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Calcium Signaling: From Physiology to Diseases pp 61–72Cite as

Voltage-Dependent Calcium Channels: From Physiology to Diseases

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Abstract

“Knowing our genes help knowing our enemy and knowing our therapy”. Ion channels are expressed in every living cell that belongs to a group of membrane proteins that are important for in and out flux of ions of the cells. A mutation in the encoding sequences of calcium channel causes channelopathies. It can be either congenital or acquired. Mutation of ion channels can alter activation, ion selectivity and abnormal gain of function in humans. Acquired forms of channelopathies cause autoimmune disorders or drugs administration. Human Genome Project data revealed that several hundreds of different ion channel genes can be existent. This specific ion channel subunit which is encoded by specific genes assembling with other subunits to form an active membrane pore for selective ions. These disorders are very rare and therefore physicians, patients and scientists are usually not familiar with all aspects of the clinical symptoms. This chapter deals the current knowledge of different calcium channelopathies and also discusses the recent updates in the calcium ion deficit diseases.

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Authors and Affiliations

  1. Department of Biochemistry, Rayalaseema University, Kurnool, AP, India

    Senthilkumar Rajagopal

  2. Center for Developmental Cardiology, Institute of Translational Medicine, Qingdao University, Qingdao, Shandong, China

    Murugavel Ponnusamy

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  1. Senthilkumar Rajagopal
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  2. Murugavel Ponnusamy
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Rajagopal, S., Ponnusamy, M. (2017). Voltage-Dependent Calcium Channels: From Physiology to Diseases. In: Calcium Signaling: From Physiology to Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-10-5160-9_5

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