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Nano-based Delivery System for Nutraceuticals: The Potential Future

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Advances in Animal Biotechnology and its Applications

Abstract

Nutraceuticals are food products that have health and medical benefits, hence promoting their use in prevention and treatment of diseases. Recently, nutraceuticals have come to limelight because of current lifestyle trends which lead to improper nutrition thereby creating a need for food supplements. Due to improper systemic delivery and poor oral bioavailability, potential use of nutraceuticals is limited. Most of the nutraceuticals show difficulty in adsorption through intestinal epithelium due to the presence of bilayer lipid membrane. Other factors such as low solubility or stability of nutraceuticals under harsh gastric conditions limit their beneficial use in health industry. Nanoencapsulation of nutraceuticals can improve their bioavailability thereby increasing health benefits. Recently there has been extensive research on encapsulation of nutraceuticals into biodegradable nanocarriers so as to increase their absorption and hence the therapeutic potential. Various materials have been used for formation of protective shell of encapsulates. The material should be food-grade and biodegradable and must be able to protect the internal phase from its surroundings. Of all the materials of choice, most frequently used are polysaccharides. Proteins and lipids are also promising candidates for appropriate encapsulation. The potential of nanotechnology to overcome the various limitations with the nutraceuticals based on the recent developments in this area are being reported.

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References

  • Altındal DC, Gümüşderelioglu M (2015) Melatonin releasing PLGA micro/nanoparticles and their effect on osteosarcoma cells. J Microencapsul 33(1):1–12

    Google Scholar 

  • Amin AR, Kucuk O, Khuri FR, Shin DM (2009) Perspectives for cancer prevention with natural compounds. J Clin Oncol 27:2712–2725

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Antônio E, Khalil NM, Mainardes RM (2016) Bovine serum albumin nanoparticles containing quercetin: characterization and antioxidant activity. J Nanosci Nanotechnol 16:1346–1353

    Article  CAS  PubMed  Google Scholar 

  • Augustin MA, Hemar Y (2009) Nano- and micro-structured assemblies for encapsulation of food ingredients. Chem Soc Rev 38(4):902–912

    Article  CAS  PubMed  Google Scholar 

  • Augustin MA, Sanguansri L (2012) Challenges in developing delivery systems for food additives, nutraceuticals, and dietary supplements. In: Garti N, McClements DJ (eds) Encapsulation technologies and delivery systems for food ingredients and nutraceuticals. Woodhead Publishing, Cambridge, UK, pp 19–48

    Chapter  Google Scholar 

  • Augustin MA, Abeywardena MY, Patten G, Head R et al (2011) Effects of microencapsulation on the gastrointestinal transit and tissue distribution of a bioactive mixture of fish oil, tributyrin and resveratrol. J Funct Foods 3:25–37

    Article  CAS  Google Scholar 

  • Bell LN (2001) Stability testing of nutraceuticals and functional foods. In: Wildman REC (ed) Handbook of nutraceuticals and functional foods. CRC Press, New York, pp 501–516

    Google Scholar 

  • Bernela M, Ahuja M, Thakur R (2016a) Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles. Carbohydr Polym 143:18–24

    Article  CAS  PubMed  Google Scholar 

  • Bernela M, Ahuja M, Thakur R (2016b) Enhancement of anti-inflammatory activity of glycyrrhizic acid by encapsulation in chitosan-katira gum nanoparticles. Eur J Pharm Biopharm 105:141–147

    Article  CAS  PubMed  Google Scholar 

  • Blazevic F, Milekic T, Romic MD, Juretic M et al (2016) Nanoparticle-mediated interplay of chitosan and melatonin for improved wound epithelialisation. Carbohydr Polym 146:445–454

    Article  CAS  PubMed  Google Scholar 

  • Bourbon AI, Cerqueira MA, Vicente AA (2016) Encapsulation and controlled release of bioactive compounds in lactoferrin-glycomacropeptide nanohydrogels: curcumin and caffeine as model compounds. J Food Eng 180:110–119

    Article  CAS  Google Scholar 

  • Bouwmeester H, Dekkers S, Noordam MY, Hagens WI et al (1998) Nutraceuticals: poised for a healthy slice of the healthcare market? Nat Biotechnol 16:728–731

