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Cell Culture and Observation on Microfluidics

Chapter
Part of the Integrated Analytical Systems book series (ANASYS)

Abstract

Recent advances in microfluidic systems have led to the development of on-chip culture and observation. The on-chip culture offers several advantages over conventional in vitro culture methods: Reduced cell and reagent consumption, more accurate mimicking of in vivo cellular microenvironment, integrating function modules and controllable mechanical and chemical factors. These advantages support the microfluidic applications in biological science, especially for cellular dynamic study. Based on transparent characteristics of chip substrate, the microfluidic devices can be easily coupled to cell imaging methods and realize bio-application in cellomics. In this chapter, we introduce the development of microfluidic culture and how the microfluidic devices work in cell observations, especially for cell biology.

Keywords

Microfluidic cell culture Non-destructive observations Cell biology applications 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.School of ScienceBeijing University of Chemical TechnologyBeijingChina
  2. 2.Department of ChemistryTsinghua UniversityBeijingPeople’s Republic of China

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