Skip to main content

Early fMRI Studies of Acupuncture

  • Chapter
  • First Online:
  • 764 Accesses

Abstract

As an ancient therapeutic method, acupuncture has been clinically practiced in Eastern Asia for more than 2000 years. Though acupuncture is used worldwide in recent decades, the underlying biology mechanism is still confusing. Functional magnetic resonance imaging (fMRI), which is a noninvasive, safe, and effective imaging procedure, opens a new window to investigate human brain response to acupuncture stimulation. This chapter will induce the early-stage studies of acupuncture by using fMRI. In early acupuncture fMRI studies, most of the researchers focused on the characteristics of acupuncture like specificity of acupoints and deqi sensation and the comparison of brain responses among different needle parameters, such as the stimulation method, depth of the needle, and duration of the needle. However, there are a number of methodological problems in these studies which may directly result in inconsistent even conflict outcomes. So the reliability of the results is questioned. More suitable experimental design for acupuncture, stricter statistics, and high-quality acupuncture fMRI studies are needed.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Andrews-Hanna JR, Smallwood J, Spreng RN. The default network and self-generated thought: component processes, dynamic control, and clinical relevance. Ann N Y Acad Sci. 2014;1316:29–52.

    Article  PubMed Central  PubMed  Google Scholar 

  • Asghar AU, Green G, Lythgoe MF, et al. Acupuncture needling sensation: the neural correlates of deqi using fMRI. Brain Res. 2010;1315:111–8.

    Article  CAS  PubMed  Google Scholar 

  • Atlas LY, Wager TD. How expectations shape pain. Neurosci Lett. 2012;520(2):140–8.

    Article  CAS  PubMed  Google Scholar 

  • Bai L, Yan H, Li L, et al. Neural specificity of acupuncture stimulation at pericardium 6: evidence from an FMRI study. J Magn Reson Imaging. 2010;31(1):71–7.

    Article  PubMed  Google Scholar 

  • Baxter GD, Bleakley C, McDonough S. Clinical effectiveness of laser acupuncture: a systematic review. J Acupunct Meridian Stud. 2008;1(2):65–82.

    Article  PubMed  Google Scholar 

  • Behbehani MM. Functional characteristics of the midbrain periaqueductal gray. Prog Neurobiol. 1995;46(6):575–605.

    Article  CAS  PubMed  Google Scholar 

  • Beissner F. Functional magnetic resonance imaging studies of acupuncture mechanisms: a critique. Focus Altern Complement Ther. 2011;16(1):3–11.

    Article  Google Scholar 

  • Beissner F, Henke C. Methodological problems in FMRI studies on acupuncture: a critical review with special emphasis on visual and auditory cortex activations. Evid Based Complement Alternat Med. 2011;2011:607637.

    PubMed Central  PubMed  Google Scholar 

  • Beissner F, Deichmann R, Henke C, et al. Acupuncture–deep pain with an autonomic dimension? NeuroImage. 2012;60(1):653–60.

    Article  PubMed  Google Scholar 

  • Bennett CM, Wolford GL, Miller MB. The principled control of false positives in neuroimaging. Soc Cogn Affect Neurosci. 2009;4(4):417–22.

    Article  PubMed Central  PubMed  Google Scholar 

  • Berman BM, Lao L, Langenberg P, et al. Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial. Ann Intern Med. 2004;141(12):901–10.

    Article  PubMed  Google Scholar 

  • Brinkhaus B, Ortiz M, Witt CM, et al. Acupuncture in patients with seasonal allergic rhinitis: a randomized trial. Ann Intern Med. 2013;158:225–34.

    Article  PubMed  Google Scholar 

  • Chen SJ, Meng L, Yan H, et al. Functional organization of complex brain networks modulated by acupuncture at different acupoints belonging to the same anatomic segment. Chin Med J. 2012;125(15):2694–700.

    PubMed  Google Scholar 

  • Chen JE, Glover GH. Functional magnetic resonance imaging methods. Neuropsychol Rev. 2015;25(3):289–313.

    Article  PubMed Central  PubMed  Google Scholar 

  • Cho ZH, Chung SC, Jones JP, et al. New findings of the correlation between acupoints and corresponding brain cortices using functional MRI. Proc Natl Acad Sci USA. 1998;95(5):2670–3.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Cho ZH, Chung SC, Lee HJ, et al. Retraction. New findings of the correlation between acupoints and corresponding brain cortices using functional MRI. Proc Natl Acad Sci USA. 2006;103(27):10527.

