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Climate Change Impact on Immune Response in Sheep

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Sheep Production Adapting to Climate Change

Abstract

Sheep are considered one of the most resistant species with respect to climate change and high environmental temperatures. Most studies have focused on the effects of heat stress on the physiological mechanisms of adaptation in dairy cows; few studies have dealt with dairy sheep physiology and, above all, with sheep immunological responses. This chapter will focus on the complex network of mechanisms activated by heat stress as affecting immune responses in sheep. In particular, heat stress will be discussed as an attempt to animals’ homeostasis, thus affecting immune system and inducing activation of inflammatory processes. In particular, it will present a synopsis of the knowledge of the sheep immune system, and the changes induced by heat stress on both innate and adaptive immunity. Recent data suggesting a role of heat stress on perturbation of oxidative balance and the consequent effects on the immune system will be discussed. Finally, a discussion on the effects of heat stress on sheep mammary immunity will be presented.

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References

  • Albenzio M, Caroprese M, Santillo A, Marino R, Taibi L, Sevi A (2004) Effects of somatic cell count and stage of lactation on the plasmin activity and cheese-making properties of ewe milk. J Dairy Sci 87:533–542

    Article  CAS  PubMed  Google Scholar 

  • Albenzio M, Santillo A, Caroprese M, Marino R, Centoducati P, Sevi A (2005) Effect of different ventilation regimes on ewe milk and canestrato pugliese cheese quality in summer. J Dairy Res 72:447–455

    Article  CAS  PubMed  Google Scholar 

  • Albenzio A, Santillo A, Caroprese M, Ruggieri D, Ciliberti M, Sevi A (2012) Immune competence of the mammary gland as affected by somatic cell and pathogenic bacteria in ewes with subclinical mastitis. J Dairy Sci 95:3877–3887

    Article  CAS  PubMed  Google Scholar 

  • Albenzio M, Santillo A, Caroprese M, Ciliberti MG, Marino R, Sevi A (2016) Effect of stage of lactation on the immune competence of goat mammary gland. J Dairy Sci 99:3889–3895

    Article  CAS  PubMed  Google Scholar 

  • Alhidary IA, Abdelrahman MM (2016) Effect of narginin supplementation on productive performance, antioxidant status and immune response in heat-stressed lambs. Small Rumin Res 138:31–36

    Article  Google Scholar 

  • Angelini DJ, Hasday JD, Goldblum SE, Bannerman DD (2005) Tumor necrosis factor-α-mediated pulmonary endothelial barrier dysfunction. Curr Respir Med Rev 1:233–246

    Article  CAS  Google Scholar 

  • Asadullah K, Sterry W, Volk HD (2003) Interleukin-10 therapy-review of a new approach. Pharmacol Rev 55:241–269

    Article  CAS  PubMed  Google Scholar 

  • Asehnoune K, Strassheim D, Mitra S, Kim JY, Abraham E (2004) Involvement of reactive oxygen species in toll like receptor 4-dependent activation of NF-𝜅𝜅B. J Immunol 172:2522–2529

    Article  CAS  PubMed  Google Scholar 

  • Baggiolini M, Clark-Lewis I (1992) Interleukin-8, a chemotactic and inflammatory cytokine. FEBS Lett 307:97–101

    Article  CAS  PubMed  Google Scholar 

  • Bannerman DD (2009) Pathogen-dependent induction of cytokines and other soluble inflammatory mediators during intramammary infection of dairy cows. J Anim Sci 87:10–25

    Article  CAS  PubMed  Google Scholar 

  • Barksby HE, Lea SR, Preshaw PM, Taylor JJ (2007) The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders. Clin Exp Immunol 149:217–225

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Beckman KB, Ames BN (1998) The free radical theory of ageing matures. Physiol Rev 78:547–581

    CAS  PubMed  Google Scholar 

  • Bernabucci U (2012) Impact of hot environment on nutrient requirements. In: Collier RJ, Collier JL (eds) Environmental physiology of livestock. Wiley, Ames, pp 101–128

    Chapter  Google Scholar 

  • Bernabucci U, Lacetera N, Danieli PP, Bani P, Nardone A, Ronchi B (2009) Influence of different periods of exposure to hot environment on rumen function and diet digestibility in sheep. Int J Biometeorol 53:387–395

