Abstract
Proteins are macromolecular structures, functionally active in their three-dimensional state, and their entire machinery depends on involvement of number of polypeptides. A perceptive insight of protein folding mechanism is a remarkable task, and various studies in protein structure and function have investigated mechanism of determining protein’s three-dimensional details. Apart from understanding basic energy forces and molecules operational behind protein folding, various computational models have also been designed that outline essential aspects of protein folding mechanism. In the present chapter, we have exercised to bring all aspects of protein folding under one roof with all essential components affecting protein folding, which include major driving forces, mechanisms, folding pathways, thermodynamics, kinetics, effect of chemical reagents, pH, temperature, and computational model to analyze protein folding mechanisms. Reliable prediction of protein folding process allows deducing its appropriate function, and we believe that present chapter will prove a step forward in the respective study.
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Acknowledgment
The author extends her acknowledgment to Science and Engineering Research Board, New Delhi, for providing research support [project file number: DST/SERB YSS/2015/002072] and also extends her thanks to her Ph.D. student Ms. Meenal Rastogi at Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, India.
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Shrivastava, S. (2017). Protein Folding. In: Misra, G. (eds) Introduction to Biomolecular Structure and Biophysics. Springer, Singapore. https://doi.org/10.1007/978-981-10-4968-2_2
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DOI: https://doi.org/10.1007/978-981-10-4968-2_2
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