    Article  Google Scholar 

  • Chaiyasan W, Srinivas SP, Tiyaboonchai W (2016) Development and characterization of topical ophthalmic formulations containing lutein-loaded mucoadhesive nanoparticles. Int J Pharm Pharm Sci 8(3):261–266

    CAS  Google Scholar 

  • Das S, Chaudhury A (2010) Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS Pharm Sci Tech 12:62–76

    Article  CAS  Google Scholar 

  • Fakhoury IH, Saad WS, Gali-Muhtasib HU, Schneider-Stock R (2014) Thymoquinone nanoparticle formulation and in vitro efficacy in: materials for drug & gene delivery & cancer nanotech. Nanotech (2014) 2:367–370

    CAS  Google Scholar 

  • Fakoor Yazdan Abad M, Rajabzadeh G, Taghvaei Ganjali S, Tavakoli R (2016) Preparing allicin nanocapsules and determining the factors controlling their particle size through artificial intelligence. Int J Food Eng 12(3):257–264

    Article  CAS  Google Scholar 

  • Fathi M, Varshosaz J, Mohebbi M, Shahidi F (2013) Hesperetin-loaded solid lipid nanoparticles and nanostructure lipid carriers for food fortification: preparation, characterization, and modeling. Food Bioprocess Technol 6:1464–1475

    Article  CAS  Google Scholar 

  • Ferrari M (2005) Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 5:161–171

    Article  CAS  PubMed  Google Scholar 

  • Frede K, Henze A, Khalil M, Baldermann S, Schweigert FJ, Rawel H (2014) Stability and cellular uptake of lutein-loaded emulsions. J Funct Foods 8:118–127

    Article  CAS  Google Scholar 

  • Grabley S, Thiericke R (1999) Bioactive agents from natural sources: trends in discovery and application. Adv Biochem Eng Biotechnol 64:101–154

    PubMed  CAS  Google Scholar 

  • Guan X, Gao M, Xu H, Zhang C et al (2016) Quercetin-loaded poly (lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for the targeted treatment of liver cancer. Drug Deliv 23(9):3307–3318

    Article  CAS  PubMed  Google Scholar 

  • Hong DY, Lee J-S, Lee HG (2015) Chitosan/poly-rmgamma-glutamic acid nanoparticles improve the solubility of lutein. Int J Biol Macromol 85:9–15

    Article  CAS  PubMed  Google Scholar 

  • Huang Q, Yu H, Ru Q (2013) Bioavailability and delivery of nutraceuticals using nanotechnology. J Food Sci 75:50–57

    Article  CAS  Google Scholar 

  • Javeri I (2016) Application of “nano” nutraceuticals in medicine. In: Nutraceuticals: efficacy, safety and toxicity. Elsevier, Amsterdam, pp 189–192

    Chapter  Google Scholar 

  • Joung HJ, Choi M-J, Kim JT, Park SH, Park HJ, Shin GH (2016) Development of food-grade curcumin nanoemulsion and its potential application to food beverage system: antioxidant property and in vitro digestion. J Food Sci 81:745–753

    Article  CAS  Google Scholar 

  • Jourghanian P, Ghaffari S, Ardjmand M, Haghighat S, Mohammadnejad M (2016) Sustained release curcumin loaded solid lipid nanoparticles. Advan Pharma Bulletin 6:17–21

    Article  CAS  Google Scholar 

  • Kalra EK (2003) Nutraceutical – definition and introduction. AAPS Pharm Sci 5:27–28

    Article  Google Scholar 

  • Kim JH, Park EY, Ha HK, Jo CM et al (2016) Resveratrol-loaded nanoparticles induce antioxidant activity against oxidative stress. Asian-Aust J Anim Sci 29(2):288–298

    Article  CAS  Google Scholar 

  • Kosaraju SL (2005) Colon targeted delivery systems: review of polysaccharides for encapsulation and delivery. Crit Rev Food Sci Nutr 45(4):251–258

    Article  CAS  PubMed  Google Scholar 

  • Krausz AE, Adler BL, Cabral V, Navati M et al (2015) Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomed: Nanotechnol Biol Med 11(1):195–206

    Article  CAS  Google Scholar 

  • Langer R (1990) New methods of drug delivery. Science 249:1527–1533

    Article  CAS  PubMed  Google Scholar 

  • Lasic DD (1998) Novel applications of liposomes. Trends Biotechnol 16:307–321

    Article  CAS  PubMed  Google Scholar 

  • Lasic DD, Martin FJ, Gabizon A, Huang SK, Papahadjopoulos D (1991) Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times. Biochim Biophys Acta 1070:187–192

