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Introduction

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Development of a Fully Integrated “Sample-In-Answer-Out” System for Automatic Genetic Analysis

Part of the book series: Springer Theses ((Springer Theses))

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Abstract

The tradition classic approach toward genetic approach is present. Several methods for DNA extraction, amplification and electrophoresis are enumerated. Different kinds of approaches have their own advantages and application occasions. Microfluidic is a newly developed technology that aims at precisely manipulating fluidic of micro-scale. The microfluidic made it possible to integrate tradition genetic analysis process onto one single microchip for automation. Several trials have been made to transplant tradition process onto microfluidic platform, although various weak points restricted them from further industrialization. This chapter will give a brief introduction of the standard three-step process of genetic analysis on each step followed by a detailed expatiation on the development of microfluidic technology. All steps of genetic analysis, extraction, amplification and detection, have all been transplanted on-chip separately, and further researches also reported the integration of partial process. Several integrated systems are also introduced, along with careful evaluations. At the end of chapter, the significance of this study will be stated, and mainlines of following chapters will be addressed.

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  1. National Engineering Research Center for Beijing Biochip Technology, Capitalbio Corporation, Beijing, China

    Bin Zhuang

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Zhuang, B. (2018). Introduction. In: Development of a Fully Integrated “Sample-In-Answer-Out” System for Automatic Genetic Analysis. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-10-4753-4_1

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