    Article  CAS  PubMed  Google Scholar 

  • Bertoni G, Bernabucci U, Balestra F (1991) Heat-stress effects on some blood parameters of sheep. In: Ronchi B (ed) Animal husbandry in warm climates, vol 55. Pudoc, Wageningen, pp 98–102

    Google Scholar 

  • Biffl WL, Moore EE, Moore FA, Peterson VM (1996) Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation? Ann Surg 224:647–664

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bradford BJ (2012) Nutrition and immunity. In: Proceedings of the 21st tri-state dairy nutrition conference, Fort Wayne, IN, 24–25 April 2012, pp 5–15

    Google Scholar 

  • Brouckaert P, Fiers W (1996) Tumor necrosis factor and the systemic inflammatory response syndrome. Curr Top Microbiol Immunol 216:167–187

    CAS  PubMed  Google Scholar 

  • Burvenich C, Detilleux J, Paape MJ, Massart-Leën AM (2000) Physiological and genetic factors that influence the cow resistance to mastitis, especially during early lactation. In: Zecconi A (ed) Proceedings of the international symposium on immunology of ruminant mammary gland, Stresa, Italy, pp 9–20

    Google Scholar 

  • Caroprese M, Albenzio M, Annicchiarico G, Sevi A (2006) Changes occurring in immune responsiveness of single- and twin bearing Comisana ewes during the transition period. J Dairy Sci 89:562–568

    Article  CAS  PubMed  Google Scholar 

  • Caroprese M, Albenzio M, Marzano A, Schena L, Annicchiarico G, Sevi A (2010) Relationship between cortisol response to stress and behavior, immune profile, and production performance of dairy ewes. J Dairy Sci 93:2395–2403

    Article  CAS  PubMed  Google Scholar 

  • Caroprese M, Albenzio M, Bruno A, Fedele V, Santillo A, Sevi A (2011) Effect of solar radiation and flaxseed supplementation on milk production and fatty acid profile of lactating ewes under high ambient temperature. J Dairy Sci 94:3856–3867

    Article  CAS  PubMed  Google Scholar 

  • Caroprese M, Albenzio M, Bruno A, Annichiarico G, Marino R, Sevi A (2012) Effects of shade and flaxseed supplementation on welfare of lactating ewes under high ambient temperatures. Small Rumin Res 102:177–185

    Article  Google Scholar 

  • Caroprese M, Ciliberti MG, Annicchiarico G, Albenzio M, Muscio A, Sevi A (2014) Hypothalamic-pituitary-adrenal axis activation and immune regulation in heat-stressed sheep after supplementation with polyunsaturated fatty acids. J Dairy Sci 97:4247–4258

    Article  CAS  PubMed  Google Scholar 

  • Caroprese M, Ciliberti MG, Albenzio M, Annicchiarico G, Sevi A (2015) Dietary polyunsaturated fatty acids from flaxseed affect immune responses of dairy sheep around parturition. Vet Immunol Immunopathol 168:56–60

    Article  CAS  PubMed  Google Scholar 

  • Celi P (2010) The role of oxidative stress in small ruminants’ health and production. Rev Bras Zootec 39:348–363

    Article  Google Scholar 

  • Celi P, Merlo M, Da Dalt L, Stefani A, Barbato O, Gabai G (2011) Relationship between late embryonic mortality and the increase in plasma advanced oxidised protein products (AOPP) in dairy cows. Reprod Fertil Dev 23:527–533

    Article  CAS  PubMed  Google Scholar 

  • Chauahan SS, Celi P, Leury BJ, Clarke IJ, Dunshea FR (2014) Dietary antioxidant at supranutritional doses improve oxidative status and reduce the negative effects of heat stress in sheep. J Anim Sci 92:3364–3374

    Article  Google Scholar 

  • Chung DR, Kasper DL, Panzo RJ, Chitnis T, Grusby MJ, Sayegh MH, Tzianabos AO (2003) CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol 170:1958–1963

    Article  CAS  PubMed  Google Scholar 

  • Ciliberti MG, Albenzio M, Annicchiarico G, Marino R, Santillo A, Sevi A, Caroprese M (2016) Role of different sources of dietary PUFA supplementation on sheep welfare under high ambient temperature. Small Rumin Res 135:32–38

    Article  Google Scholar 

  • Collier RJ, Collier JL, Rhoads RP, Baumgard LH (2008) Invited review: genes involved in the Bovine heat stress response. J Dairy Sci 91:445–454

