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Emergence of Multidrug-Resistant Bacteria in Freshwater Ecosystems (River) and Screening of Natural Therapeutics Against the Probable Drug Targets of Drug-Resistant Pathogens by Computational Biology Approaches

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Recent advances in Applied Microbiology

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Abstract

Due to enormous accumulation of industrial effluents and wastes from various sources, the natural status of many freshwater bodies has distorted and created an ideal atmosphere for survival and swift proliferation of many bacterial pathogens. Major populations of these bacteria are coliforms, and they obtain additional characters due to the rapid changes in their chromosomal DNA; a major concern is the acquisition of drug-resistant genes. The emergence of multidrug resistance in these bacteria has become critical issue in many freshwater ecosystems globally. The conventional drugs against these bacteria are not effective therapeutic strategies which necessitates alternative therapeutic approaches. Computer-assisted drug discovery plays a profound role in screening novel herbal-based leads and similar natural leads against the probable drug targets such as drug-resistant gene products and toxins of the pathogenic bacteria. This chapter illustrates the recent concerns and issues related with water pollution in freshwater ecosystems and emphasizes major causes of the emergence of bacterial drug resistance in such water bodies. Further, it investigates the utility of many natural compounds especially herbal-based ligands as lead molecules against the probable drug targets of multidrug-resistant bacterial pathogens by computer-aided virtual screening.

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References

  • Aatish P (2012) Cauvery water dispute essay (www.publishyourarticles.org/eng). Accessed 25 Mar 2014

  • Akoachere JF, Masalla TN, Njom HA (2013) Multi-drug resistant toxigenic Vibrio cholerae O1 is persistent in water sources in New Bell-Douala, Cameroon. BMC Infect Dis 13:366. doi:10.1186/1471-2334-13-366

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ali MS, Osman GA (2010) Microbial load as pollution indicator in water of El-Khadra Lake at Wadi El-Natroun, Egypt. J Am Sci 6:489–496

    Google Scholar 

  • Baker GJ (2014) Christianity and eugenics: the place of religion in the British eugenics education society and the American eugenics society, c.1907-1940. Soc Hist Med 27:281–302

    Article  PubMed  PubMed Central  Google Scholar 

  • Bauer AW, Perry DM, Kirby WMM (1959) Single-disk antibiotic-sensitivity testing of staphylococci: an analysis of technique and results. AMA Arch Intern Med 104:208–216

    Article  CAS  PubMed  Google Scholar 

  • Belay A, Sahile S (2013) The effects of Dashen brewery wastewater treatment effluent on the bacteriological and physicochemical quality of Shinta River in Gondar, North West Ethiopia. World Environ 3:29–36

    Google Scholar 

  • Berglund B (2015) Environmental dissemination of antibiotic resistance genes and correlation to anthropogenic contamination with antibiotics. Infect Ecol Epidemiol 5:28564

    Article  PubMed  Google Scholar 

  • Bharath EN, Manjula SN, Vijaychand A (2011) In silico drug design tool for overcoming the innovation deficit in the drug discovery process. Int J Pharm Pharm Sci 3:8–12

    Google Scholar 

  • Bouraie MME, Barbary AAE, Yehia MM, Motawea EA (2011) Water quality of Rosetta branch in Nile delta, Egypt. Suo 61:1–12

    Google Scholar 

  • Briskin DP (2000) Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiol 124:507–514

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brylinski M, Waldrop GL (2014) Computational redesign of bacterial biotin carboxylase inhibitors using structure-based virtual screening of combinatorial libraries. Molecules 19:4021–4045

    Article  PubMed  CAS  Google Scholar 

  • Butler MS, Cooper MA (2011) Antibiotics in the clinical pipeline in 2011. J Antibiot (Tokyo) 64:413–425

    Article  CAS  Google Scholar 

  • Carey RO, Migliaccio KW (2009) Contribution of wastewater treatment plant effluents to nutrient dynamics in aquatic systems: a review. Environ Manag 44:205–217

    Article  Google Scholar 

  • Chah KF, Eze CA, Emuelosi CE, Esimone CO (2006) Antibacterial and wound healing properties of methanolic extracts of some Nigerian medicinal plants. J Ethnopharmacol 104:164–167

    Article  CAS  PubMed  Google Scholar 

  • Chapman D (1996) Water quality assessments: a guide to the use of biota, sediments and water in environmental monitoring, 2nd edn. Chapman & Hall, London