    CAS  PubMed  Google Scholar 

  • Cho SY, Jahng GH, Park SU, et al. fMRI study of effect on brain activity according to stimulation method at LI11, ST36: painful pressure and acupuncture stimulation of same acupoints. J Altern Complement Med. 2010;16(4):489–95.

    Article  PubMed  Google Scholar 

  • Claunch JD, Chan ST, Nixon EE, et al. Commonality and specificity of acupuncture action at three acupoints as evidenced by FMRI. Am J Chin Med. 2012;40(4):695–712.

    Article  PubMed Central  PubMed  Google Scholar 

  • Dawidson I, Blom M, Lundeberg T, et al. The influence of acupuncture on salivary flow rates in healthy subjects. J Oral Rehabil. 1997;24(3):204–8.

    Article  CAS  PubMed  Google Scholar 

  • Deng G, Hou BL, Holodny AI, et al. Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: a randomized controlled study. BMC Complement Altern Med. 2008;8:37.

    Article  PubMed Central  PubMed  Google Scholar 

  • Dhond RP, Yeh C, Park K, et al. Acupuncture modulates resting state connectivity in default and sensorimotor brain networks. Pain. 2008;136(3):407–18.

    Article  PubMed Central  PubMed  Google Scholar 

  • Eklund A, Nichols TE, Knutsson H. Cluster failure: why fMRI inferences for spatial extent have inflated false-positive rates. Proc Natl Acad Sci USA. 2016;113(28):7900–5.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Elsenbruch S. How positive and negative expectations shape the experience of visceral pain. Handb Exp Pharmacol. 2014;225:97–119.

    Article  PubMed  Google Scholar 

  • Fang SH, Zhang SZ, Liu H. Study on brain response to acupuncture by functional magnetic resonance imaging—observation on 14 healthy subjects. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006;26(11):965–8.

    PubMed  Google Scholar 

  • Fang J, Jin Z, Wang Y, et al. The salient characteristics of the central effects of acupuncture needling: limbic-paralimbic-neocortical network modulation. Hum Brain Mapp. 2009;30(4):1196–206.

    Article  PubMed  Google Scholar 

  • Fang J, Wang X, Liu H, et al. The limbic-prefrontal network modulated by Electroacupuncture at CV4 and CV12. Evid Based Complement Alternat Med. 2012;2012:515893.

    Google Scholar 

  • Gareus IK, Lacour M, Schulte AC, et al. Is there a BOLD response of the visual cortex on stimulation of the vision-related acupoint GB 37? J Magn Reson Imaging. 2002;15(3):227–32.

    Article  PubMed  Google Scholar 

  • Han JS. Acupuncture analgesia: areas of consensus and controversy. Pain. 2011;152(3 Suppl):S41–8.

    Article  PubMed  Google Scholar 

  • He T, Zhu W, SQ D, et al. Neural mechanisms of acupuncture as revealed by fMRI studies. Auton Neurosci. 2015;190:1–9.

    Article  PubMed  Google Scholar 

  • Huang ST, Chen GY, Lo HM, et al. Increase in the vagal modulation by acupuncture at neiguan point in the healthy subjects. Am J Chin Med. 2005;33:157–64.

    Article  PubMed  Google Scholar 

  • Huang W, Pach D, Napadow V, et al. Characterizing acupuncture stimuli using brain imaging with FMRI—a systematic review and meta-analysis of the literature. PLoS One. 2012;7(4):e32960.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hui KK, Liu J, Makris N, et al. Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects. Hum Brain Mapp. 2000;9(1):13–25.

    Article  CAS  PubMed  Google Scholar 

  • Hui KK, Liu J, Marina O, et al. The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI. NeuroImage. 2005;27(3):479–96.

    Article  PubMed  Google Scholar 

  • Hui KK, Nixon EE, Vangel MG, et al. Characterization of the “deqi” response in acupuncture. BMC Complement Altern Med. 2007;7:33.