    Article  CAS  PubMed  Google Scholar 

  • Conti P, Kempuraj D, Kandere K, Di Gioacchino M, Barbacane RC, Castellani ML, Felaco M, Boucher W, Letourneau R, Theoharides TC (2003) IL-10, an inflammatory/inhibitory cytokine, but not always. Immunol Lett 86:123–129

    Article  CAS  PubMed  Google Scholar 

  • Cox SS, Speaker KJ, Beninson LA, Craig WC, Paton MM, Fleshner M (2014) Adrenergic and glucocorticoid modulation of the sterile inflammatory response. Brain Behav Immun 36:183–192

    Article  CAS  PubMed  Google Scholar 

  • D’Rourke O (2009) Nutrition and udder health in dairy cows: a review. Ir Vet J 62:S15–S20

    Article  Google Scholar 

  • De Waal Malefyt R, Figdor C, Huijbens R, Mohan-Peterson S, Bennett B, Culpepper J, Dang W, Zurawski G, de Vries J (1993) Effects of IL-13 on phenotype, cytokine production and cytotoxic function of human monocytes. J Immunol 151:6370–6381

    PubMed  Google Scholar 

  • Doherty M, Kastelein K, Menon S, Andrade S, Coffman R (1993) Modulation of murine macrophage function by IL-13. J Immunol 151:7151–7160

    CAS  PubMed  Google Scholar 

  • Elenkov IJ, Chrousos GP (1999) Stress hormones, Th1/Th2 patterns, pro/anti-inflammatory cytokines and susceptibility to disease. Trends Endocrinol Metab 10:359–368

    Article  CAS  PubMed  Google Scholar 

  • Elhmouzi-Younes J, Boysen P, Pende D, Storset AK, Le Vern Y, Laurent F, Drouet F (2010) Ovine CD16+/CD14− blood lymphocytes present all the major characteristics of natural killer cells. Vet Res 41:04–15

    Article  CAS  Google Scholar 

  • Ellis TN, Beaman BL (2004) Interferon-gamma activation of polymorphonuclear neutrophil function. Immunology 112:2–12

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Entrican G, Wattegedera SR, Griffiths DJ (2015) Exploiting ovine immunology to improve the relevance of biomedical models. Mol Immunol 66:68–77

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Estes DM, Hirano A, Heussler VT, Dobbelaere DAE, Brown WC (1995) Expression and biological activities of bovine interleukin-4: effects of recombinant bovine interleukin-4 on T cell proliferation and B cell differentiation and proliferation in vitro. Cell Immunol 163:268–279

    Article  CAS  PubMed  Google Scholar 

  • Fajardo-Lira CE, Nielsen SS (1998) Effect of psychrotrophic microorganisms on the plasmin system in milk. J Dairy Sci 81:901–908

    Article  CAS  PubMed  Google Scholar 

  • Fleshner M (2013) Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome. Brain Behav Immun 27:1–7

    Article  CAS  PubMed  Google Scholar 

  • Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH (1998) The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol 16:495–521

    Article  CAS  PubMed  Google Scholar 

  • Gloire G, Legrand-Poels S, Piette J (2006) NF-𝜅B activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 72:1493–1505

    Article  CAS  PubMed  Google Scholar 

  • Gouwy M, Struyf S, Proost P, Van Damme J (2005) Synergy in cytokine and chemokine networks amplifies the inflammatory response. Cytokine Growth Factor Rev 16:561–580

    Article  CAS  PubMed  Google Scholar 

  • Guerriero V Jr, Raynes DA (1990) Synthesis of heat stress proteins in lymphocytes from livestock. J Anim Sci 68:2779–2783

    Article  CAS  PubMed  Google Scholar 

  • Gyorffy EJ, Glogauer M, Kennedy L, Reynolds JD (1992) T-cell receptor-γδ association with lymphocyte populations in sheep intestinal mucosa. Immunology 77:25–30

    CAS  PubMed  PubMed Central  Google Scholar 

  • Habeeb AAM, Marai IFM, Kamal TH (1992) Heat stress. In: Phillips C, Piggins D (eds) Farm animals and environment. CAB International, Wallingford, pp 27–47

    Google Scholar 

  • Hall DJ, Brownlee C, Stiles CD (1989) Interleukin-1 is a potent regulator of JE and KC gene expression in quiescent BALB/c fibroblasts. J Cell Physiol 141:154–159