    Book  Google Scholar 

  • Chen CY, Lindsey RL, Strobaugh TP Jr, Frye JG, Meinersmann RJ, Chen CY, Lindsey RL, Strobaugh TP Jr, Frye JG, Meinersmann RJ (2010) Prevalence of ColE1-like plasmids and kanamycin resistance genes in Salmonella enterica serovars. Appl Environ Microbiol 76:6707–6714

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chigor VN, Sibanda T, Okoh AI (2013) Studies on the bacteriological qualities of the Buffalo River and three source water dams along its course in the Eastern Cape Province of South Africa. Environ Sci Pollut Res Int 20:4125–4136

    Article  CAS  PubMed  Google Scholar 

  • Chowdhury S (2012) Heterotrophic bacteria in drinking water distribution system: a review. Environ Monit Assess 184:6087–6137

    Article  CAS  PubMed  Google Scholar 

  • Chung BK, Dick T, Lee DY (2013) In silico analyses for the discovery of tuberculosis drug targets. J Antimicrob Chemother 68:2701–2709

    Article  CAS  PubMed  Google Scholar 

  • Coleman BL, Louie M, Salvadori MI, McEwen SA, Neumann N, Sibley K, Irwin RJ, Jamieson FB, Daignault D, Majury A, Braithwaite S, Crago B, McGeer AJ (2013) Contamination of Canadian private drinking water sources with antimicrobial resistant Escherichia coli. Water Res 47:3026–3036

    Article  CAS  PubMed  Google Scholar 

  • Colonna P, Leloup V, Buléon A (1992) Limiting factors of starch hydrolysis. Eur J Clin Nutr 46:S17–S32

    PubMed  Google Scholar 

  • Central Pollution Control Board (CPCB), Annual Report-2012, Ministry of Environment & Forests (http://www.cpcb.nic.in/upload/AnnualReports). Accessed 1 Apr 2015

  • Dahiya P, Purkayastha S (2012) Phytochemical screening and antimicrobial activity of some medicinal plants against multi-drug resistant bacteria from clinical isolates. Indian J Pharm Sci 74:443–450

    Article  PubMed  PubMed Central  Google Scholar 

  • Dahiya T, Baweja M, Shukla P (2014) A swift description on antimicrobial action of Sarcostemma intermedium, an extraordinary scarce medicinal plant against few pathogenic microorganisms. Res J Pharm Biol Chem Sci 5(2):1064–1069

    Google Scholar 

  • Daniels R (2011) Surviving the first hours in sepsis: getting the basics right (an intensivist's perspective). J Antimicrob Chemother 66:11–23

    Article  CAS  Google Scholar 

  • Dhanik A, Kavraki LE (2012) Protein–ligand interactions: computational docking. In: eLS. Wiley, Chichester

    Google Scholar 

  • Dorice K, Joséphine N, Margaret TA, Gaston L, Beyala KK, Bessa A, Henriette, Emmanuel EG (2010) Bacterial contamination of water points of the upper Mfoundi watershed, Yaounde, Cameroon. Afr J Microbio Res 4:568–574

    Google Scholar 

  • Downing LS, Nerenberg R (2008) Effect of bulk liquid BOD concentration on activity and microbial community structure of a nitrifying, membrane-aerated biofilm. Appl Microbiol Biotechnol 81:153–162

    Article  CAS  PubMed  Google Scholar 

  • Dudarev AA, Dushkina EV, Sladkova YN, Alloyarov PR, Chupakhin VS, Dorofeyev VM, Kolesnikova TA, Fridman KB, Evengard B, Nilsson LM (2013) Food and water security issues in Russia II: water security in general population of Russian Arctic, Siberia and Far East, 2000-2011. Int J Circumpolar Health 72:22646. doi:10.3402/ijch.v72i0.22646

    Article  PubMed  Google Scholar 

  • Dudgeon D, Arthington AH, Gessner MO, Kawabata Z, Knowler DJ, Lévêque C, Naiman RJ, Prieur-Richard AH, Soto D, Stiassny ML, Sullivan CA (2006) Freshwater biodiversity: importance, threats, status and conservation challenges. Biol Rev Camb Philos Soc 81:163–182

    Article  PubMed  Google Scholar 

  • Fahnoe KC, Flanagan ME, Gibson G, Shanmugasundaram V, Che Y, Tomaras AP (2012) Non-traditional antibacterial screening approaches for the identification of novel inhibitors of the glyoxylate shunt in gram-negative pathogens. PLoS One 7:e51732

