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Design, Fabrication, and Modification Protocols of Functional Micro-/Nanoimaging Probes

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Advances in Functional Micro-/Nanoimaging Probes

Part of the book series: Engineering Materials ((ENG.MAT.))

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Abstract

The biosafety of micro-/nanoimaging probes is one of the most important elements that should be taken into consideration before their design and fabrication. In order to endow them specificity to lesions and bioavailability in vivo, targeting biomolecules, optimized biodistribution, and acceptable biocompatibility need to be introduced. These prerequisites ensure their behavior in the body and pave the way for their ultimate medical applications in humans, which should be pursued throughout the development of molecular imaging probes.

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References

  1. Hermanson, G.T.: Bioconjugate Techniques, 4th edn. Elsevier Inc. (2013)

    Google Scholar 

  2. Robert, A.F.: Nanomedicine, Volume IIA: Biocompatibility. CRC Press (2003)

    Google Scholar 

  3. Jiang, S., Win, K.Y., Liu, S., Teng, C.P., Zheng, Y., Han, M.Y.: Surface-functionalized nanoparticles for biosensing and imaging-guided therapeutics. Nanoscale 5, 3127–3148 (2013)

    Article  CAS  Google Scholar 

  4. Chiang, C.L.: Controlled growth of gold nanoparticles in aerosol-OT/sorbitan monooleate/isooctane mixed reverse micelles. J. Colloid Interface Sci. 230, 60–66 (2000)

    Article  CAS  Google Scholar 

  5. Spanhel, L., Arpac, E., Schmidt, H.: Semiconductor clusters in the sol-gel process: synthesis and properties of CdS nanocomposites. J. Non-Cryst. Solids 147–148, 657–662 (1992)

    Article  Google Scholar 

  6. Yoffe, S., Leshuk, T., Everett, P., Gu, F.: Superparamagnetic iron oxide nanoparticles (SPIONs): synthesis and surface modification techniques for use with MRI and other biomedical applications. Curr. Pharm. Des. 19, 493–509 (2013)

    Article  CAS  Google Scholar 

  7. Teichmann, A., Heuschkel, S., Jocabi, U., Presse, G., Neubert, R.H.: Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream. Eur. J. Pharm. Biopharm. 67, 699–706 (2007)

    Article  CAS  Google Scholar 

  8. Liu, Z.; Kiessling, F.; Gaetjens, J.: Advanced nanomaterials in multimodal imaging: design, functionalization and biomedical applications. J. Nanomater. 894303 (2010)

    Google Scholar 

  9. Long, N.V., Yang, Y., Teranishi, T., Thi, C.M., Cao, Y., Nogami, M.: Biomedical applications of advanced multifunctional magnetic nanoparticles. J. Nanosci. Nanotechnol. 15, 10091–10107 (2015)

    Article  CAS  Google Scholar 

  10. Geszkemoritz, M., Piotrowska, H., Murias, M.: Thioglycerol-capped Mn-doped ZnS quantum dot bioconjugates as efficient two-photon fluorescent nano-probes for bioimaging. J. Mater. Chem. B 1, 698–706 (2013)

    Article  CAS  Google Scholar 

  11. Zhang, P., Zhao, Z., Li, C., Su, H., Wu, Y., Kwok, R.T.K., Lam, J.W.Y., Gong, P., Cai, L., Tang, B.Z.: Aptamer-decorated self-assembled AIE organic dots for cancer cell targeting and imaging. Anal. Chem. 90, 1063–1067 (2018)

    Article  CAS  Google Scholar 

  12. Su, X., Cheng, K., Jeon, J., Shen, B., Venturin, G.T.: Comparison of two site-specifically 18F-labeled affibodies for PET imaging of EGFR positive tumors. Mol. Pharm. 11, 3947–3956 (2014)

    Article  CAS  Google Scholar 

  13. Yu, G., Liang, J., He, Z., Sun, M.: Quantum dot-mediated detection of γ-aminobutyric acid binding sites on the surface of living pollen protoplasts in Tobacco. Chem. Biol. 13, 723–731 (2006)

    Article  CAS  Google Scholar 

  14. Akerman, M.E., Chan, W.C., Laakkonen, P., Bhatia, S.N., Ruoslahti, E.: Nanocrystal targeting in vivo. Proc. Natl. Acad. Sci. U.S.A. 99, 12617–12621 (2002)

    Article  CAS  Google Scholar 

  15. Wang, Y., Yao, C., Li, C., Ding, L., Liu, J., Dong, P., Fang, H., Lei, Z., Shi, G., Wu, M.: Excess titanium dioxide nanoparticles on the cell surface induce cytotoxicity by hindering ion exchange and disrupting exocytosis processes. Nanoscale 7, 13105–13115 (2015)

    Article  CAS  Google Scholar 

  16. Chatterjee, K., Sarkar, S., Jagajjanani Rao K., Paria, S.: Core/shell nanoparticles in biomedical applications. Adv. Colloid Interface Sci. (2014). https://doi.org/10.1016/j.cis.2013.12.008