    Article  CAS  PubMed  Google Scholar 

  • Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, Odden AR, Shellito JE, Bagby GJ, Nelson S, Kolls JK (2005) Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med 202:761–769

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Harada A, Sekido N, Akahoshi T, Wada T, Mukaida N, Matsushima K (1994) Essential involvement of interleukin-8 (IL-8) in acute inflammation. J Leukoc Biol 56:559–564

    CAS  PubMed  Google Scholar 

  • Hein WR, Griebel PJ (2003) A road less travelled: large animal models in immunological research. Nat Rev Immunol 3:79–84

    Article  CAS  PubMed  Google Scholar 

  • Hein WR, Mackay CR (1991) Prominence of γδ T cells in the ruminant immune system. Immunol Today 12:30–34

    Article  CAS  PubMed  Google Scholar 

  • Hein WR, Peterhans E (1998) Handbook of vertebrate immunology. Pastoret PP, Griebel P, Bazin H, Govaerts A (eds). Academic, San Diego, p 502

    Google Scholar 

  • Huang W, Na L, Fidel PL, Schwarzenberger P (2004) Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 190:624–631

    Article  CAS  PubMed  Google Scholar 

  • Iwasaki A, Medzhitov R (2004) Toll-like receptor control of the adaptive immune responses. Nat Immunol 5:987–995

    Article  CAS  PubMed  Google Scholar 

  • Jabrane-Ferrat N, Siewiera J (2014) The up side of decidual natural killer cells: new developments in immunology of pregnancy. Immunology 141:490–497

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kehrli E Jr, Lee AH, Ackermann MR (2000) Acute phase response of the bovine mammary gland to Escherichia coli. In: Zecconi A (ed) Proceedings of the international symposium on immunology of ruminant mammary gland, Stresa, Italy, pp 21–29

    Google Scholar 

  • Keller ET, Wanagat J, Ershler WB (1996) Molecular and cellular biology of interleukin-6 and its receptor. Front Biosci 1:d340–d357

    Article  CAS  PubMed  Google Scholar 

  • King IL, Mohrs M (2009) IL-4–producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J Exp Med 206:1001–1007

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kobayashi Y (2008) The role of chemokines in neutrophil biology. Front Biosci 13:2400–2407

    Article  CAS  PubMed  Google Scholar 

  • Lacetera N, Bernabucci U, Scalia D, Ronchi B, Kuzminsky G, Nardone A (2005) Lymphocyte functions in dairy cows in hot environment. Int J Biometeorol 50:105–110

    Article  PubMed  Google Scholar 

  • Langrish CL, McKenzie BS, Wilson NJ, de Waal Malefyt R, Kastelein RA, Cua DJ (2004) IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev 202:96–105

    Article  CAS  PubMed  Google Scholar 

  • Lund BT, Evans CW, Davis WC, McConnell I, Bujdoso R (1993) Expression of T19 (WC1) molecules by ovine lymphocytes. Vet Immunol Immunopathol 39:145–153

    Article  CAS  PubMed  Google Scholar 

  • Makay CR, Beya M-F, Matzinger P (1989) γ/δ T cells express a unique surface molecule appearing late during thymic development. Eur J Immunol 19:1477–1483

    Article  Google Scholar 

  • Marai IFM, El-Darawany AA, Fadiel A, Abdel-Hafez MAM (2007) Physiological traits as affected by heat stress in sheep – a review. Small Rumin Res 71:1–12

    Article  Google Scholar 

  • Martin CA, Kurkowski DL, Valentino AM, Schwarz FS (2009) Increased intracellular, cell surface, and secreted inducible heat shock protein 70 responses are triggered during the monocyte to dendritic cell (DC) transition by cytokines independently of heat stress and infection and may positively regulate DC growth. J Immunol 183:388–399

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Matsukawa A, Hogaboam CM, Lukacs NW, Kunkel SL (2000) Chemokines and innate immunity. Rev Immunogenet 2:339–358

    CAS  PubMed  Google Scholar 

  • Matteri RL, Carroll JA, Dyer CJ (2000) Neuroendocrine responses to stress. In: Sejrsen K, Hvelplund T, Nielsen MO (eds) The biology of animal stress. CABI-Publishing, Wallingford, pp 43–76