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gago F (2004) Modelling and simulation: a computational perspective in anticancer drug discovery. Curr Med Chem Anticancer Agents 4:401–403

    Article  CAS  PubMed  Google Scholar 

  • Galvão LC, Furletti VF, Bersan SM, da Cunha MG, Ruiz AL, de Carvalho JE, Sartoratto A, Rehder VL, Figueira GM, Teixeira Duart MC, Ikegaki M, de Alencar SM, Rosale PL (2012) Antimicrobial activity of essential oils against Streptococcus mutans and their antiproliferative effects. Evid Based Complement Alternat Med 2012:751435

    Article  PubMed  PubMed Central  Google Scholar 

  • Gao P, Mao D, Luo Y, Wanga L, Xu B, Xu L (2012) Occurrence of sulfonamide and tetracycline-resistant bacteria and resistance genes in aquaculture environment. Water Res 46:2355–2364

    Article  CAS  PubMed  Google Scholar 

  • Garcia SN, Clubbs RL, Stanley JK, Scheffe B, Yelderman JC Jr, Brooks BW (2013) Comparative analysis of effluent water quality from a municipal treatment plant and two on-site wastewater treatment systems. Chemosphere 92:38–44

    Article  CAS  PubMed  Google Scholar 

  • García-Armisen T, InceoÄŸlu O, Ouattara NK, Anzil A, Verbanck MA, Brion N, Servais P (2014) Seasonal variations and resilience of bacterial communities in a sewage polluted urban river. PLoS One 9:e92579

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gazzaz MN, Yusoff KM, Ramli MF, Aris AZ, Juahir HA (2012) Characterization of special patterns in river water quality using chemo metric pattern recognition techniques. Mar Pollut Bull 64:688–698

    Article  CAS  PubMed  Google Scholar 

  • Girija TR, Mahanta C, Chandramouli V (2007) Water quality assessment of an untreated effluent impacted urban stream: the Bharalu tributary of the Brahmaputra River, India. Environ Monit Assess 130:221–236

    Article  CAS  PubMed  Google Scholar 

  • Glynn MK, Bopp C, Dewitt W, Dabney P, Mokhtar M, Angulo FJ (1998) Emergence of multidrug-resistant Salmonella enterica serotype typhimurium DT104 infections in the United States. N Engl J Med 338:1333–1338

    Article  CAS  PubMed  Google Scholar 

  • Gowrishankar S, Thenmozhi R, Balaji K, Pandian SK (2013) Emergence of methicillin-resistant, vancomycin-intermediate Staphylococcus aureus among patients associated with group A Streptococcal pharyngitis infection in southern India. Infect. Genet Evol 14:83–389

    Article  Google Scholar 

  • Gupta A, Fontana J, Crowe C, Bolstorff B, Stout A, Duyne SV, Hoekstra MP, Whichard JM, Barrett TJ, Angulo FJ (2003) Emergence of multidrug-resistant Salmonella enterica serotype Newport infections resistant to expanded-spectrum cephalosporins in the United States. J Infect Dis 188:1707–1716

    Article  CAS  PubMed  Google Scholar 

  • Highsmith AK, Abshire RL (1975) Evaluation of a most probable- number technique for the enumeration of Pseudomonas Aeruginosa. Appl Microbiol 30:596–601

    CAS  PubMed  PubMed Central  Google Scholar 

  • Holt JG, Bergey DH, Breed RS (eds) (1993) Bergey's manual of determinative bacteriology, 9th edn. Lippincott Williams and Wilkins, Baltimore

    Google Scholar 

  • Hysko M, Gace B, Puto K (2010) Microbial water pollution of Vjosa River and the vegetable contamination by irrigation. In: BALWOIS-international conference on water, climate and environment, water observation and information system for decision support, Ohrid, Republic of Macedonia, 25–29 May

    Google Scholar 

  • Jalal FN, Kumar S (2013) Water quality assessment of Pamba River of Kerala, India in relation to pilgrimage season. Int J Res Chem Environ 3:341–347

    CAS  Google Scholar 

  • Jorgensen JH, Lee JC, Alexander GA, Wolf HW (1979) Comparison of Limulus assay, standard plate count, and total coliform count for microbiological assessment of renovated wastewater. Appl Environ Microbiol 37:928–931

    CAS  PubMed  PubMed Central  Google Scholar 

  • Joseph PV, Jacob C (2010) Physicochemical characteristics of Pennar River, a fresh water wetland in Kerala, India. E-Journal of Chemistry 7:1266–1273