    Article  PubMed Central  PubMed  Google Scholar 

  • Hui KK, Marina O, Claunch JD, et al. Acupuncture mobilizes the brain’s default mode and its anti-correlated network in healthy subjects. Brain Res. 2009;1287:84–103.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hui KK, Marina O, Liu J, et al. Acupuncture, the limbic system, and the anticorrelated networks of the brain. Auton Neurosci. 2010a;157(1–2):81–90.

    Article  PubMed Central  PubMed  Google Scholar 

  • Hui KK, Napadow V, Liu J, et al. Monitoring acupuncture effects on human brain by FMRI. J Vis Exp. 2010b;38:1190.

    Google Scholar 

  • Hui KK, Sporko TN, Vangel MG, et al. Perception of Deqi by Chinese and American acupuncturists: a pilot survey. Chin Med. 2011;6(1):2.

    Article  PubMed Central  PubMed  Google Scholar 

  • Jeun SS, Kim JS, Kim BS, et al. Acupuncture stimulation for motor cortex activities: a 3T fMRI study. Am J Chin Med. 2005;33(4):573–8.

    Article  PubMed  Google Scholar 

  • Jiang Y, Wang H, Liu Z, et al. Manipulation of and sustained effects on the human brain induced by different modalities of acupuncture: an fMRI study. PLoS One. 2013;8(6):e66815.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Jiang Y, Liu J, Liu J, et al. Cerebral blood flow-based evidence for mechanisms of low- versus high-frequency transcutaneous electric acupoint stimulation analgesia: a perfusion fMRI study in humans. Neuroscience. 2014;268:180–93.

    Article  CAS  PubMed  Google Scholar 

  • Jin LM, Qin CJ, Lan L, et al. Local anesthesia at ST36 to reveal responding Brain areas to deqi. Evid Based Complement Alternat Med. 2014;2014:987365.

    PubMed Central  PubMed  Google Scholar 

  • Kong J, Ma L, Gollub RL, et al. A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods. J Altern Complement Med. 2002;8(4):411–9.

    Article  PubMed  Google Scholar 

  • Kong J, Gollub R, Huang T, et al. Acupuncture deqi, from qualitative history to quantitative measurement. J Altern Complement Med. 2007a;13(10):1059–70.

    Article  PubMed  Google Scholar 

  • Kong J, Gollub RL, Webb JM, et al. Test-retest study of fMRI signal change evoked by electroacupuncture stimulation. NeuroImage. 2007b;34(3):1171–81.

    Article  PubMed  Google Scholar 

  • Kong J, Kaptchuk TJ, Polich G, et al. An fMRI study on the interaction and dissociation between expectation of pain relief and acupuncture treatment. NeuroImage. 2009a;47(3):1066–76.

    Article  PubMed Central  PubMed  Google Scholar 

  • Kong J, Kaptchuk TJ, Polich G, et al. Expectancy and treatment interactions: a dissociation between acupuncture analgesia and expectancy evoked placebo analgesia. NeuroImage. 2009b;45(3):940–9.

    Article  PubMed  Google Scholar 

  • Kucyi A, Davis KD. The dynamic pain connectome. Trends Neurosci. 2015;38(2):86–95.

    Article  CAS  PubMed  Google Scholar 

  • Leung L. Neurophysiological basis of acupuncture-induced analgesia—an updated review. J Acupunct Meridian Stud. 2012;5(6):261–70.

    Article  PubMed  Google Scholar 

  • Li G, Liu HL, Cheung RT, et al. An fMRI study comparing brain activation between word generation and electrical stimulation of language-implicated acupoints. Hum Brain Mapp. 2003a;18(3):233–8.

    Article  CAS  PubMed  Google Scholar 

  • Li G, Cheung RT, Ma QY, et al. Visual cortical activations on fMRI upon stimulation of the vision-implicated acupoints. Neuroreport. 2003b;14(5):669–73.

    Article  PubMed  Google Scholar 

  • Li K, Shan B, Xu J, et al. Changes in FMRI in the human brain related to different durations of manual acupuncture needling. J Altern Complement Med. 2006;12(7):615–23.

    Article  PubMed  Google Scholar 

  • Li L, Liu H, Li YZ, et al. The human brain response to acupuncture on same-meridian acupoints: evidence from an fMRI study. J Altern Complement Med. 2008;14(6):673–8.

    Article  CAS  PubMed  Google Scholar 

  • Lin JG, Chen WL. Review: acupuncture analgesia in clinical trials. Am J Chin Med. 2009;37(1):1–18.

