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Nanomaterials in Antioxidant Research

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Oxidative Stress: Diagnostic Methods and Applications in Medical Science

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Abstract

Oxidative stress is proposed as leading event in the deterioration of health and basic biological processes. Ever since the Harman’s theory of aging was proposed based on the ill effects of oxidative in the body, the pace of oxidative stress research became rapid. The antioxidants were proposed as putative therapeutic and prophylactic agents for the prevention of oxidative damage and its aftermath. Despite the escalating research publications in the domain of oxidative stress and antioxidant therapy, apparent clinical transitions are fairly low. Perhaps, this should not be looked as question on the studies which were performed on the antioxidants, rather our poor understanding of cross talk of antioxidants and oxidants in the cells and its downstream effects. It seems that decision of considering antioxidants as miracle drugs for aging and similar condition was too early. There is lot more to be explored in this domain, and as we move deeper, we realize that oxidative stress and antioxidant interplay is one of the most complicated biological events that has several fold more complexity than basic cellular processes and metabolism. The scientific questions such as how much antioxidant dose is optimal and which antioxidant is most suitable can only be answered in a context-specific manner. The several anomalies and unfruitful clinical translations of antioxidants have led to the continuation and intensification of antioxidant research. With the advent of a new domain of science named nanotechnology, few exciting possibilities have emerged in the antioxidant researches which are likely to answer some of the issues of conventional antioxidants. This chapter is aimed to discuss the emerging trends in nano-antioxidants with a special focus on much-studied antioxidant nanoceria.

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Authors and Affiliations

  1. Peptide and Proteomics Division, Defence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Development Organization, Lucknow Road, Timarpur, Delhi, 110054, India

    Aditya Arya & Anamika Gangwar

  2. Division of Infectious Diseases, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

    Narendra Kumar Sharma

Authors
  1. Aditya Arya
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  2. Anamika Gangwar
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  3. Narendra Kumar Sharma
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Corresponding author

Correspondence to Narendra Kumar Sharma .

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Editors and Affiliations

  1. Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, India

    Pawan Kumar Maurya

  2. Department of Biosciences and Bioengineering, Indian Institute of Technology, Guwahati , Guwahati, Assam, India

    Pranjal Chandra

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Arya, A., Gangwar, A., Sharma, N.K. (2017). Nanomaterials in Antioxidant Research. In: Maurya, P., Chandra, P. (eds) Oxidative Stress: Diagnostic Methods and Applications in Medical Science. Springer, Singapore. https://doi.org/10.1007/978-981-10-4711-4_3

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