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Mitochondrial-Associated Membranes in Parkinson’s Disease

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 997))

Abstract

Parkinson’s disease (PD) is a common neurodegenerative disorder, with ageing being a major risk factor. Accordingly, estimates predict an increasing number of PD patients due to our expanding life span. Consequently, developing a true disease-modifying therapy is necessary. In this regard, monogenic PD offers a suitable means for determining pathogenesis. Among monogenic forms of PD, mitochondrial dysfunction may be a major cause and is also likely to be involved in sporadic PD. Thus, mitochondrial impairment may be a common pathway. Recently, mitochondria-associated membranes (MAM) were identified as dynamic sites between mitochondria and endoplasmic reticulum. Indeed, the gene product of α-synuclein is a major component of MAM, with other gene products also involved. This review focuses on the possibility of using MAM as novel therapeutic targets.

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Authors and Affiliations

  1. Department of Neurology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8421, Japan

    Nobutaka Hattori, Taku Arano, Taku Hatano, Akio Mori & Yuzuru Imai

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  1. Nobutaka Hattori
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  2. Taku Arano
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  3. Taku Hatano
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  4. Akio Mori
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  5. Yuzuru Imai
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Correspondence to Nobutaka Hattori .

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Editors and Affiliations

  1. School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan

    Mitsuo Tagaya

  2. Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada

    Thomas Simmen

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Hattori, N., Arano, T., Hatano, T., Mori, A., Imai, Y. (2017). Mitochondrial-Associated Membranes in Parkinson’s Disease. In: Tagaya, M., Simmen, T. (eds) Organelle Contact Sites. Advances in Experimental Medicine and Biology, vol 997. Springer, Singapore. https://doi.org/10.1007/978-981-10-4567-7_12

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