    Article  CAS  Google Scholar 

  • Kadouri DE, To K, Shanks RM, Doi Y (2013) Predatory bacteria: a potential ally against multidrug-resistant gram-negative pathogens. PLoS One 8:e63397. doi:10.1371/journal.pone.0063397

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kapetanovic IM (2008) Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approach. Chem Biol Interact 171:165–176

    Article  CAS  PubMed  Google Scholar 

  • Karumuri S, Singh PK, Shukla P (2015) In Silico analog design for terbinafine against Trichophyton rubrum: a preliminary study. Ind J Microbiol 55(3):333–340. doi:10.1007/s12088-015-0524-x

    Article  CAS  Google Scholar 

  • Kotze PJ (2012) Aspects of water quality, metal contamination of sediment and fish in the Olifants River, Mpumalanga. Thesis (M. Sc.), Rand Afrikaans University, 1997

    Google Scholar 

  • Karnataka State Pollution Control Board (KSPCB) (2010) Annual report-August 2010 (http://kspcb.kar.nic.in/notifications.htm). Accessed on Jan 2014

  • Kuitcha D, Kamgang KBV, Sigha NL, Lienou G, Ekodeck GE (2008) Water supply, sanitation and health risks in Yaoundé, Cameroon. Afr J Envir Sc Technol 2:379–386

    Google Scholar 

  • Kumar V, Sharma A, Chawla A, Bhardwaj R, Thukral AK (2016) Water quality assessment of river Beas, India, using multivariate and remote sensing techniques. Environ Monit Assess 188(3):137. doi:10.1007/s10661-016-5141-6

    Article  CAS  PubMed  Google Scholar 

  • Lee Y (2013) An evaluation of microbial and chemical contamination sources related to the deterioration of tap water quality in the household water supply system. Int J Environ Res Public Health 10:4143–4160

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lee DY, Lee H, Trevors JT, Weir SC, Thomas JL, Habash M (2014) Characterization of sources and loadings of fecal pollutants using microbial source tracking assays in urban and rural areas of the Grand River watershed, Southwestern Ontario. Water Res 53:123–1231

    Article  PubMed  CAS  Google Scholar 

  • Lim HS, Lee LY, Bramono SE (2013) Community-based wastewater treatment systems and water quality of an Indonesian village. J Water Health 12:196–209

    Article  CAS  Google Scholar 

  • Luo Y, Yang F, Mathieu J, Mao D, Wang Q, Alvarez PJJ (2014) Proliferation of multidrug-resistant New Delhi Metallo-β-lactamase genes in municipal wastewater treatment plants in Northern China. Environ Sci Technol Lett 1:26–30

    Article  CAS  Google Scholar 

  • Lupo A, Coyne S, Berendonk TU (2012) Origin and evolution of antibiotic resistance: the common mechanisms of emergence and spread in water bodies. Front Microbiol 3:1–13

    Article  Google Scholar 

  • Lyskov S, Gray JJ (2008) The Rosetta Dock server for local protein-protein docking. Nucleic Acids Res 36:W233–W238

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mac Faddin JF (2000) Biochemical tests for identification of medical bacteria, 3rd edn. Williams and Wilkins, Baltimore, Lippincott

    Google Scholar 

  • Mandal SM, Porto WF, De D, Phule A, Korpole S, Ghosh AK, Roy SK, Franco OL (2014) Screening of serine protease inhibitors with antimicrobial activity using iron oxide nanoparticles functionalized with dextran conjugated trypsin and in silico analyses of bacterial serine protease inhibition. Analyst 139:464–472

    Article  CAS  PubMed  Google Scholar 

  • Marathe NP, Regina VR, Walujkar SA, Charan SS, Moore ER, Larsson DG, Shouche YS (2013) A treatment plant receiving waste water from multiple bulk drug manufacturers is a reservoir for highly multi-drug resistant integron-bearing bacteria. PLoS One 8:e77310

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Margot J, Kienle C, Magnet A, Weil M, Rossi L, de Alencastro LF, Abegglen C, Thonney D, Chèvre N, Schärer M, Barry DA (2014) Treatment of micropollutants in municipal wastewater: ozone or powdered activated carbon? Sci Total Environ 461-462:480–498

    Article  CAS  Google Scholar 

  • Marti E, Balcázar JL (2012) Multidrug resistance-encoding plasmid from Aeromonas sp. strain P2G1. Clin Microbiol Infect 18:E366–E368

