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NOTCH in Malignant Lymphoma

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Notch Signaling

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Abstract

Next-generation sequencing has provided knowledge about frequent somatic mutations in NOTCH1 and NOTCH2 genes in malignant lymphomas, represented by mature B-cell neoplasms including chronic lymphocytic leukemia. While physiologic roles of NOTCH signaling through NOTCH2 have been amply understood in splenic marginal zone B-cell development, functional significance of NOTCH1 expression in various mature B cells has been elusive, though well-understood in developing thymocytes. The discovery of frequent NOTCH1 mutations in several mature B-cell malignancies, however, reminds us of the importance of NOTCH signaling in mature B cells, by means of reverse genetics.

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  1. Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Shigeru Chiba

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Correspondence to Shigeru Chiba .

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  1. Graduate School of Medicine, Tokushima University , Kuramoto, Tokushima, Japan

    Koji Yasutomo

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Chiba, S. (2017). NOTCH in Malignant Lymphoma. In: Yasutomo, K. (eds) Notch Signaling. Springer, Singapore. https://doi.org/10.1007/978-981-10-4971-2_5

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