    Article  CAS  PubMed  Google Scholar 

  • Linnman C, Moulton EA, Barmettler G, et al. Neuroimaging of the periaqueductal gray: state of the field. NeuroImage. 2012;60(1):505–22.

    Article  PubMed  Google Scholar 

  • Liu WC, Feldman SC, Cook DB, et al. fMRI study of acupuncture-induced periaqueductal gray activity in humans. Neuroreport. 2004;15(12):1937–40.

    Article  PubMed  Google Scholar 

  • Liu P, Zhang Y, Zhou G, et al. Partial correlation investigation on the default mode network involved in acupuncture: an fMRI study. Neurosci Lett. 2009;462(3):183–7.

    Article  CAS  PubMed  Google Scholar 

  • Liu H, JY X, Li L, et al. FMRI evidence of acupoints specificity in two adjacent acupoints. Evid Based Complement Alternat Med. 2013;2013:932581.

    PubMed Central  PubMed  Google Scholar 

  • MacPherson H, Green G, Nevado A, et al. Brain imaging of acupuncture: comparing superficial with deep needling. Neurosci Lett. 2008;434(1):144–9.

    Article  CAS  PubMed  Google Scholar 

  • Matthews PM, Jezzard P. Functional magnetic resonance imaging. J Neurol Neurosurg Psychiatry. 2004;75(1):6–12.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Morganstein WM. Acupuncture in the treatment of xerostomia: clinical report. Gen Dent. 2005;53(3):223–7.

    PubMed  Google Scholar 

  • Napadow V, Dhond RP, Purdon P, et al. Correlating acupuncture FMRI in the human brainstem with heart rate variability. Conf Proc IEEE Eng Med Biol Soc. 2005a;5:4496–9.

    PubMed  Google Scholar 

  • Napadow V, Makris N, Liu J, et al. Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI. Hum Brain Mapp. 2005b;24(3):193–205.

    Article  PubMed  Google Scholar 

  • Napadow V, Dhond RP, Kim J, et al. Brain encoding of acupuncture sensation—coupling on-line rating with fMRI. NeuroImage. 2009a;47(3):1055–65.

    Article  PubMed Central  PubMed  Google Scholar 

  • Napadow V, Dhond R, Park K, et al. Time-variant fMRI activity in the brainstem and higher structures in response to acupuncture. NeuroImage. 2009b;47(1):289–301.

    Article  PubMed Central  PubMed  Google Scholar 

  • NIH Consensus Conference. NIH consensus conference. Acupuncture. JAMA. 1998;280(17):1518–24.

    Article  Google Scholar 

  • Poldrack RA. The future of fMRI in cognitive neuroscience. NeuroImage. 2012;62(2):1216–20.

    Article  PubMed  Google Scholar 

  • Quah-Smith I, Williams MA, al LT. Differential brain effects of laser and needle acupuncture at LR8 using functional MRI. Acupunct Med. 2013;31(3):282–9.

    Article  PubMed Central  PubMed  Google Scholar 

  • Raichle ME. The brain's default mode network. Annu Rev Neurosci. 2015;38:433–47.

    Article  CAS  PubMed  Google Scholar 

  • Scheffold BE, Hsieh CL, Litscher G. Neuroimaging and neuromonitoring effects of electro and manual acupuncture on the central nervous system: a literature review and analysis. Evid Based Complement Alternat Med. 2015;2015:641742.

    Google Scholar 

  • Seiji O, Yul-Wan S. Functional magnetic resonance imaging. Scholarpedia. 2007;2(10):3105.

    Article  Google Scholar 

  • Siedentopf CM, Golaszewski SM, Mottaghy FM, et al. Functional magnetic resonance imaging detects activation of the visual association cortex during laser acupuncture of the foot in humans. Neurosci Lett. 2002;327(1):53–6.

    Article  CAS  PubMed  Google Scholar 

  • Sun J, Qin W, Jin L, et al. Impact of global normalization in FMRI acupuncture studies. Evid Based Complement Alternat Med. 2012a;2012:467061.

    PubMed Central  PubMed  Google Scholar 

  • Sun J, Zhu Y, Jin L, et al. Partly separated activations in the spatial distribution between de-qi and sharp pain during acupuncture stimulation: an fMRI-based study. Evid Based Complement Alternat Med. 2012b;2012:934085.