    Article  CAS  PubMed  Google Scholar 

  • Marti-Renom MA, Stuart A, Fiser A, Sánchez R, Melo F, Sali A (2000) Comparative protein structure modeling of genes and genomes. Annu Rev Biophys Biomol Struct 29:291–325

    Article  CAS  PubMed  Google Scholar 

  • Moeller V (1955) Simplified tests for some amino acid decarboxylases and for the arginine dihydrolase system. Acta Pathol Microbiol Scand 36:158–172

    Article  Google Scholar 

  • Muller A, Mac Callum RM, Sternberg MJ (1999) Benchmarking PSI- BLAST in genome annotation. J Mol Biol 293:1257–1271

    Article  CAS  PubMed  Google Scholar 

  • Murakami K, Doi M, Yoshida T (1982) Asparenomycins A, B and C, new carbapenem antibiotics. J Antibiot (Tokyo) 35:32–38

    Article  Google Scholar 

  • Murray PR, Baron JH, Pfaller MA, Jorgensen JH, Yolken RH (eds) (2003) Manual of clinical microbiology, 8th edn. American Society for Microbiology, Washington, DC

    Google Scholar 

  • Nair R, Kalariya T, Chanda S (2005) Antibacterial activity of some selected Indian medicinal flora. Turk J Biol 29:41–47

    Google Scholar 

  • Ndjama J, Kamgang KBV, Sigha NL, Ekodeck GE, Tita MA (2008) Water supply, sanitation and health risks in Douala, Cameroon. Afr J Environ Sc Technol 2:422–429

    Google Scholar 

  • Nigam VK, Shukla P (2015) Enzyme based biosensors for detection of environmental pollutants-a review. Microb Biotechnol 25(11):1773–1781

    Article  CAS  Google Scholar 

  • O'Neill AJ (2008) New antibacterial agents for treating infections caused by multi-drug resistant gram-negative bacteria. Expert Opin Investig Drugs 17:297–302

    Article  CAS  PubMed  Google Scholar 

  • OsiÅ„ska A, Harnisz M, Korzeniewska E (2016) Prevalence of plasmid-mediated multidrug resistance determinants in fluoroquinolone-resistant bacteria isolated from sewage and surface water. Environ Sci Pollut Res Int 23(11):10818–10831

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ozgumus OB, Celik-Sevim E, Alpay-Karaoglu S, Sandalli C, Sevim A (2007) Molecular characterization of antibiotic resistant Escherichia coli strains isolated from tap and spring waters in a coastal region in Turkey. J Microbiol 45:379–387

    CAS  PubMed  Google Scholar 

  • Philbert FJ (1991) The Niagara River: a water quality management overview. Environ Monit Assess 17:157–166

    Article  CAS  PubMed  Google Scholar 

  • Pimenta VM, Nepomuceno JC, Pavanin LA (2008) Genotoxicity of water from the Paraguay River near Caceres-MT, Brazil in the Drosophila wing-spot test. Environ Mol Mutagen 49:458–466

    Article  CAS  PubMed  Google Scholar 

  • Raja P, Amarnath AM, Elangovan R, Palanivel M (2008) Evaluation of physical and chemical parameters of river Kaveri, Tiruchirappalli, Tamil Nadu, India. J Environ Biol 29:765–768

    CAS  PubMed  Google Scholar 

  • Ramírez Castillo FY, Avelar González FJ, Garneau P, Márquez Díaz F, Guerrero Barrera AL, Harel J (2013) Presence of multi-drug resistant pathogenic Escherichia coli in the San Pedro river located in the state of Aguascalientes, Mexico. Front Microbiol 4:147. doi:10.3389/ fmicb.2013.00147. eCollection 2013

    Article  PubMed  PubMed Central  Google Scholar 

  • Rashid A (2012). Water pollution: a rising life-threatening problem. Articles and reports, News Central Asia

    Google Scholar 

  • Rather MI, Rashid I, Shahi N, Murtaza KO, Hassan K, Yousuf AR, Romshoo SA, Shah IY (2016) Massive land system changes impact water quality of the Jhelum River in Kashmir Himalaya. Environ Monit Assess 188(3):185. doi:10.1007/s10661-016-5190-x