    Google Scholar 

  • McKenzie GJ, Emson CL, Bell SE, Anderson S, Fallon P, Zurawski G, Murray R, McKenzie ANJ (1998) Impaired development of Th2 cells in IL-13-deficient mice. Immunity 9:423–432

    Article  CAS  PubMed  Google Scholar 

  • Miller JK, Brzezinskaslebodzinska E, Madsen FC (1993) Oxidative stress, antioxidants, and animal function. J Dairy Sci 76:2812–2823

    Article  CAS  PubMed  Google Scholar 

  • Miossec P, Kolls JK (2012) Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov 11:763–776

    Article  CAS  PubMed  Google Scholar 

  • Mocellin S, Marincola F, Rossi CR, Nitti D, Lise M (2004) The multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzle. Cytokine Growth Factor Rev 15:61–76

    Article  CAS  PubMed  Google Scholar 

  • Moore KW, de Waal MR, Coffman RL, O’Garra A (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19:683–765

    Article  CAS  PubMed  Google Scholar 

  • Mujahid A, Yoshiki Y, Akiba Y, Toyomizu M (2005) Superoxide radical production in chicken skeletal muscle induced by acute heat stress. Poult Sci 84:307–314

    Article  CAS  PubMed  Google Scholar 

  • Mukaida N (2003) Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am J Phys Lung Cell Mol Phys 284:L566–L577

    CAS  Google Scholar 

  • Murzenok PP, Netukova NI, Zhytkevitch TI (1997) Ultrastructure and functional state of rabbit lymphoid cells after repeated exposure to lipopolysaccharide and external heating. Arch Immunol Ther Exp 45:301–305

    CAS  Google Scholar 

  • Nalubamba KS, Gossner AG, Dalziel RG, Hopkins J (2007) Differential expression of pattern recognition receptors in sheep tissues and leukocyte subsets. Vet Immunol Immunopathol 118:252–262

    Article  CAS  PubMed  Google Scholar 

  • Noack M, Miossec P (2014) Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev 13:668–677

    Article  CAS  PubMed  Google Scholar 

  • Oosterveld FG, Rasker JJ (1994) Effect of local heat and cold treatment on surface and articular temperature of arthritic knees. Arthritis Rheum 37:1578–1582

    Article  CAS  PubMed  Google Scholar 

  • Oviedo-Boyso J, Valdez-Alarcón JJ, Cajero-Juárez M, OchoaZarzosa A, López-Meza JE, Bravo-Patiño A, Baizabal-Aguirre VM (2007) Innate immune response of bovine mammary gland to pathogenic bacteria responsible for mastitis. J Infect 54:399–409

    Article  PubMed  Google Scholar 

  • Park HG, Han SI, Oh SY, Kang HS (2005) Cellular responses to mild heat stress. Cell Mol Life Sci 62:10–23

    Article  CAS  PubMed  Google Scholar 

  • Punnonen J, Aversa G, Cocks BG, McKenzie ANJ, Menon S, Zurawski G, De Waal Malefyt R, De Vries JE (1993) Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci 90:3730–3734

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rhoads RP, Baumgard LH, Suagee JK, Sanders SR (2013) Nutritional interventions to alleviate the negative consequences of heat stress. Adv Nutr 4:267–276

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rock KL, Latz E, Ontiveros F, Kono H (2010) The sterile inflammatory response. Annu Rev Immunol 28:321–342

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Romero RD, Pardo AM, Montaldo HH, Rodríguez AD, Romero JHC (2013) Differences in body temperature, cell viability, and HSP-70 concentrations between Pelibuey and Suffolk sheep under heat stress. Trop Anim Health Prod 45:1691–1696

    Article  PubMed  Google Scholar 

  • Rosen O, Pedersen BK, Øritsland TR, Bahr R, Kjeldsen-Kragh J (2001) Leukocyte counts and lymphocyte responsiveness associated with repeated bouts of strenuous endurance exercise. J Appl Physiol 91:425–434

    Google Scholar 

  • Saker KE, Fike JH, Veit H, Ward DL (2004) Brown seaweed-(Tasco™) treated conserved forage enhances antioxidant status and immune function in heat-stressed wether lambs. J Anim Physiol Anim Nutr 88:122–130

    Article  CAS  Google Scholar 

  • Salces-Ortiz J, Gonzáez C, Moreno-Sánchez N, Calvo JH, Pérez-Guzmán M, Serrano MM (2013) Ovine HSP90AA1 expression rate is affected by several SNPs at the promoter under both basal and heat stress conditions. PLoS One 8:e66641