    Article  CAS  PubMed  Google Scholar 

  • Leach AR, Gillet VJ, Lewis RA, Taylor R (2010) Three-dimensional pharmacophore methods in drug discovery. J Med Chem 53:539–558

    Article  CAS  PubMed  Google Scholar 

  • Li Y, Xiao H, McClements DJ (2012) Encapsulation and delivery of crystalline hydrophobic nutraceuticals using nanoemulsions: factors affecting polymethoxyflavone solubility. Food Biophys 7(4):341–353

    Article  PubMed  PubMed Central  Google Scholar 

  • Li C, Zhang X, Huang X, Wang X, Liao G, Chen Z (2013) Preparation and characterization of flexible nanoliposomes loaded with daptomycin, a novel antibiotic for topical skin therapy. Int J Nanomedicine 8:1285–1292

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Livney YD (2008) Complexes and conjugates of biopolymers for delivery of bioactive ingredients via food. In: Delivery and controlled release of bioactives in foods and nutraceuticals, Woodhead Publishing series in Food Science, Technology and Nutrition. Woodhead, Cambridge, pp 234–242

    Chapter  Google Scholar 

  • Manea A-M, Vasile BS, Meghea A (2014) Antioxidant and antimicrobial activities of green tea extract loaded into nanostructured lipid carriers. C R Chim 17:331–341

    Article  CAS  Google Scholar 

  • McClements DJ, Decker EA, Park Y, Weiss J (2009) Structural design principles for delivery of bioactive components in nutraceuticals and functional foods. Crit Rev Food Sci Nutr 49(6):577–606

    Article  CAS  PubMed  Google Scholar 

  • McClements DJ (2012a) Advances in fabrication of emulsions with enhanced functionality using structural design principles. Curr Opin Colloid Interface Sci 17(5):235–245

    Article  CAS  Google Scholar 

  • McClements DJ (2012b) Requirements for food ingredient and nutraceutical delivery systems. In: Encapsulation technologies and delivery systems for food ingredients and nutraceuticals. Woodhead Publishing, Cambridge, pp 3–18

    Chapter  Google Scholar 

  • McClements DJ (2012c) Nanoemulsions versus microemulsions: clarification of differences, similarities and terminology. Soft Matter 8(6):1719–1729

    Article  CAS  Google Scholar 

  • Molinski TF (1993) Developments in marine natural products, receptor-specific bioactive compounds. J Nat Prod 56:1–8

    Article  CAS  PubMed  Google Scholar 

  • Momekova D, Rangelov S, Yanev S, Nikolova E et al (2007) Long-circulating, pH-sensitive liposomes sterically stabilized by copolymers bearing short blocks of lipid-mimetic units. Eur J Pharm Sci 32:308–317

    Article  CAS  PubMed  Google Scholar 

  • Mozafari MR, Mortazavi SM (2005) Nanoliposomes: from fundamentals to recent developments. Trafford, Pub Ltd, Oxford. UK

    Google Scholar 

  • Mozafari MR, Flanagan J, Matia-Merino L et al (2006) Recent trends in the lipid-based nanoencapsulation of antioxidants and their role in foods. J Sci Food Agric 86(13):2038–2045

    Article  CAS  Google Scholar 

  • Mozafari MR, Pardakhty A, Azarmi S, Jazayeri JA et al (2009) Role of nanocarrier systems in cancer nanotherapy. J Liposome Res 19:310–321

    Article  CAS  PubMed  Google Scholar 

  • Munin A, Edwards-Levy F (2011) Encapsulation of natural polyphenolic compounds: a review. Pharmaceutics 3:793–829

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Neves AR, Martins S, Segundo MA, Reis S (2016) Nanoscale delivery of resveratrol towards enhancement of supplements and nutraceuticals. Forum Nutr 8:131

    Google Scholar 

  • Pandey M, Verma RK, Saraf SA (2010) Nutraceuticals: new era of medicine and health. Asian J Pharm Clin Res 3:11–15

    Google Scholar 

  • Paul SD, Dewangan D (2016) Nanotechnology and nutraceuticals. Int J Nanomater Nanotechnol Nanomed 2(1):9–12