    PubMed Central  PubMed  Google Scholar 

  • Sun J, Zhu Y, Yang Y, et al. What is the de-qi-related pattern of BOLD responses? a review of acupuncture studies in fMRI. Evid Based Complement Alternat Med. 2013;2013:297839.

    PubMed Central  PubMed  Google Scholar 

  • Wang W, Liu L, Zhi X, et al. Study on the regulatory effect of electro-acupuncture on hegu point (LI4) in cerebral response with functional magnetic resonance imaging. Chin J Integr Med. 2007;13(1):10–6.

    Article  PubMed  Google Scholar 

  • Witt C, Brinkhaus B, Jena S, et al. Acupuncture in patients with osteoarthritis of the knee: a randomised trial. Lancet. 2005;366(9480):136–43.

    Article  CAS  PubMed  Google Scholar 

  • WHO. WHO traditional medicine strategy: 2014–2023. Geneva: World Health Organization; 2014.

    Google Scholar 

  • Wu MT, Hsieh JC, Xiong J, et al. Central nervous pathway for acupuncture stimulation: localization of processing with functional MR imaging of the brain—preliminary experience. Radiology. 1999;212(1):133–41.

    Article  CAS  PubMed  Google Scholar 

  • Wu MT, Sheen JM, Chuang KH, et al. Neuronal specificity of acupuncture response: a fMRI study with electroacupuncture. NeuroImage. 2002;16(4):1028–37.

    Article  PubMed  Google Scholar 

  • Xiong J, Liu F, Zhang MM, et al. De-qi, not psychological factors, determines the therapeutic efficacy of acupuncture treatment for primary dysmenorrhea. Chin J Integr Med. 2012;18(1):7–15.

    Article  PubMed  Google Scholar 

  • Xu SB, Huang B, Zhang CY, et al. Effectiveness of strengthened stimulation during acupuncture for the treatment of Bell palsy: a randomized controlled trial. CMAJ. 2013;185(6):473–9.

    Article  PubMed Central  PubMed  Google Scholar 

  • Yassa MA. Functional MRI user’s guide. 2005. http://pni.med.jhu.edu/intranet/fmriguide/.

  • Yeo S, Choe IH, van den Noort M, et al. Consecutive acupuncture stimulations lead to significantly decreased neural responses. J Altern Complement Med. 2010;16(4):481–7.

    Article  PubMed  Google Scholar 

  • Yin CS, Park HJ, Kim SY, et al. Electroencephalogram changes according to the subjective acupuncture sensation. Neurol Res. 2010;32(Suppl 1):31–6.

    Article  CAS  PubMed  Google Scholar 

  • Yoo SS, Teh EK, Blinder RA, et al. Modulation of cerebellar activities by acupuncture stimulation: evidence from fMRI study. NeuroImage. 2004;22(2):932–40.

    Article  PubMed  Google Scholar 

  • Zhang D, Sun JL, Pieper K. Bivariate mixed effects analysis of clustered data with large cluster sizes. Stat Biosci. 2016;8:220–33.

    Article  PubMed  Google Scholar 

  • Zhang WT, Jin Z, Cui GH, et al. Relations between brain network activation and analgesic effect induced by low vs. high frequency electrical acupoint stimulation in different subjects: a functional magnetic resonance imaging study. Brain Res. 2003;982(2):168–78.

    Article  CAS  PubMed  Google Scholar 

  • Zhong ZP, Wu SS, Liu B, et al. Acupuncture at the acupoints of different meridians at the same anatomy level: a study with functional magnetic resonance imaging. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30(6):1363–5, 1372.

    PubMed  Google Scholar 

  • Zyloney CE, Jensen K, Polich G, et al. Imaging the functional connectivity of the periaqueductal gray during genuine and sham electroacupuncture treatment. Mol Pain. 2010;6:80.

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jie Tian .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Cite this chapter

Qin, W., Jin, L., Tian, J. (2018). Early fMRI Studies of Acupuncture. In: Tian, J. (eds) Multi-Modality Neuroimaging Study on Neurobiological Mechanisms of Acupuncture. Springer, Singapore. https://doi.org/10.1007/978-981-10-4914-9_1

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-4914-9_1

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-4913-2

  • Online ISBN: 978-981-10-4914-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics