term outcomes in revision powered endoscopic dacryocystorhinostomies. Int Forum Allergy Rhinol. 2014;4:1016–9.

    Google Scholar 

  13. Watelet JB, Bachert C, Gevaert P, et al. Wound healing of the nasal and paranasal mucosa: a review. Am J Rhinol. 2002;16:77–84.

    PubMed  Google Scholar 

  14. Ali MJ, Mishra DK, Baig F, et al. Histopathology, immunohistochemistry, and electron microscopic features of a dacryocystorhinostomy ostium cicatrix. Ophthal Plast Reconstr Surg. 2016;32:333–6.

    Google Scholar 

  15. Xue K, Mellington FE, Norris JH. Meta-analysis of the adjunctive use of mitomycin C in primary and revision, external and endonasal dacryocystorhinostomy. Orbit. 2014;33:239–44.

    Article  PubMed  Google Scholar 

  16. Feng YF, Yu JG, Shi JL, et al. A meta-analysis of primary external dacryocystorhinostomy with and without mitomycin C. Ophthalmic Epidemiol. 2012;19:364–70.

    Article  PubMed  Google Scholar 

  17. Ali MJ, Mariappan I, Maddileti S, et al. Mitomycin C in dacryocystorhinostomy: the search for the right concentration and duration – a fundamental study on human nasal mucosa fibroblasts. Ophthal Plast Reconstr Surg. 2013;29:469–74.

    Google Scholar 

  18. Kumar V, Ali MJ, Ramachandran C. Effect of mitomycin-C on contraction and migration of human nasal mucosa fibroblasts: implications in dacryocystorhinostomy. Br J Ophthalmol. 2015;99:1295–300.

    Google Scholar 

  19. Nair AG, Ali MJ. Mitomycin-C in dacryocystorhinostomy: from experimentation to implementation and the road ahead: a review. Indian J Ophthalmol. 2015;63:335–9.

    Google Scholar 

  20. Kamal S, Ali MJ, Naik MN. Circumostial mitomycin C (COS-MMC) in external and endoscopic dacryocystorhinostomy: efficacy, safety profiles and outcomes. Ophthal Plast Reconstr Surg. 2014;30:187–90.

    Google Scholar 

  21. Singh M, Ali MJ, Naik MN. Long-term outcomes of circumostial injection of mitomycin C (COS-MMC) in dacryocystorhinostomy. Ophthal Plast Reconstr Surg. 2015;31:423–4.

    Google Scholar 

  22. Ali MJ, Baig F, Lakshman M, et al. Electron microscopic features of nasal mucosa treated with topical and circumostial injection of mitomycin C: implications in dacryocystorhinostomy. Ophthal Plast Reconstr Surg. 2015;31:103–7.

    Google Scholar 

  23. Unlu H, Aslan A, Toprak B, et al. Comparison of surgical outcomes in primary endoscopic dacryocystorhinostomy with and without silicone intubation. Ann Otol Rhinol Laryngol. 2002;111:704–9.

    Article  PubMed  Google Scholar 

  24. Feng YF, Cai JQ, Zhang JY, et al. A meta-analysis of primary dacryocystorhinostomy with and without silicone intubation. Can J Ophthalmol. 2011;46:521–7.

    Article  PubMed  Google Scholar 

  25. Moscato EE, Dolmetsch AM, Silkiss RZ, Seiff SR. Silicone intubation for the treatment of epiphora in adults with presumed functional nasolacrimal duct obstruction. Ophthal Plast Reconstr Surg. 2012;28:35–9.

    Article  PubMed  Google Scholar 

  26. Kim SE, Lee J, Lee SY. Clinical significance of the microbial growth on the surfaces of silicone tubes removed from dacryocystorhinostomy patients. Am J Ophthalmol. 2012;153:253–7.

    Article  PubMed  Google Scholar 

  27. Ali MJ, Manderwad G, Naik MN. The microbiological spectrum and antibiotic sensitivity profile of extubated silicone stents following dacryocystorhinostomy. Orbit. 2013;32:298–303.

    Google Scholar 

  28. Murphy J, Ali MJ, Psaltis AJ. Biofilm quantification on nasolacrimal silastic stents after dacryocystorhinostomy. Ophthal Plast Reconstr Surg. 2015;31:396–400.

    Google Scholar 

  29. Ramadan HH, Sanclemann JA, Thomas JG. Chronic rhinosinusitis and biofilms. Otolaryngol Head Neck Surg. 2005;132:414–7.

    Article  PubMed  Google Scholar 

  30. Samimi B, Bielory BP, Miller D, et al. Microbiological trends and biofilm growth on explanted periorbital biomaterials: a 30 year review. Ophthal Plast Reconstr Surg. 2013;29:376–81.

    Article  PubMed  Google Scholar 

  31. Ali MJ, Baig F, Lakshman M, et al. Biofilms and physical deposits on nasolacrimal silastic stents following dacryocystorhinostomy: is there a difference between ocular and nasal segments? Ophthal Plast Reconstr Surg. 2015;31:452–5.

    Google Scholar 

  32. Ali MJ, Baig F, Lakshman M, et al. Scanning electron microscopic features of extubated monoka stents. Ophthal Plast Reconstr Surg. 2017;33(2):90–2.

    Google Scholar 

  33. Ali MJ, Baig F, Naik MN. Electron microscopic features of intraluminal portion of nasolacrimal silastic stents following dacryocystorhinostomy. Is there a need for stents without a lumen? Ophthal Plast Reconstr Surg. 2016;32:252–6.

    Google Scholar 

  34. Ali MJ, Baig F, Lakshman M, et al. Scanning electron microscopic features of nasolacrimal silastic stents retained for prolong durations following dacryocystorhinostomy. Ophthal Plast Reconstr Surg. 2016;32:20–3.

    Google Scholar 

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Correspondence to Mohammad Javed Ali F.R.C.S. .

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Ali, M.J. (2018). Electron Microscopy of the Lacrimal System. In: Ali, M. (eds) Principles and Practice of Lacrimal Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-10-5442-6_42

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  • DOI: https://doi.org/10.1007/978-981-10-5442-6_42

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-5441-9

  • Online ISBN: 978-981-10-5442-6

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