    Google Scholar 

  • Pradhan N, Singh S, Ojha N, Shrivastava A et al (2015) Facets of nanotechnology as seen in food processing, packaging, and preservation industry. Bio Med Res Int 2015:365672

    Google Scholar 

  • Puglia C, Offerta A, Tirendi GG, Tarico MS et al (2016) Design of solid lipid nanoparticles for caffeine topical administration. Drug Deliv 23(1):36–40

    Article  CAS  PubMed  Google Scholar 

  • Qi LF, Xu ZR, Jiang X, Hu C, Zou X (2004) Preparation and antibacterial activity of chitosan nanoparticles. Carbohydr Res 339(16):2693–2700

    Article  CAS  PubMed  Google Scholar 

  • Qian C, Decker EA, Xiao H, McClements DJ (2012) Nanoemulsion delivery systems: influence of carrier oil on beta-carotene bioaccessibility. Food Chem 135:1440–1447

    Article  CAS  PubMed  Google Scholar 

  • Rani R, Dilbaghi N, Dhingra D, Kumar S (2015) Optimization and evaluation of bioactive drug-loaded polymeric nanoparticles for drug delivery. Int J Biol Macromol 78:173–179

    Article  CAS  PubMed  Google Scholar 

  • Rapaka RS, Coates PM (2006) Dietary supplements and related products: a brief summary. Life Sci 78:2026–2032

    Article  CAS  PubMed  Google Scholar 

  • Ravanfar R, Tamaddon AM, Niakousari M, Moein MR (2016) Preservation of anthocyanins in solid lipid nanoparticles: optimization of a microemulsion dilution method using the Plackett–Burman and Box–Behnken designs. Food Chem 199(15):573–580

    Article  CAS  PubMed  Google Scholar 

  • Rein MJ, Renouf M, Cruz-Hernandez C, Actis-Goretta L, Thakkar SK, da Silva MP (2013) Bioavailability of bioactive food compounds: a challenging journey to bioefficacy. Br J Clin Pharmacol 75:588–602

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Renard D, Robert P, Lavenant L, Melcion D et al (2002) Biopolymeric colloidal carriers for encapsulation or controlled release applications. Int J Pharm 242(1–2):163–166

    Article  CAS  PubMed  Google Scholar 

  • Riehemann K, Schneider SW, Luger TA, Godin B (2009) Nanomedicine-challenge and perspectives. Angew Chem Int Ed Eng 48:872–897

    Article  CAS  Google Scholar 

  • Scampicchio M, Ballabio D, Arecchi A, Cosio SM, Mannino S (2008) Amperometric electronic tongue for food analysis. Microchim Acta 163:11–21

    Article  CAS  Google Scholar 

  • Severino P, Andreani T, Macedo AS, Fangueiro JF et al (2011) Current state-of-art and new trends on lipid nanoparticles (SLN and NLC) for oral drug delivery. J Drug Deliv 12:1–10

    Google Scholar 

  • Shoji Y, Nakashima H (2004) Nutraceutics and delivery systems. J Drug Target 12:385–391

    Article  CAS  PubMed  Google Scholar 

  • Singhal NK, Agarwal S, Bhatnagar P, Tiwari MN et al (2015) Mechanism of nanotization-mediated improvement in the efficacy of caffeine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism. J Biomed Nanotechnol 11(12):2211–2222

    Article  CAS  PubMed  Google Scholar 

  • Sinha VR, Kumria R (2001) Polysaccharides in colon-specific drug delivery. Int J Pharm 224:19–38

    Article  CAS  PubMed  Google Scholar 

  • Sivakumar M, Tang SY, Tan KW (2014) Cavitation technology – a greener processing technique for the generation of pharmaceutical nanoemulsions. Ultrason Sonochem 21:2069–2083

    Article  CAS  PubMed  Google Scholar 

  • Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma MJ (2005) Nanoemulsions. Curr Opin Colloid Interface Sci 10(3–4):102–110

    Article  CAS  Google Scholar 

  • Sondi I, Salopek-Sondi B (2004) Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gramnegative bacteria. J Colloid Interface Sci 275(1):177–182

    Article  CAS  PubMed  Google Scholar 

  • Sun Y, Xia Z, Zheng J, Qiu P, Zhang L, McClements DJ, Xiao H (2015) Nanoemulsion-based delivery systems for nutraceuticals: influence of carrier oil type on bioavailability of pterostilbene. J Funct Foods 13:61–70