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schoenborn JR, Wilson CB (2007) Regulation of interferon-γ during innate and adaptive immune responses. Adv Immunol 96:41–101

    Article  CAS  PubMed  Google Scholar 

  • Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004) Interferon-γ: an overview of signals, mechanisms and functions. J Leukoc Biol 75:163–189

    Article  CAS  PubMed  Google Scholar 

  • Sejian V, Maurya VP, Naqvi SMK (2010) Adaptive capability as indicated by endocrine and biochemical responses of Malpura ewes subjected to combined stresses (thermal and nutritional) in a semi-arid tropical environment. Int J Biometeorol 54:653–661

    Article  PubMed  Google Scholar 

  • Sevi A, Massa S, Annicchiarico G, Dell’Aquila S, Muscio A (1999) Effect of stocking density on ewes milk yield, udder health and micro-environment. J Dairy Res 66:489–499

    Article  CAS  PubMed  Google Scholar 

  • Sevi A, Annicchiarico G, Albenzio M, Taibi L, Muscio A, Dell’Aquila S (2001) Effects of solar radiation and feeding time on behavior, immune response and production of lactating ewes under high ambient temperature. J Dairy Sci 84:629–640

    Article  CAS  PubMed  Google Scholar 

  • Sevi A, Albenzio M, Annicchiarico G, Caroprese M, Marino R, Taibi L (2002) Effects of ventilation regimen on the welfare and performance of lactating ewes in summer. J Anim Sci 80:2349–2361

    Article  CAS  PubMed  Google Scholar 

  • Sevi A, Taibi L, Albenzio M, Annicchiarico G, Marino R, Caroprese M (2003) Influence of ventilation regimen on micro-environment and on ewe welfare and milk yield in summer. Ital J Anim Sci 2:197–212

    Article  Google Scholar 

  • Sevi A, Albenzio M, Annicchiarico G, Caroprese M, Marino R, Santillo A (2006) Effects of dietary protein level on ewe milk yield and nitrogen utilization, and on air quality under different ventilation rates. J Dairy Sci 73:197–206

    CAS  Google Scholar 

  • Sgorlon S, Colitti M, Asquini E, Ferrarini A, Pallavicini A, Stefanon B (2012) Administration of botanicals with the diet regulates gene expression in peripheral blood cells of Sarda sheep during ACTH challenge. Domest Anim Endocrinol 43:213–226

    Article  CAS  PubMed  Google Scholar 

  • Silanikove N (2000) Effects of heat stress on the welfare of extensively managed domestic ruminants. Livest Prod Sci 67:1–18

    Article  Google Scholar 

  • Silanikove N, Shapiro F, Shinder D (2009) Acute heat stress brings down milk secretion in dairy cows by up-regulating the activity of the milk-borne negative feedback regulatory system. BCM Physiol 9:13

    Google Scholar 

  • Sordillo LM (2013) Selenium-dependent regulation of oxidative stress and immunity in periparturient dairy cattle. Vet Med Int 2:1–8

    Article  CAS  Google Scholar 

  • Sordillo LM, Raphael W (2013) Significance of metabolic stress, lipid mobilization, and inflammation on transition cow disorders. Vet Clin N Am Food Anim Pract 29:267–278

    Article  Google Scholar 

  • Spears JW, Weiss WP (2008) Role of antioxidants and trace elements in health and immunity of transition dairy cows. Vet J 176:70–76

    Article  CAS  PubMed  Google Scholar 

  • Szczęsna M, Kirsz K, Kmiotek M, Zieba DA (2015) Seasonal fluctuation in the steady-state mRNA levels of suppressor of cytokine signaling-3 (SOCS-3) in the mammary gland of lactating and non-lactating ewes. Small Rumin Res 124:101–104

    Article  Google Scholar 

  • Todini I (2007) Thyroid hormones in small ruminants: effects of the endogenous, environmental and nutritional factors. Animal 1:997–1008

    Article  CAS  PubMed  Google Scholar 

  • Trinchieri G (1998) Proinflammatory and immunoregulatory functions of interleukin-12. Int Rev Immunol 16:365–396

    Article  CAS  PubMed  Google Scholar 

  • Trinchieri G (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3:133–146

    Article  CAS  PubMed  Google Scholar 

  • van der Poll T, van Deventer SJ (1998) The role of interleukin 6 in endotoxin-induced inflammatory responses. Prog Clin Biol Res 397:365–377