  17. Kumar, R., Roy, I., Ohulchanskyy, T.Y., Goswami, L.N., Bonoiu, A.C., Bergey, E.J., Tramposch, K.M., Maitra, A., Prasad, P.N.: Covalently dye-linked, surface-controlled, and bioconjugated organically modified silica nanoparticles as targeted probes for optical imaging. ACS Nano 2, 449–456 (2008)

    Article  CAS  Google Scholar 

  18. Ren, H.B., Wu, B.Y., Chen, J.T., Yan, X.P.: Silica-coated S(2-)-enriched manganese-doped ZnS quantum dots as a photoluminescence probe for imaging intracellular Zn2+ ions. Anal. Chem. 83, 8239–8244 (2011)

    Article  CAS  Google Scholar 

  19. Ma, Q., Nakane, Y., Mori, Y., Hasegawa, M., Yoshioka, Y., Watanabe, T.M., Gonda, K., Ohuchi, N., Jin, T.: Multilayered, core/shell nanoprobes based on magnetic ferric oxide particles and quantum dots for multimodality imaging of breast cancer tumors. Biomaterials 33, 8486–8494 (2012)

    Article  CAS  Google Scholar 

  20. He, K., Tang, M.: Safety of novel liposomal drugs for cancer treatment: Advances and prospects. Chem. Biol. Interact. (2017). https://doi.org/10.1016/j.cbi.2017.09.006

    Article  Google Scholar 

  21. D’souza, A.A., Shegokar, R.: Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications. Expert Opin. Drug Deliv. 13, 1257–1275 (2016)

    Article  CAS  Google Scholar 

  22. Turecek, P.L., Bossard, M.J., Schoetens, F., Ivens, I.A.: PEGylation of biopharmaceuticals: a review of chemistry and nonclinical safety information of approved drugs. J. Pharm. Sci. 105, 460–475 (2016)

    Article  CAS  Google Scholar 

  23. Huang, P., Qian, X., Chen, Y., Yu, L., Lin, H., Wang, L., Zhu, Y., Shi, J.: Metalloporphyrin-encapsulated biodegradable nanosystems for highly efficient magnetic resonance imaging-guided sonodynamic cancer therapy. J. Am. Chem. Soc. 139, 1275–1284 (2017)

    Article  CAS  Google Scholar 

  24. Gabizon, A., Catane, R., Uziely, B., Kaufman, B., Safra, T., Cohen, R., Martin, F., Huang, A., Barenholz, Y.: Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res. 54, 987–992 (1994)

    CAS  Google Scholar 

  25. Gabizon, A., Shmeeda, H., Grenader, T.: Pharmacological basis of pegylated liposomal doxorubicin: impact on cancer therapy. Eur. J. Pharm. Sci. 45, 388–398 (2012)

    Article  CAS  Google Scholar 

  26. Takami, S., Sato, T., Mousavand, T., Adschiri, T.: Hydrothermal synthesis of surface-modified iron oxide nanoparticles. Mater. Lett. 61, 4769–4772 (2007)

    Article  CAS  Google Scholar 

  27. Zheng, Y.H., Yao, C., Feng, B., Wang, Y.: Synthesis and magnetic properties of Fe3O4 nanoparticles. Mater. Res. Bull. 41, 525–529 (2006)

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Wenzhou Medical University, Wenzhou, People’s Republic of China

    Doudou Wang

  2. Institute of Chemistry, Chinese Academy of Sciences, Beijing, People’s Republic of China

    Li Liu

  3. Beijing National Laboratory for Molecular Sciences, Beijing, People’s Republic of China

    Li Liu

  4. Institute for Materials Chemistry and Engineering (IMCE), Kyushu University, Fukuoka, Japan

    Wei Ma

  5. The Second Affiliated Hospital of Zhejiang University, Hangzhou, People’s Republic of China

    Daren Liu

  6. School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

    Qiuming Su

  7. The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China

    Xuemei Gu

  8. Hangzhou Red Cross Hospital, Hangzhou, People’s Republic of China

    Gaoyi Yang

  9. Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, People’s Republic of China

    Zhe Liu

  10. The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China

    Zhe Liu

  11. Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, Zhejiang, People’s Republic of China

    Zhe Liu

  12. Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China

    Zhe Liu

Authors
  1. Doudou Wang
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  2. Li Liu
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  3. Wei Ma
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  4. Daren Liu
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  5. Qiuming Su
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  6. Xuemei Gu
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  7. Gaoyi Yang
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  8. Zhe Liu
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Corresponding author

Correspondence to Li Liu .

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Editors and Affiliations

  1. Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China

    Zhe Liu

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Wang, D. et al. (2018). Design, Fabrication, and Modification Protocols of Functional Micro-/Nanoimaging Probes. In: Liu, Z. (eds) Advances in Functional Micro-/Nanoimaging Probes. Engineering Materials. Springer, Singapore. https://doi.org/10.1007/978-981-10-4804-3_2

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