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Notch Ligands for Lymphocyte Development

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Notch Signaling

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Abstract

Although Notch signaling is well known to be critical for the specification of cell fate in various developing organs, it has not been fully defined how Notch ligands contribute to triggering through the Notch receptor in those organs, particularly in hematopoietic and lymphoid organs. The timing of the appearance of Notch ligands on the cell surface is thought to be crucial for the triggering between two equivalent progenitors in the lateral inhibition model. By contrast, the features of the Notch-regulating system, in which the Notch ligand functions as an environment factor, can be determined by the cell source of the Notch ligand that is frequently observed in hematopoietic and lymphoid organs. This review focuses on each Notch ligand and its cell source for lymphocyte development; moreover, it emphasizes the characteristics of the bone marrow, thymus, and secondary lymphoid organs based on the Notch system. In particular, the results obtained from the loss-of-function experiments using the defined Cre transgenic mice that are specifically active in the environment are described. In addition, the shared and intrinsic properties, including the structure and function of Notch ligands, are also described. These may be helpful for understanding the physiological significance of Notch ligands and their mediated signaling for the regulation of the lymphoid system.

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  1. Department of Immunology, Tokai University School of Medicine, Isehara, Kanagawa, 259-1193, Japan

    Katsuto Hozumi

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  1. Graduate School of Medicine, Tokushima University , Kuramoto, Tokushima, Japan

    Koji Yasutomo

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Hozumi, K. (2017). Notch Ligands for Lymphocyte Development. In: Yasutomo, K. (eds) Notch Signaling. Springer, Singapore. https://doi.org/10.1007/978-981-10-4971-2_1

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