    Article  CAS  Google Scholar 

  • Tang S, Gao D, Zhao T, Zhou J, Zhao X (2013) An evaluation of the anti-tumor efficacy of oleanolic acid-loaded PEGylated liposomes. Nanotechnology 24:235102

    Article  CAS  PubMed  Google Scholar 

  • Taylor TM, Davidson PM, Bruce BD, Weiss J (2005) Liposomal nanocapsules in food science and agriculture. Crit Rev Food Sci Nutr 45(7–8):587–605

    Article  CAS  PubMed  Google Scholar 

  • Tiede K, Boxall ABA, Tear SP, Lewis J, David H, Hassellov M (2008) Detection and characterization of engineered nanoparticles in food and the environment. Food Addit Contam Part A-Chem Anal Control Expo Risk Assess 25(7):795–821

    Article  CAS  PubMed  Google Scholar 

  • Ting YW, Jiang Y, Ho CT, Huang QR (2014) Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals. J Funct Foods 7:112–128

    Article  CAS  Google Scholar 

  • Trottier G, Boström PJ, Lawrentschuk N, Fleshner NE (2010) Nutraceuticals and prostate cancer prevention. A Curr Rev Nat Rev Urol 7:21–30

    Article  CAS  Google Scholar 

  • Vidal SL, Rojas C, Padin RB, Rivera MP, Haensgen A, Gonzalez M, Rodriguez-Llamazares S (2016) Synthesis and characterization of polyhydroxybutyrate-cohydroxyvalerate nanoparticles for encapsulation of quercetin. J Bioact Compat Polym 31(5):1–14

    Google Scholar 

  • Vijayakumar MR, Kumari L, Patel KK, Vuddanda PR et al (2016) Intravenous administration of trans-resveratrol-loaded TPGS-coated solid lipid nanoparticles for prolonged systemic circulation, passive brain targeting and improved in vitro cytotoxicity against C6 glioma cell lines. RSC Adv 6:50336–50348

    Article  CAS  Google Scholar 

  • Wagner V, Dullaart A, Bock AK, Zweck A (2006) The emerging nanomedicine landscape. Nat Biotechnol 24:1211–1217

    Article  CAS  PubMed  Google Scholar 

  • Weber S, Zimmer A, Pardeike J (2014) Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for pulmonary application: a review of the state of the art. Eur J Pharma Biopharm 86:7–22

    Article  CAS  Google Scholar 

  • Yu H, Huang Q (2013) Bioavailability and delivery of nutraceuticals and functional foods using nanotechnology. In: Di B, Bagchi M, Moriyama H, Shahidi F (eds) Bio-nanotechnology: a revolution in food, biomedical and health sciences, 1st edn. Blackwell Publishing Ltd., Oxford. https://doi.org/10.1002/9781118451915. ch35

    Chapter  Google Scholar 

  • Zheng J, Li Y, Song M, Fang X et al (2014) Improving intracellular uptake of 5-demethyltangeretin by food grade nanoemulsions. Food Res Int 62:98–103

    Article  CAS  Google Scholar 

  • Zhu Y, Peng W, Zhang J, Wang M et al (2014) Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: preparation, in vitro and in vivo evaluation. J Funct Foods 8:358–366

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Bio & Nanotechnology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India

    Manju Bernela, Munish Ahuja & Rajesh Thakur

  2. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Pawan Kaur

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  1. Manju Bernela
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  2. Pawan Kaur
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  3. Munish Ahuja
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  4. Rajesh Thakur
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Editors and Affiliations

  1. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Suresh Kumar Gahlawat

  2. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Joginder Singh Duhan

  3. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Raj Kumar Salar

  4. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Priyanka Siwach

  5. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Suresh Kumar

  6. Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, India

    Pawan Kaur

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Bernela, M., Kaur, P., Ahuja, M., Thakur, R. (2018). Nano-based Delivery System for Nutraceuticals: The Potential Future. In: Gahlawat, S., Duhan, J., Salar, R., Siwach, P., Kumar, S., Kaur, P. (eds) Advances in Animal Biotechnology and its Applications. Springer, Singapore. https://doi.org/10.1007/978-981-10-4702-2_7

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