    Article  CAS  PubMed  Google Scholar 

  • Rosenberg Goldstein RE, Micallef SA, Gibbs SG, George A, Claye E, Sapkota A, Joseph SW, Sapkota AR (2014) Detection of vancomycin-resistant enterococci (VRE) at four U.S. wastewater treatment plants that provide effluent for reuse. Sci Total Environ 466-467:404–411

    Article  CAS  PubMed  Google Scholar 

  • Roser DJ, Ashbolt NHG, Mathew K, Nair J, Ryken-Rapp D, Toze S (2005) Hydrogen sulphide production tests and the detection of groundwater fecal contamination by septic seepage. Water Sci Technol 51:291–300

    Article  CAS  PubMed  Google Scholar 

  • Saha SB, Verma V (2013) In silico analysis of Escherichia coli polyphosphate kinase (PPK) as a novel antimicrobial drug target and its high throughput virtual screening against PubChem library. Bioinformation 9:518–523

    Article  PubMed  PubMed Central  Google Scholar 

  • Sakai H, Kataoka Y, Fukushi K (2013) Quality of source water and drinking water in urban areas of Myanmar. Sci World J 2013:854261. doi:10.1155/2013/854261

    Article  CAS  Google Scholar 

  • Salem IB, Ouardani I, Hassine M, Aouni M (2011) Bacteriological and physicochemical assessment of wastewater in different region of Tunisia: impact on human health. BMC Res Notes 4:144. doi:10.1186/1756-0500-4-144

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sanchez CL, Reynoso FL, Chavez MR, Villa IG, Gavrilov IN, Garcia MP, Velazquez CR, Rodriguez MMM (2012) Assessment of water pollution in different aquatic systems: aquifers, aquatic farms on the Jamapa River, and coastal lagoons of Mexico. J Agr Sci 4:186–193

    Google Scholar 

  • Schjørring S, Krogfelt KA (2011) Assessment of bacterial antibiotic resistance transfer in the gut. Int J Microbiol 2011:312956. doi:10.1155/2011/312956

    Article  PubMed  PubMed Central  Google Scholar 

  • Schwartz T, Kohnen W, Jansen B, Obst U (2003) Detection of antibiotic-resistant bacteria and their resistance genes in wastewater, surface water, and drinking water biofilms. FEMS Microbiol Ecol 43:325–335

    Article  CAS  PubMed  Google Scholar 

  • Sharma A, Bhattacharya A, Bora CR, Shukla V, Parihar P (2012) Diversity of enteropathogens in river Narmada and their environmental and health implications. Microorg Environ Manag Microbes and Environ 1:35–60

    Google Scholar 

  • Sikder MT, Kihara Y, Yasuda M, Yustiawati M, Mihara Y, Tanaka S, Odgerel D, Mijiddorj B, Syawal SM, Hosokawa T, Saito T, Kurasaki M (2013) River water pollution in developed and developing countries: judge and assessment of physicochemical characteristics and selected dissolved metal concentration. CLEAN Soil, Air, Water 41:60–68

    Article  CAS  Google Scholar 

  • Singh PK, Shukla P (2015) Systems biology as an approach for deciphering microbial interactions. Brief Funct Genomics 14(2):166–168. doi:10.1093/bfgp/elu023

    Article  CAS  Google Scholar 

  • Skariyachan S, Mahajanakatti AB, Sharma N, Karanth S, Rao S, Rajeswari N (2012) Structure based virtual screening of novel inhibitors against multidrug resistant superbugs. Bioinformation 8:420–425

    Article  PubMed  PubMed Central  Google Scholar 

  • Skariyachan S, Jayaprakash N, Bharadwaj N, Narayanappa R (2013a) Exploring insights for virulent gene inhibition of multidrug resistant Salmonella typhi, Vibrio cholerae, and Staphylococcus areus by potential phytoligands via in silico screening. J Biomol Struct Dyn 32:1379–1395

    Article  PubMed  CAS  Google Scholar 

  • Skariyachan S, Lokesh P, Rao R, Kumar AU, Vasist K, Narayanappa R (2013b) A pilot study on water pollution and characterization of multidrug resistant superbugs from Byramangala tank, Ramanagara district, Karnataka, India. Environ Monit Assess 185:5483–5495

    Article  CAS  PubMed  Google Scholar 

  • Skariyachan S, Narayan NS, Aggimath TS, Nagaraj S, Reddy MS, Narayanappa R (2014) Molecular modeling on streptolysin-O of multidrug resistant Streptococcus pyogenes and computer aided screening and in vitro assay for novel herbal inhibitors. Curr Comput Aided Drug Des 10(1):59–74