    PubMed  Google Scholar 

  • Vijayan MM, Raptis S, Sathiyaa R (2003) Cortisol treatment affects glucocorticoid receptor and glucocorticoid-responsive genes in the liver of rainbow trout. Gen Comp Endocrinol 132:256–263

    Article  CAS  PubMed  Google Scholar 

  • Wadekar SA, Li DP, Periyasamy S, Sanchez ER (2001) Inhibition of heat shock transcription factor by GR. Mol Endocrinol 15:1396–1410

    Article  CAS  PubMed  Google Scholar 

  • Wahl SM, Hunt DA, Wong HL, Dougherty S, McCartney-Francis N, Wahl LM, Ellingsworth L, Schmidt JA, Hall G, Roberts AB, Sporn MB (1988) Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation. J Immunol 140:3026–3032

    CAS  PubMed  Google Scholar 

  • Wattegedera S, Sills K, Howard CJ, Hope JC, McInnes CJ, Entrican G (2004) Variability in cytokine production and cell proliferation by mitogen-activate ovine peripheral blood mononuclear cells: modulation by interleukin (IL)-10 and IL-12. Vet Immunol Immunopathol 102:67–76

    Article  CAS  PubMed  Google Scholar 

  • Wattegedera S, Rocchi M, Sales J, Howard CJ, Hope JC, Entrican G (2008) Antigen-specific peripheral immune responses are unaltered during normal pregnancy in sheep. J Reprod Immunol 77:171–178

    Article  CAS  PubMed  Google Scholar 

  • Wattegedera S, Corripio-Miyar Y, Pang Y, Frew D, McNeilly TN, McInnes C, Hope J, Glass E, Entrican G (2015) Evaluation of methods and development of reagents for the detection of native bovine and ovine IL-17 A production. Book of abstract of 5th European Veterinary Immunology Workshop (EVIW), p 38

    Google Scholar 

  • Webster JJ, Tonelli L, Sternberg EM (2002) Neuroendocrine regulation of immunity. Annu Rev Immunol 20:125–163

    Article  CAS  PubMed  Google Scholar 

  • Zurawski G, de Vries J (1994) Interleukin-13, and interleukin-4 like cytokine that acts on monocytes and B-cells but not on T-cells. Immunol Today 15:19–26

    Article  CAS  PubMed  Google Scholar 

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  1. Department of the Sciences of Agriculture, Food and Environment (SAFE), University of Foggia, Via Napoli, 25, 71122, Foggia, Italy

    Mariangela Caroprese, Maria Giovanna Ciliberti, Marzia Albenzio & Agostino Sevi

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  1. Mariangela Caroprese
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  2. Maria Giovanna Ciliberti
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  3. Marzia Albenzio
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  4. Agostino Sevi
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Corresponding author

Correspondence to Mariangela Caroprese .

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Editors and Affiliations

  1. Animal Physiology Division, ICAR-National Institute of Animal Nutrition and Physiology, Bangalore, Karnataka, India

    Veerasamy Sejian

  2. ICAR-National Institute of Animal Nutrition and Physiology, Bangalore, Karnataka, India

    Raghavendra Bhatta

  3. School of Agriculture and Food Sciences, The University of Queensland, Gatton, Queensland, Australia

    John Gaughan

  4. Bioenergetics and Environmental Sciences Division, ICAR-National Institute of Animal Nutrition and Physiology, Bangalore, Karnataka, India

    Pradeep Kumar Malik

  5. Division of Physiology of Biochemistry, ICAR-Central Sheep and Wool Research Institute, Avikanagar, Malpura, Rajasthan, India

    S.M.K Naqvi

  6. Carbon Management and Sequestration Centre, School of Environment and Natural Resources, The Ohio State University, Columbus, Ohio, USA

    Rattan Lal

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© 2017 Springer Nature Singapore Pte Ltd.

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Caroprese, M., Ciliberti, M.G., Albenzio, M., Sevi, A. (2017). Climate Change Impact on Immune Response in Sheep. In: Sejian, V., Bhatta, R., Gaughan, J., Malik, P., Naqvi, S., Lal, R. (eds) Sheep Production Adapting to Climate Change. Springer, Singapore. https://doi.org/10.1007/978-981-10-4714-5_4

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