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Copper(I)-Catalyzed Regio- and Enantioselective Monoborylation of Alkenylsilanes

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Synthesis of Functionalized Organoboron Compounds Through Copper(I) Catalysis

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Abstract

An asymmetric monoborylation of alkenylsilanes catalyzed by a copper(I) complex with chiral bisphosphine ligand BenzP* is reported. The reaction proceeded with excellent regioselectivity and high enantioselectivity to afford the corresponding optically active organoboronate esters with a stereogenic C–B bond containing a vicinal silyl group. The synthetic utility of the product is demonstrated through stepwise transformations to multifunctional optically active compounds in a stereospecific manner.

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Authors and Affiliations

  1. Graduate School of Chemical Sciences and Engineering, Frontier Chemistry Center, Hokkaido University, Sapporo, Hokkaido, Japan

    Koji Kubota

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  1. Koji Kubota
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Correspondence to Koji Kubota .

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Kubota, K. (2017). Copper(I)-Catalyzed Regio- and Enantioselective Monoborylation of Alkenylsilanes. In: Synthesis of Functionalized Organoboron Compounds Through Copper(I) Catalysis. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-10-4935-4_4

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