    Article  CAS  PubMed  Google Scholar 

  • Sood A, Singh KD, Pandey P, Sharma S (2008) Assessment of bacterial indicators and physicochemical parameters to investigate pollution status of Gangetic river system of Uttarakhand (India). Ecol Indic 8:709–717

    Article  Google Scholar 

  • Speck-Planche A, Kleandrova VV, Luan F, Cordeiro MN (2012) In silico discovery and virtual screening of multi-target inhibitors for proteins in Mycobacterium tuberculosis. Comb Chem High Throughput Screen 15:666–673

    Article  CAS  PubMed  Google Scholar 

  • Sperber WH, Tatini SR (1975) Interpretation of the tube coagulase test for identification of Staphylococcus aureus. Applied Microbiol 29:502–505

    CAS  Google Scholar 

  • Subrahmanyam G, Shen JP, Liu YR, Archana G, Zhang LM (2016) Effect of long-term industrial waste effluent pollution on soil enzyme activities and bacterial community composition. Environ Monit Assess 188(2):112. doi:10.1007/s10661-016-5099-4

    Article  CAS  PubMed  Google Scholar 

  • Sulkin SE, Willett JC (1940) A triple sugar-ferrous sulfate medium for use in identification of enteric organisms. J Lab Clin Med 25:649–653

    CAS  Google Scholar 

  • Sundar K, Vidya R, Mukherjee A, Chandrasekaran N (2010) High chromium tolerant bacterial strains from Palar River basin: impact of tannery pollution. Res J Environ Earth Sci 2:112–117

    CAS  Google Scholar 

  • Tanwar J, Das S, Fatima Z, Hameed S (2014) Multidrug resistance: an emerging crisis. Interdiscip Perspect Infect Dis 2014:541340. doi:10.1155/2014/541340

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tendall DM, Hellweg S, Pfister S, Huijbregts MA, Gaillard G (2014) Impacts of river water consumption on aquatic biodiversity in life cycle assessment--a proposed method, and a case study for Europe. Environ Sci Technol 48:3236–3244

    Article  CAS  PubMed  Google Scholar 

  • Thevenon F, Adatte T, Wildi W, Poté J (2012) Antibiotic resistant bacteria/genes dissemination in lacustrine sediments highly increased following cultural eutrophication of Lake Geneva (Switzerland). Chemosphere 86:468–476

    Article  CAS  PubMed  Google Scholar 

  • Threlfall EJ, Ward LR, Frost JA, Willshaw GA (2000) The emergence and spread of antibiotic resistance in food-borne bacteria. Int J Food Microbiol 62:1–5

    Article  CAS  PubMed  Google Scholar 

  • Tissera S, Lee SM (2013) Isolation of extended spectrum ß-lactamase (ESBL) producing bacteria from urban surface waters in Malaysia, Malays. J Med Sci 20:14–22

    Google Scholar 

  • Toroglu E, Toroglu S (2009) Microbial pollution of water in Golbasi Lake in Adiyaman, Turkey. J Environ Biol 30:33–38

    PubMed  Google Scholar 

  • Truman AW, Kwun MJ, Cheng J, Yang SH, Suh JW, Hong HJ (2014) Antibiotic resistance mechanisms inform discovery: identification and characterization of a novel amycolatopsis strain producing ristocetin. Antimicrob Agents Chemother 58:5687–5695

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Umamaheswari S, Saravanan AN (2009) Water quality of Cauvery River basin in Trichirappalli, India. Int J Lakes and Rivers 2:1–20

    Google Scholar 

  • van Duin D, Paterson DL (2016) Multidrug-resistant bacteria in the community: trends and lessons learned. Infect Dis Clin N Am 30(2):377–390. doi:10.1016/j.idc.2016.02.004

    Article  Google Scholar 

  • Vanham D, Weingartner R, Rauch W (2011) The Cauvery river basin in southern India: major challenges and possible solutions in the 21st century. Water Sci Technol 64:122–131

    Article  CAS  PubMed  Google Scholar 

  • Varunprasath K, Daniel AN (2010) Comparison studies of three freshwater rivers (Cauvery, Bhavani and Noyyal) in Tamil Nadu, India. Iran J Energy Environ 1:315–320

    Google Scholar 

  • Venkatesha Raju K, Somashekar RK, Prakash KL (2012) Heavy metal status of sediment in river Cauvery, Karnataka. Environ Monit Assess 184:361–373

    Article  CAS  PubMed  Google Scholar 

  • Volberding PA, Deeks SG (2010) Antiretroviral therapy and management of HIV infection. Lancet 376:49–62

    Article  PubMed  Google Scholar 

  • Wallace AJ, Stillman TJ, Atkins A, Jamieson SJ, Bullough PA, Green J, Artymiuk PJ (2000) E. coli hemolysin E (HlyE, ClyA, She A): X-ray crystal structure of the toxin and observation of membrane pores by electron microscopy. Cell 100:265–276

    Article  CAS  PubMed  Google Scholar 

  • Walsh TR, Weeks J, Livermore DM, Toleman MA (2012) Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. Lancet Infect Dis 1:355–362

    Google Scholar 

  • West BM, Liggit P, Clemans DL, Francoeur SN (2011) Antibiotic resistance, gene transfer, and water quality patterns observed in waterways near CAFO farms and wastewater treatment facilities. Water Air Soil Pollut 217:473–489

    Article  CAS  Google Scholar 

  • World Health Organisation (WHO) (2010) Global report on antimalarial drug efficacy and drug resistance: 2000–2010. World Health Organization, Geneva

    Google Scholar 

  • Wogul MD, Okaka CE (2011) Pollution studies on Nigerian rivers: heavy metals in surface water of warri river, Delta State. J Biodivers Environ Sci 1:7–12

    Google Scholar 

  • Wu Q, Zhou H, Tam NF, Tian Y, Tan Y, Zhou S, Li Q, Chen Y, Leung JY (2016) Contamination, toxicity and speciation of heavy metals in an industrialized urban river: implications for the dispersal of heavy metals. Mar Pollut Bull 104(1–2):153–161

    Article  CAS  PubMed  Google Scholar 

  • Xiong W, Li J, Chen Y, Shan B, Wang W, Zhan A (2016) Determinants of community structure of zooplankton in heavily polluted river ecosystems. Sci Rep 6:22043. doi:10.1038/srep22043

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xu ZQ, Flavin MT, Flavin J (2014) Combating multidrug-resistant gram-negative bacterial infections. Expert Opin Investig Drugs 23:163–182

    Article  CAS  PubMed  Google Scholar 

  • Yang TM, Hsu NS, Chiu CC, Wang HJ (2014) Applying the Taguchi method to river water pollution remediation strategy optimization. Int J Environ Res Public Health 11:4108–4124

    Article  PubMed  PubMed Central  Google Scholar 

  • Ye B, Yang L, Li Y, Wang W, Li H (2013) Water sources and their protection from the impact of microbial contamination in rural areas of Beijing, China. Int J Environ Res Public Health 10:879–891

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zeng H, Jinglu WJ (2013) Heavy metal pollution of lakes along the mid-lower reaches of the Yangtze River in China: intensity, sources and spatial patterns. Int J Environ Res Public Health 10:793–807

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang Q, Lambert G, Liao D, Kim H, Robin K, Tung CK, Pourmand N, Austin RH (2011) Acceleration of emergence of bacterial antibiotic resistance in connected microenvironments. Science 333:1764–1767

    Article  CAS  PubMed  Google Scholar 

  • Zhao F, Bai J, Wu J, Liu J, Zhou M (2010) Sequencing and genetic variation of multidrug resistance plasmids in Klebsiella pneumoniae. PLoS One 5(4):e10141. doi:10.1371/journal.pone.0010141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao G, Mu X, Strehmel A, Tian P (2014) Temporal variation of stream flow, sediment load and their relationship in the yellow river basin, china. PLoS One 9:e91048. doi:10.1371/journal.pone. 0091048

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Biotechnology Engineering, Dayananda Sagar Institutions, Bangalore, 560 078, India

    Sinosh Skariyachan

  2. Visvesvaraya Technological University, Belagavi, Karnataka, India

    Sinosh Skariyachan

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  1. Sinosh Skariyachan
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Correspondence to Sinosh Skariyachan .

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  1. Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana, India

    Pratyoosh Shukla

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Skariyachan, S. (2017). Emergence of Multidrug-Resistant Bacteria in Freshwater Ecosystems (River) and Screening of Natural Therapeutics Against the Probable Drug Targets of Drug-Resistant Pathogens by Computational Biology Approaches. In: Shukla, P. (eds) Recent advances in Applied Microbiology . Springer, Singapore. https://doi.org/10.1007/978-981-10-5275-0_5

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